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Information on EC 2.4.1.281 - 4-O-beta-D-mannosyl-D-glucose phosphorylase
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EC Tree
2.4.1.281 4-O-beta-D-mannosyl-D-glucose phosphorylaseIUBMB Comments
This enzyme forms part of a mannan catabolic pathway in the anaerobic bacterium Bacteroides fragilis NCTC 9343.
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Word Map
- 2.4.1.281
- calcitonin
-
receptor-like
- adrenomedullin
-
gene-related
-
activity-modifying
- camp
-
vasodilator
- amylin
- endothelial
- artery
-
neuropeptide
-
receptor-activity-modifying
- migraine
-
protein-coupled
-
calcitonin-receptor-like
-
cgrp-induced
-
intermedin
-
gpcrs
-
calcitonin-like
-
cgrp-mediated
-
trigeminovascular
-
bibn4096bs
-
trigeminal
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calcitonin-gene-related
-
receptor-activity
-
hypotensive
-
cgrp-receptors
-
am-induced
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calcrl
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
ramp1, ramp2, bf0772, 
more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
BF0772
MP1
RaMp1
RaMp2
Rumal_0852
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate
-
-
-
-
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate
sequential Bi Bi mechanism
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate
sequential bi-bi mechanism involving ternary complex formation
-
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate
sequential Bi Bi mechanism
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-
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PATHWAY SOURCE
PATHWAYS
-
-
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SYSTEMATIC NAME
IUBMB Comments
4-O-beta-D-mannopyranosyl-D-glucopyranose:phosphate alpha-D-mannosyltransferase
This enzyme forms part of a mannan catabolic pathway in the anaerobic bacterium Bacteroides fragilis NCTC 9343.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
1,5-anhydro-D-glucitol + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-1,5-anhydro-D-glucitol + phosphate
1,5-anhydro-D-glucitol + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
-
r
2-deoxy-2-fluoro-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-2-deoxy-2-fluoro-D-glucopyranose + phosphate
-
-
-
r
2-deoxy-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-2-deoxy-D-glucopyranose + phosphate
-
-
-
r
3-deoxy-3-fluoro-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-3-deoxy-3-fluoro-D-glucopyranose + phosphate
-
-
-
r
3-O-methyl-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-3-O-methyl-D-glucopyranose + phosphate
-
-
-
r
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
6-deoxy-6-fluoro-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-6-fluoro-D-glucopyranose + phosphate
6-deoxy-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-D-glucopyranose + phosphate
cellobiose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
r
D-allose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-allose + phosphate
-
-
-
r
D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-mannose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-mannopyranose + phosphate
-
-
-
r
D-xylose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-xylopyranose + phosphate
-
-
-
-
r
gentiobiose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
r
methyl alpha-D-glucoside + alpha-D-mannose 1-phosphate
methyl [4-O-beta-D-mannopyranosyl]-alpha-D-glucoside + phosphate
-
-
-
r
methyl beta-D-glucoside + alpha-D-mannose 1-phosphate
methyl [4-O-beta-D-mannopyranosyl]-beta-D-glucopyranoside + phosphate
N,N'-diacetylchitobiose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
r
N-acetyl-D-glucosamine + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate
-
-
-
r
sophorose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
r
1,5-anhydro-D-glucitol + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-1,5-anhydro-D-glucitol + phosphate
-
-
-
r
1,5-anhydro-D-glucitol + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-1,5-anhydro-D-glucitol + phosphate
-
-
-
r
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
phosphorolysis reaction
-
-
r
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
-
-
-
-
r
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
-
-
-
r
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
-
-
-
r
6-deoxy-6-fluoro-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-6-fluoro-D-glucopyranose + phosphate
-
-
-
?
6-deoxy-6-fluoro-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-6-fluoro-D-glucopyranose + phosphate
-
-
-
?
6-deoxy-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-D-glucopyranose + phosphate
-
-
-
-
r
6-deoxy-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-D-glucopyranose + phosphate
-
-
-
?
6-deoxy-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-D-glucopyranose + phosphate
-
-
-
?
D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
-
-
-
-
r
D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
-
-
-
r
D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
-
-
-
?
D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
-
-
-
?
