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Literature summary for 2.5.1.18 extracted from
- Inhibitory effect of metals on animal and plant glutathione transferases (2020), J. Trace Elem. Med. Biol., 57, 48-56 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ag+ | - |
Alburnus tarichi |  |
| Ag+ | - |
Meleagris gallopavo | |
| Ag+ | - |
Oncorhynchus mykiss | |
| Al3+ | 68% inhibition at 100 mg/kg for male rats, 24% inhibition at 172.5 mg/kg for female rats | Rattus norvegicus | |
| As3+ | 48% inhibition at 0.5 mg/l | Laeonereis acuta | |
| As3+ | 53% inhibition at 10 mg/kg | Mus musculus | |
| AsO42- | 67% inhibition at 0.08 mM | Picea abies | |
| AsO42- | 80% inhibition at 0.05 mM | Typha latifolia | |
| Cd2+ | about 40% inhibition at 0.03 mM | Brassica juncea | |
| Cd2+ | 65% inhibition at 0.1 mM | Chelon saliens | |
| Cd2+ | 35% inhibition at 2.5 mg/kg | Mus musculus | |
| Cd2+ | 53% inhibition at 0.1 mM | Oryctolagus cuniculus | |
| Cd2+ | 90% inhibition at 1 mg/kg | Pleuronectes platessa | |
| Cd2+ | 50% inhibition at 0.05 mM | Typha latifolia | |
| Cr6+ | 58% inhibition at 10 mg/l | Pelophylax ridibundus | |
| Cu2+ | 61% inhibition at 0.1 mM | Chelon saliens | |
| Cu2+ | about 40% inhibition at 0.005 mM | Lemna minor | |
| Cu2+ | about 52% inhibition at 0.008 mM | Oryza sativa | |
| Cu2+ | 37-45% inhibition at 100-800 mg/kg | Protaetia brevitarsis | |
| dibutyltin | - |
Siganus canaliculatus | |
| Hg2+ | 70% inhibition at 0.1 mM | Chelon saliens | |
| Hg2+ | 70% inhibition at 0.0009 mg/kg | Pacifastacus leniusculus | |
| Ni2+ | 37% inhibition at 0.5 mM | Armoracia rusticana | |
| Pb2+ | 42% inhibition at 0.1 mM | Armoracia rusticana | |
| Pb2+ | 77% inhibition at 0.02 mg/l in gills, 44% inhibition at 0.02 mg/l in digestive gland | Astacus astacus | |
| Pb2+ | 74% inhibition at 0.1 mM | Oryctolagus cuniculus | |
| Pb2+ | 45% inhibition at 0.05 mM | Picea abies | |
| Pb2+ | 55% inhibition at 0.1% (w/v) | Rattus norvegicus | |
| Pb2+ | 80% inhibition at 0.05 mM | Typha latifolia | |
| Sb3+ | 69% inhibition at 0.1 mM | Chelon saliens | |
| SeO32- | 20% inhibition at 0.1 mg/l | Oreochromis mossambicus | |
| tributyltin | - |
Rhabdosargus sarba | |
| tributyltin | 70% inhibition at 0.3 mg/kg | Salvelinus alpinus | |
| tributyltin | - |
Siganus canaliculatus | |
| Triphenyltin | - |
Rhabdosargus sarba | |
| Triphenyltin | - |
Siganus canaliculatus | |
| Zn2+ | - |
Populus sp. | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Meleagris gallopavo | 5829 | - |
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Oryctolagus cuniculus | 5829 | - |
| cytosol | - |
Populus sp. | 5829 | - |
| cytosol | - |
Picea abies | 5829 | - |
| cytosol | - |
Oryza sativa | 5829 | - |
| cytosol | - |
Lemna minor | 5829 | - |
| cytosol | - |
Oncorhynchus mykiss | 5829 | - |
| cytosol | - |
Astacus astacus | 5829 | - |
| cytosol | - |
Brassica juncea | 5829 | - |
| cytosol | - |
Pleuronectes platessa | 5829 | - |
| cytosol | - |
Typha latifolia | 5829 | - |
| cytosol | - |
Pacifastacus leniusculus | 5829 | - |
| cytosol | - |
Oreochromis mossambicus | 5829 | - |
| cytosol | - |
Armoracia rusticana | 5829 | - |
| cytosol | - |
Pelophylax ridibundus | 5829 | - |
| cytosol | - |
Chelon saliens | 5829 | - |
| cytosol | - |
Alburnus tarichi | 5829 | - |
| cytosol | - |
Salvelinus alpinus | 5829 | - |
| cytosol | - |
Protaetia brevitarsis | 5829 | - |
| cytosol | - |
Laeonereis acuta | 5829 | - |
| cytosol | - |
Siganus canaliculatus | 5829 | - |
| cytosol | - |
Rhabdosargus sarba | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Alburnus tarichi | - |
- |
- |
| Armoracia rusticana | - |
- |
- |
| Astacus astacus | - |
- |
- |
| Brassica juncea | - |
- |
- |
| Chelon saliens | - |
- |
- |
| Laeonereis acuta | - |
- |
- |
| Lemna minor | - |
- |
- |
| Meleagris gallopavo | - |
- |
- |
| Mus musculus | - |
- |
- |
| Oncorhynchus mykiss | - |
- |
- |
| Oreochromis mossambicus | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Oryza sativa | - |
- |
- |
| Pacifastacus leniusculus | - |
- |
- |
| Pelophylax ridibundus | - |
- |
- |
| Picea abies | - |
- |
- |
| Pleuronectes platessa | - |
- |
- |
| Populus sp. | - |
- |
- |
| Protaetia brevitarsis | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Rhabdosargus sarba | - |
- |
- |
| Salvelinus alpinus | - |
- |
- |
| Siganus canaliculatus | - |
- |
- |
| Typha latifolia | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| digestive gland | - |
Astacus astacus | - |
| erythrocyte | - |
Oncorhynchus mykiss | - |
| gill | - |
Astacus astacus | - |
| hepatopancreas | - |
Pacifastacus leniusculus | - |
| larva | - |
Protaetia brevitarsis | - |
| liver | - |
Meleagris gallopavo | - |
| liver | - |
Chelon saliens | - |
| lung | - |
Oryctolagus cuniculus | - |
| root | - |
Oryza sativa | - |
| seedling | - |
Oryza sativa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1,2-dichloro-4-nitrobenzene | - |
