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1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
-
-
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
?
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)glutathione + HCl
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
?
-
-
-
-
?
4-nitrophenethyl bromide + glutathione
?
-
-
-
-
?
allyl isothiocyanate + glutathione
?
-
-
-
-
?
benzyl isothiocyanate + glutathione
?
-
-
-
-
?
cumene hydroperoxide + glutathione
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
-
-
-
-
?
glutathione + 1-bromo-4-nitrobenzene
bromide + 4-nitrophenyl-glutathione
-
recombinant catalytically active monoclonal antibody fragment ScFv2F3
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
-
-
-
-
?
glutathione + 1-iodobutane
iodide + butyl-glutathione
-
-
-
-
?
glutathione + 1-iodohexane
iodide + hexyl-glutathione
-
-
-
-
?
glutathione + 1-iodomethane
iodide + methylglutathione
-
-
-
-
?
glutathione + 4-hydroxydecenal
?
-
-
-
-
?
glutathione + 4-hydroxynonenal
?
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
-
-
-
-
?
glutathione + cryptophycin 52
?
-
conjugation with the R-stereoisomer
-
-
?
glutathione + cryptophycin 53
?
-
conjugation with the S-stereoisomer
-
-
?
glutathione + cumene hydroperoxide
?
-
isozyme MI
-
-
?
hydrogen peroxide + glutathione
?
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
-
-
-
-
?
propyl isothiocyanate + glutathione
?
-
-
-
-
?
RX + glutathione
HX + R-S-glutathione
styrene oxide + glutathione
?
-
-
-
-
?
tertiary butyl hydroperoxide + glutathione
?
-
-
-
-
?
additional information
?
-
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
-
enzyme MIII
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
-
recombinant catalytically active monoclonal antibody fragment ScFv2F3
-
-
?
RX + glutathione
HX + R-S-glutathione
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
-
?
RX + glutathione
HX + R-S-glutathione
-
participates in detoxification
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
specificity
-
-
?
additional information
?
-
-
GST isozymes play independent roles that characterize multiple processes within vomeronasal organ chemosensitivity
-
-
?
additional information
?
-
-
infection of skeletal muscle with Trichinella spiralis affects the Km of the enzyme due to alterations of the enzyme's quarternary structure, overview
-
-
?
additional information
?
-
-
mu- and pi-class GST activities
-
-
?
additional information
?
-
-
the selenomethionine-labeled antibody fragment ScFv2F3 is catalytically inactive
-
-
?
additional information
?
-
-
the murine isozyme GST T1-1 is 80fold more active than the human isozyme GST T1-1
-
-
?
additional information
?
-
-
substrate specificity, overview. A major structural determinant of substrate recognition is the H-site, which binds the electrophile in proximity to the nucleophilic sulfur of the second substrate glutathione. H-site residue 234 has a key role in governing the activity and substrate selectivity profile of GST T1-1
-
-
?
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0.6 - 0.8
1,3-Bis-(2-chloroethyl)-1-nitrosourea
2.284
1-chloro-2,4-dinitrobenzene
-
pH 6.5, 25°C, recombinant catalytically active monoclonal antibody fragment ScFv2F3
0.56
1-Iodobutane
-
pH 8.0, 30°C, recombinant wild-type enzyme
0.059
1-iodohexane
-
pH 8.0, 30°C, recombinant wild-type enzyme
0.91
1-iodomethane
-
pH 8.0, 30°C, recombinant wild-type enzyme
0.455
glutathione
-
pH 6.5, 25°C, recombinant catalytically active monoclonal antibody fragment ScFv2F3
additional information
additional information
-
0.6
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
pH 7.4, 37°C, recombinant mutant F2:1215
0.8
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
pH 7.4, 37°C, recombinant wild-type isozyme GST-T1-1
additional information
additional information
-
-
-
additional information
additional information
-
biphasic kinetics of enzyme from healthy and muscle with experimental trichinellosis in presence or absence of albendazole, overview
-
additional information
additional information
-
kinetics, single-enzyme Michaelis-Menten model
-
additional information
additional information
-
steady-state kinetics of the recombinant catalytically active monoclonal antibody fragment ScFv2F3, dependence on substrate concentrations, overview
-
additional information
additional information
-
kinetic analysis of wild-type and mutant enzymes, overview
-
additional information
additional information
-
steady-state kinetics of recombinant His6-tagged isozyme GST T1-1, substrate 1,3-bis-(2-chloroethyl)-1-nitrosourea
-
additional information
additional information
the native enzyme and the C169A mutant exhibit MichaelisMenten kinetics, but all other thiol to alanine mutants exhibit sigmoidal kinetics to varying degrees, ping-pong kinetics of mutant C169A, overview
-
additional information
additional information
-
the native enzyme and the C169A mutant exhibit MichaelisMenten kinetics, but all other thiol to alanine mutants exhibit sigmoidal kinetics to varying degrees, ping-pong kinetics of mutant C169A, overview
-
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2.3 - 3.6
1,3-Bis-(2-chloroethyl)-1-nitrosourea
2286
1-chloro-2,4-dinitrobenzene
-
pH 6.5, 25°C, recombinant catalytically active monoclonal antibody fragment ScFv2F3
0.137
1-Iodobutane
-
pH 8.0, 30°C, recombinant wild-type enzyme
3.17
1-iodohexane
-
pH 8.0, 30°C, recombinant wild-type enzyme
238
1-iodomethane
-
pH 8.0, 30°C, recombinant wild-type enzyme
2286
glutathione
-
pH 6.5, 25°C, recombinant catalytically active monoclonal antibody fragment ScFv2F3
2.3
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
pH 7.4, 37°C, recombinant wild-type isozyme GST-T1-1
3.6
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
pH 7.4, 37°C, recombinant mutant F2:1215
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Warholm, M.; Jensson, H.; Tahir, M.K.; Mannervik, B.