D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
-
-
-
r
laminaribiose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
r
laminaribiose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
?
laminaribiose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
r
laminaribiose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
?
methyl beta-D-glucoside + alpha-D-mannose 1-phosphate
methyl [4-O-beta-D-mannopyranosyl]-beta-D-glucopyranoside + phosphate
-
-
-
-
r
methyl beta-D-glucoside + alpha-D-mannose 1-phosphate
methyl [4-O-beta-D-mannopyranosyl]-beta-D-glucopyranoside + phosphate
-
-
-
r
additional information
?
-
no substrates are 4-O-beta-D-xylopyranosyl-D-xylose, sophorose, sucrose, laminaribiose, cellobiose, lactose, epilactose, 4-O-beta-D-mannopyranosyl-D-mannose, gentiobiose, kojibiose, nigerose, maltose, isomaltose.
-
-
?
additional information
?
-
The enzyme also catalyzes the reaction of beta-1,4-mannooligosaccharide phosphorylase
-
-
?
additional information
?
-
The enzyme also catalyzes the reaction of beta-1,4-mannooligosaccharide phosphorylase
-
-
?
additional information
?
-
-
The enzyme also catalyzes the reaction of beta-1,4-mannooligosaccharide phosphorylase
-
-
?
additional information
?
-
The enzyme also catalyzes the reaction of beta-1,4-mannooligosaccharide phosphorylase
-
-
?
additional information
?
-
The enzyme also catalyzes the reaction of beta-1,4-mannooligosaccharide phosphorylase
-
-
?
additional information
?
-
-
The enzyme also catalyzes the reaction of beta-1,4-mannooligosaccharide phosphorylase
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
6-deoxy-6-fluoro-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-6-fluoro-D-glucopyranose + phosphate
6-deoxy-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
phosphorolysis reaction
-
-
r
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
-
-
-
r
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
D-glucose + alpha-D-mannose 1-phosphate
-
-
-
r
6-deoxy-6-fluoro-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-6-fluoro-D-glucopyranose + phosphate
-
-
-
?
6-deoxy-6-fluoro-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-6-fluoro-D-glucopyranose + phosphate
-
-
-
?
6-deoxy-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-D-glucopyranose + phosphate
-
-
-
?
6-deoxy-D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-6-deoxy-D-glucopyranose + phosphate
-
-
-
?
D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
-
-
-
r
D-glucose + alpha-D-mannose 1-phosphate
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate
-
-
-
r
laminaribiose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
?
laminaribiose + alpha-D-mannose 1-phosphate
? + phosphate
-
-
-
?
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
4-o-beta-d-mannosyl-d-glucose phosphorylase deficiency
The CGRP receptor component RAMP1 links sensory innervation with YAP activity in the regenerating liver.
Adenocarcinoma of Lung
Abnormal gene expression and gene fusion in lung adenocarcinoma with high-throughput RNA sequencing.
Adenomyosis
Possible involvement of neuropeptide and neurotransmitter receptors in Adenomyosis.
Asthma
Expression of functional receptor activity modifying protein 1 by airway epithelial cells with dysregulation in asthma.
Brain Ischemia
Pathophysiological roles of adrenomedullin-RAMP2 system in acute and chronic cerebral ischemia.
Carcinogenesis
RAMP1 Is a Direct NKX3.1 Target Gene Up-Regulated in Prostate Cancer that Promotes Tumorigenesis.
Carcinoma
Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line.
Carcinoma, Hepatocellular
Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.
Cardiomyopathies
Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia.
Cardiovascular Diseases
Changes of adrenomedullin and receptor activity modifying protein 2 (RAMP2) in myocardium and aorta in rats with isoproterenol-induced myocardial ischemia.
Cardiovascular Diseases
Endothelial Restoration of Receptor Activity-Modifying Protein 2 Is Sufficient to Rescue Lethality, but Survivors Develop Dilated Cardiomyopathy.
Cardiovascular Diseases
Regulation of adrenomedullin and its family peptide by RAMP system--lessons from genetically engineered mice.
Cardiovascular Diseases
Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction.
Cerebral Infarction
Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction.
Colitis
RAMP1 suppresses mucosal injury from dextran sodium sulfate-induced colitis in mice.
COVID-19
Circulating Levels of Calcitonin Gene-Related Peptide Are Lower in COVID-19 Patients.
Diabetes Mellitus, Type 1
The role of adrenomedullin and receptors in glomerular hyperfiltration in streptozotocin-induced diabetic rats.
Endometriosis
Inhibition of receptor activity-modifying protein 1 suppresses the development of endometriosis and the formation of blood and lymphatic vessels.