Armoracia rusticana | ? | - |
? | |
| glutathione + 1,2-epoxy-3-(4-nitrophenoxy)-propane | - |
Picea abies | ? | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Meleagris gallopavo | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Mus musculus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Oryctolagus cuniculus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Populus sp. | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Oryza sativa | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Lemna minor | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Oncorhynchus mykiss | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Astacus astacus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Brassica juncea | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Pleuronectes platessa | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Typha latifolia | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Pacifastacus leniusculus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Oreochromis mossambicus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Pelophylax ridibundus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Chelon saliens | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Alburnus tarichi | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Salvelinus alpinus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Protaetia brevitarsis | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Laeonereis acuta | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Siganus canaliculatus | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rhabdosargus sarba | chloride + 2,4-dinitrophenyl-glutathione | - |
? | |
| glutathione + ethacrynic acid | - |
Chelon saliens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione S-transferase | - |
Meleagris gallopavo |
| glutathione S-transferase | - |
Mus musculus |
| glutathione S-transferase | - |
Rattus norvegicus |
| glutathione S-transferase | - |
Oryctolagus cuniculus |
| glutathione S-transferase | - |
Populus sp. |
| glutathione S-transferase | - |
Picea abies |
| glutathione S-transferase | - |
Oryza sativa |
| glutathione S-transferase | - |
Lemna minor |
| glutathione S-transferase | - |
Oncorhynchus mykiss |
| glutathione S-transferase | - |
Astacus astacus |
| glutathione S-transferase | - |
Brassica juncea |
| glutathione S-transferase | - |
Pleuronectes platessa |
| glutathione S-transferase | - |
Typha latifolia |
| glutathione S-transferase | - |
Pacifastacus leniusculus |
| glutathione S-transferase | - |
Oreochromis mossambicus |
| glutathione S-transferase | - |
Armoracia rusticana |
| glutathione S-transferase | - |
Pelophylax ridibundus |
| glutathione S-transferase | - |
Chelon saliens |
| glutathione S-transferase | - |
Alburnus tarichi |
| glutathione S-transferase | - |
Salvelinus alpinus |
| glutathione S-transferase | - |
Protaetia brevitarsis |
| glutathione S-transferase | - |
Laeonereis acuta |
| glutathione S-transferase | - |
Siganus canaliculatus |
| glutathione S-transferase | - |
Rhabdosargus sarba |
| GST | - |
Meleagris gallopavo |
| GST | - |
Mus musculus |
| GST | - |
Rattus norvegicus |
| GST | - |
Oryctolagus cuniculus |
| GST | - |
Populus sp. |
| GST | - |
Picea abies |
| GST | - |
Oryza sativa |
| GST | - |
Lemna minor |
| GST | - |
Oncorhynchus mykiss |
| GST | - |
Astacus astacus |
| GST | - |
Brassica juncea |
| GST | - |
Pleuronectes platessa |
| GST | - |
Typha latifolia |
| GST | - |
Pacifastacus leniusculus |
| GST | - |
Oreochromis mossambicus |
| GST | - |
Armoracia rusticana |
| GST | - |
Pelophylax ridibundus |
| GST | - |
Chelon saliens |
| GST | - |
Alburnus tarichi |
| GST | - |
Salvelinus alpinus |
| GST | - |
Protaetia brevitarsis |
| GST | - |
Laeonereis acuta |
| GST | - |
Siganus canaliculatus |
| GST | - |
Rhabdosargus sarba |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0004 | - |
pH and temperature not specified in the publication | Meleagris gallopavo | Ag+ | |
| 0.00092 | - |
pH and temperature not specified in the publication | Siganus canaliculatus | tributyltin | |
| 0.0018 | - |
pH and temperature not specified in the publication | Rhabdosargus sarba | Triphenyltin | |
| 0.0032 | - |
pH and temperature not specified in the publication | Siganus canaliculatus | dibutyltin | |
| 0.0035 | - |
pH and temperature not specified in the publication | Rhabdosargus sarba | tributyltin | |
| 0.004 | - |
pH and temperature not specified in the publication | Siganus canaliculatus | Triphenyltin | |
| 0.011 | - |
pH and temperature not specified in the publication | Alburnus tarichi | Ag+ | |
| 0.035 | - |
pH and temperature not specified in the publication | Oncorhynchus mykiss | Ag+ | |
| 0.05 | - |
pH and temperature not specified in the publication | Typha latifolia | Cd2+ | |
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