• BRENDA home

• Basic Ligand Information
• • Molecular Structure
  • Sum Formula
  • BRENDA Name
  • Synonyms
  • InChIKey
  • Pathways
• Roles as Enzyme Ligand
• • In Vivo Substrate
  • In Vivo Product
  • Substrate
  • Product
  • Cofactor
  • Activator
  • Inhibitor
  • Metals and Ions
  • 3D Structure (PDB)
• Enzyme Kinetic Parameters
• • k_cat Value (Turnover Number)
  • K_M Value
  • K_i Value
  • IC₅₀ Value
• References & Links
• • References
  • Links

print visible entries

print all entries

Ligand (R)-4-phosphopantoate

Basic Ligand Information

Molecular Structure

Show all BRENDA pathways known for (R)-4-phosphopantoate

close all tables

open all tables

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Natural Substrate (3 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

727436

-

6.3.2.26

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

727436

-

6.3.2.36

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

746403, 722842

-

Substrate in Enzyme-catalyzed Reactions (3 results)

top print hide

Show Substrate (3 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.33

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

727436

-

6.3.2.26

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

727436

-

6.3.2.36

ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)-4'-phosphopantothenate

746403, 722842

-

Product in Enzyme-catalyzed Reactions (2 results)

top print hide

Show Product (2 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

2.7.1.169

ATP + (R)-pantoate = ADP + (R)-phosphopantoate

-

-

2.7.1.169

UTP + (R)-pantoate = UDP + (R)-phosphopantoate

-

-

2.7.1.169

2 entries

Enzyme Kinetic Parameters

K_M Value (1 result)

top print hide

Show KM Value (1 entry)

EC NUMBER

KM VALUE [MM]

KM VALUE MAXIMUM [MM]

COMMENTARY

LITERATURE

6.3.2.26

1.16

-

pH 6.5, 85°C

727436

References & Links

Literature References (3)

top print hide

Show Reference (3 entries)

BRENDA REFERENCE ID

PUBMED ID

TITLE

YEAR

AUTHORS

JOURNAL

VOLUME

PAGES

722842

23200110

Identification of pantoate kinase and phosphopantothenate synthetase from Methanospirillum hungatei

2013

Katoh, H.; Tamaki, H.; Tokutake, Y.; Hanada, S.; Chohnan, S.

J. Biosci. Bioeng.

115

372-376

727436

22940806

A detailed biochemical characterization of phosphopantothenate synthetase, a novel enzyme involved in coenzyme A biosynthesis in the Archaea

2012

Ishibashi, T.; Tomita, H.; Yokooji, Y.; Morikita, T.; Watanabe, B.; Hiratake, J.; Kishimoto, A.; Kita, A.; Miki, K.; Imanaka, T.; Atomi, H.

Extremophiles

16

819-828

746403

24638914

Crystal structure of phosphopantothenate synthetase from Thermococcus kodakarensis

2014

Kishimoto, A.; Kita, A.; Ishibashi, T.; Tomita, H.; Yokooji, Y.; Imanaka, T.; Atomi, H.; Miki, K.

Proteins

82

1924-1936

Links to other databases for (R)-4-phosphopantoate

top print hide

Show Links (1 entry)

ChEBI

PubChem

-