Purification and characterization of three distinct glutathione transferases from mouse liver
Biochemistry
25
4119-4125
1986
Mus musculus
brenda
Jakoby, W.B.
Glutathione transferases: an overview
Methods Enzymol.
113
495-499
1985
Ovis aries, Homo sapiens, Mus musculus, Rattus norvegicus
brenda
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Multiple forms of mouse glutathione S-transferases
Biochem. Soc. Trans.
12
30-33
1984
Mus musculus
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Kitteringham, N.R.; Powell, H.; Jenkins, R.E.; Hamlett, J.; Lovatt, C.; Elsby, R.; Henderson, C.J.; Wolf, C.R.; Pennington, S.R.; Park, B.K.
Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver
Proteomics
3
191-207
2003
Mus musculus
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Green, N.; Weech, M.; Walters, E.
Localization and characterization of glutathione-S-transferase isozymes alpha, mu, and pi within the mouse vomeronasal organ
Neurosci. Lett.
375
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2005
Mus musculus
brenda
Gyamfi, M.A.; Wan, Y.J.
The effect of ethanol, ethanol metabolizing enzyme inhibitors, and Vitamin E on regulating glutathione, glutathione S-transferase, and S-adenosylmethionine in mouse primary hepatocyte
Hepatol. Res.
35
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2006
Mus musculus
brenda
Zhang, K.; Zang, T.Z.; Yang, W.; Sun, Y.; Mu, Y.; Liu, J.Q.; Shen, J.C.; Luo, G.M.
Single chain antibody displays glutathione S-transferase activity
J. Biol. Chem.
281
12516-12520
2006
Mus musculus
brenda
Wojtkowiak, A.; Boczo?, K.; Wandurska-Nowak, E.; Derda, M.
Evaluation of effects of albendazole on the kinetics of cytosolic glutathione transferase in skeletal muscles during experimental trichinellosis in mice
Parasitol. Res.
100
647-651
2007
Mus musculus, Mus musculus BALB/c
brenda
Cannady, E.A.; Chien, C.; Jones, T.M.; Borel, A.G.
In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S-transferase: species differences and stereoselectivity
Xenobiotica
36
659-670
2006
Canis lupus familiaris, Macaca fascicularis, Homo sapiens, Mus musculus, Rattus norvegicus, Mus musculus CD1
brenda
Torres-Rivera, A.; Landa, A.
Glutathione transferases from parasites: a biochemical view
Acta Trop.
105
99-112
2008
Homo sapiens, Echinococcus granulosus (O16058), Rattus norvegicus (P04905), Schistosoma mansoni (P15964), Mus musculus (P24472), Schistosoma japonicum (P26624), Onchocerca volvulus (P46427), Ascaris suum (P46436), Fasciola hepatica (P56598), Sus scrofa (P80031), Clonorchis sinensis (Q1L2C7), Taenia solium (Q3ZJN3), Ancylostoma caninum (Q6J1M5), Plasmodium yoelii (Q7REH6), Wuchereria bancrofti (Q86LL8), Plasmodium falciparum (Q8MU52)
brenda
Larsson, A.K.; Shokeer, A.; Mannervik, B.
Molecular evolution of theta-class glutathione transferase for enhanced activity with the anticancer drug 1,3-bis-(2-chloroethyl)-1-nitrosourea and other alkylating agents
Arch. Biochem. Biophys.
497
28-34
2010
Homo sapiens, Mus musculus
brenda
Shokeer, A.; Mannervik, B.
Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1
Biochim. Biophys. Acta
1800
466-473
2010
Mus musculus, Rattus norvegicus, Homo sapiens (P30711), Homo sapiens
brenda
McManus, G.; Costa, M.; Canals, A.; Coll, M.; Mantle, T.J.
Site-directed mutagenesis of mouse glutathione transferase P1-1 unlocks masked cooperativity, introduces a novel mechanism for ping pong kinetic behaviour, and provides further structural evidence for participation of a water molecule in proton abstract
FEBS J.
278
273-281
2011
Mus musculus (P19157), Mus musculus
brenda
Dobritzsch, D.; Grancharov, K.; Hermsen, C.; Krauss, G.J.; Schaumloeffel, D.
Inhibitory effect of metals on animal and plant glutathione transferases
J. Trace Elem. Med. Biol.
57
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2020
Armoracia rusticana, Astacus astacus, Brassica juncea, Oryctolagus cuniculus, Lemna minor, Meleagris gallopavo, Mus musculus, Oncorhynchus mykiss, Oreochromis mossambicus, Oryza sativa, Pacifastacus leniusculus, Picea abies, Pleuronectes platessa, Populus sp., Pelophylax ridibundus, Rattus norvegicus, Typha latifolia, Rhabdosargus sarba, Chelon saliens, Protaetia brevitarsis, Alburnus tarichi, Salvelinus alpinus, Siganus canaliculatus, Laeonereis acuta
brenda