Ligand glutathione

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Basic Ligand Information

Molecular Structure

C₁₀H₁₇N₃O₆S

glutathione

RWSXRVCMGQZWBV-WDSKDSINSA-N

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Synonyms:

5-L-glutamyl-Cys-Gly, gamma-Glu-Cys-Gly, gamma-Glu-L-Cys-Gly, gamma-glutathione, gamma-L-Glu-L-Cys-Gly, gamma-L-glutamyl-L-cysteinyl-glycine, glutathione-SH, glutathione/cytoplasm, glutathione/vacuole, glutathione[side 1], glutathione[side 2], GS-, GSH, L-gamma-Glu-L-Cys-Gly, L-glutathione, reduced glutathione, reduced L-glutathione, S-glutathione[side 1]

Related pathways

BRENDA

arachidonic acid metabolism, cysteine metabolism, formaldehyde oxidation, glutathione metabolism, methylglyoxal degradation

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KEGG

ABC transporters, Bile secretion, Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Cysteine and methionine metabolism

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MetaCyc

4-hydroxy-2-nonenal detoxification, 5-oxo-L-proline metabolism, alliin metabolism, alpha-linolenate metabolites biosynthesis, arachidonate metabolites biosynthesis, arsenate detoxification I, arsenate detoxification III, arsenic detoxification (mammals), arsenic detoxification (plants), arsenic detoxification (yeast), arsenite methylation (bacterial), ascorbate glutathione cycle, ascorbate recycling (cytosolic), assimilatory sulfate reduction II, camalexin biosynthesis, di-homo-gamma-linolenate metabolites biosynthesis, docosahexaenoate metabolites biosynthesis, drosopterin and aurodrosopterin biosynthesis, formaldehyde oxidation II (glutathione-dependent), gamma-glutamyl cycle, gamma-hexachlorocyclohexane degradation, gliotoxin biosynthesis, glucosinolate biosynthesis from dihomomethionine, glucosinolate biosynthesis from hexahomomethionine, glucosinolate biosynthesis from homomethionine, glucosinolate biosynthesis from pentahomomethionine, glucosinolate biosynthesis from phenylalanine, glucosinolate biosynthesis from tetrahomomethionine, glucosinolate biosynthesis from trihomomethionine, glucosinolate biosynthesis from tryptophan, glucosinolate biosynthesis from tyrosine, glutathione biosynthesis, glutathione degradation (DUG pathway), glutathione-glutaredoxin redox reactions, glutathione-mediated detoxification I, glutathione-mediated detoxification II, glutathione-peroxide redox reactions, glutathionylspermidine biosynthesis, guaiacylglycerol-beta-guaiacyl ether degradation, homophytochelatin biosynthesis, hypoglycin biosynthesis, icosapentaenoate metabolites biosynthesis, indole glucosinolate activation (herbivore attack), indole glucosinolate activation (intact plant cell), isoprene degradation, L-cysteine biosynthesis VII (from S-sulfo-L-cysteine), leukotriene biosynthesis, linoleate metabolites biosynthesis, lipoxin biosynthesis, methiin metabolism, methylglyoxal degradation I, methylglyoxal degradation VIII, pentachlorophenol degradation, peptido-conjugates in tissue regeneration biosynthesis, phytochelatins biosynthesis, propanethial S-oxide biosynthesis, protectin biosynthesis, protein S-nitrosylation and denitrosylation, reactive oxygen species degradation, resolvin D biosynthesis, S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II, selenate reduction, sulfide oxidation III (to sulfite), sulfide oxidation IV (mitochondria), sulfur oxidation I (aerobic), sulfur oxidation II (Fe+3-dependent), superpathway of sulfide oxidation (Acidithiobacillus ferrooxidans), trypanothione biosynthesis

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Show all BRENDA pathways known for glutathione

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3575 results)

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an (E)-omega-(methylthio)alkanal oxime + O2 + glutathione + [reduced NADPH-hemoprotein reductase] = an (E)-1-(glutathione-S-yl)-omega-(methylthio)alkylhydroximate + 2 H2O + [oxidized NADPH-hemoprotein reductase]

glutathione + ascorbate + O2 = gamma-Glu-Cys-NH2 + glyoxylate + dehydroascorbate + H2O

glutathione + H2O + O2 = ?

2 GSH + NADP+ = GSSG + NADPH + H+

724508, 726293

1.8.3.3

glutathione + O2 = glutathione disulfide + H2O2

394886, 394888, 394887

1.8.4.1

GSH + homocystine = GSSG + homocysteine

CoA-glutathione + GSH = CoA + GSSG

395011

1.8.4.4

cystine + GSH = cysteine + GSSG

395017, 395018, 395019, 395014, 395015, 395016

sulfide + glutathione = sulfur + reduced glutathione

742905

1.8.5.7

glutathione + 2-(glutathione-S-yl)-hydroquinone = glutathione disulfide + hydroquinone

glutathione + [Glu(-Cys)]n-Gly = Gly + [Glu(-Cys)]n+1-Gly

487884, 487896, 487892, 704095, 704863, 704136, 704978, 702800, 720165, 736668, 736373, 736476, 759962, 759370, 760107, 760211, 759634, 759667, 759293, 759571

2.3.2.2

5 entries

2.5.1.151

an alkylcobalamin + [alkylcobalamin reductase] + glutathione = cob(I)alamin-[alkylcobalamin reductase] + an S-alkylglutathione

thiosulfate + glutathione = sulfite + glutathione disulfide + sulfide

645570, 645571, 645572

2.8.4.6

S-methyl-1-thio-D-xylulose 5-phosphate + glutathione = 1-deoxy-D-xylulose 5-phosphate + S-(methylsulfanyl)glutathione

762723

3.4.19.9

glutathione + H2O = ?

702486

4.3.2.7

glutathione = L-cysteinylglycine + 5-oxo-L-proline

742370, 742910, 769022, 771006, 770457

4.3.2.9

glutathione = L-cysteinylglycine + 5-oxo-L-proline

glutathione/cytoplasm + ATP + H2O = glutathione/vacuole + ADP + phosphate

289187, 289191

In Vivo Product in Enzyme-catalyzed Reactions (92 results)

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1.1.1.284

S-nitrosoglutathione + NADH = GSH + NAD+ + NO

1.13.11.18

S-sulfanylglutathione + O2 = sulfite + glutathione + H+

5VE5, 3D-view

1.20.4.1

arsenate + reduced glutathione = arsenite + glutathione

3C1S, 3D-view

1.8.1.10

CoA-glutathione + NADPH = glutathione + CoA + NADP+

395107, 395012, -

1.8.1.16

glutathione disulfide + NADH + H+ = 2 glutathione + NAD+

AMP + sulfite + glutathione disulfide = adenylyl sulfate + 2 glutathione

1.8.5.4

sulfide + glutathione = sulfur + reduced glutathione

2.1.1.137

3 entries

3.1.2.12

S-formylglutathione + H2O = glutathione + formate

649455, 653164, 649219, 653549, -

3.1.2.6

6 entries

3.5.1.78

glutathionylspermidine + H2O = glutathione + spermidine

S-(hydroxymethyl)glutathione = glutathione + formaldehyde

4.4.1.5

2 entries

5.3.4.1

glutathione disulfide = glutathione

glutathione/cytoplasm + ATP + H2O = glutathione/vacuole + ADP + phosphate

7.4.2.10

ATP + H2O + glutathione-[glutathione-binding protein][side 1] = ADP + phosphate + glutathione[side 2] + [glutathione-binding protein][side 1]

Substrate in Enzyme-catalyzed Reactions (56390 results)

glutathione + H2O2 = ? + H2O

439867, 439857, 439855, 439874, 439871, 439865, 657113

glutathione + sulfite + 2 H+ = S-sulfanylglutathione + O2 + H2O

indole-3-acetaldoxime + O2 + glutathione + [reduced NADPH-hemoprotein reductase] = 1-aci-nitro-2-indolyl-ethane + H2O + [oxidized NADPH-hemoprotein reductase]

741195, 741196