Essential Hypertension
Haplotype-based, case-control study of the receptor (calcitonin) activity-modifying protein (RAMP) 1 gene in essential hypertension.
Fetal Death
Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice.
Fetal Growth Retardation
Research resource: Haploinsufficiency of receptor activity-modifying protein-2 (RAMP2) causes reduced fertility, hyperprolactinemia, skeletal abnormalities, and endocrine dysfunction in mice.
Glaucoma, Open-Angle
Mutant RAMP2 causes primary open-angle glaucoma via the CRLR-cAMP axis.
Glomerulonephritis
Adrenomedullin (AM) and receptor-activity-modifying proteins in glomeruli with Thy.1 glomerulonephritis.
Heart Failure
Increased gene expression of adrenomedullin and adrenomedullin-receptor complexes, receptor-activity modifying protein (RAMP)2 and calcitonin-receptor-like receptor (CRLR) in the hearts of rats with congestive heart failure.
Heart Failure
Increased myocardial expression of RAMP1 and RAMP3 in rats with chronic heart failure.
Heart Failure
[Increased atria expression of receptor activity-modifying proteins in heart failure patients]
Hepatitis B, Chronic
Treated with interferon and the gene polymorphism of CGRP and its receptor.
Hyperalgesia
Expression of ASIC3 in the Trigeminal Nucleus Caudalis Plays a Role in a Rat Model of Recurrent Migraine.
Hyperalgesia
Genetic enhancement of calcitonin gene-related Peptide-induced central sensitization to mechanical stimuli in mice.
Hypertension
Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction.
Hypertension
Receptor activity-modifying protein 1 increases baroreflex sensitivity and attenuates Angiotensin-induced hypertension.
Hypertension, Pulmonary
[Changes of intermedin/adrenomedullin 2 and its receptors in the right ventricle of rats with chronic hypoxic pulmonary hypertension.]
Infertility
Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age.
Liver Cirrhosis
Cirrhosis decreases vasoconstrictor response to electrical field stimulation in rat mesenteric artery: role of calcitonin gene-related peptide.
Liver Cirrhosis
The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl4-induced rat liver cirrhosis.
Lung Neoplasms
Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation.
Migraine Disorders
Aberrant DNA methylation pattern may enhance susceptibility to migraine: A novel perspective.
Migraine Disorders
Association study of the calcitonin gene-related polypeptide-alpha (CALCA) and the receptor activity modifying 1 (RAMP1) genes with migraine.
Migraine Disorders
CGRP Signaling via CALCRL Increases Chemotherapy Resistance and Stem Cell Properties in Acute Myeloid Leukemia.
Migraine Disorders
Immunohistochemical localization of the calcitonin gene-related peptide binding site in the primate trigeminovascular system using functional antagonist antibodies.
Migraine Disorders
Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine.
Migraine Disorders
Sensitization of calcitonin gene-related peptide receptors by receptor activity-modifying protein-1 in the trigeminal ganglion.
Neoplasm Metastasis
Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts.
Neoplasm Metastasis
Expression of adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenograft growth in vivo.
Neoplasm Metastasis
The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis.
Neoplasms
Adrenomedullin 2 attenuates LPS-induced inflammation in microglia cells by receptor-mediated cAMP-PKA pathway.
Neoplasms
Adrenomedullin blockade suppresses growth of human hormone independent prostate tumor xenograft in mice.
Neoplasms
Deficiency of the adrenomedullin-RAMP3 system suppresses metastasis through the modification of cancer-associated fibroblasts.
Neoplasms
Expression of adrenomedullin 2/intermedin in human adrenal tumors and attached non-neoplastic adrenal tissues.
Neoplasms
Expression of adrenomedullin in human colorectal tumors and its role in cell growth and invasion in vitro and in xenograft growth in vivo.
Neoplasms
Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation.
Neoplasms
Neuropeptide-induced modulation of carcinogenesis in a metastatic breast cancer cell line (MDA-MB-231LUC+).
Neoplasms
RAMP1 Is a Direct NKX3.1 Target Gene Up-Regulated in Prostate Cancer that Promotes Tumorigenesis.
Neoplasms
The endothelial adrenomedullin-RAMP2 system regulates vascular integrity and suppresses tumour metastasis.
Neuroblastoma
Differential expression of adrenomedullin and its receptor component, receptor activity modifying protein (RAMP) 2 during hypoxia in cultured human neuroblastoma cells.
Pancreatic Neoplasms
Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion.
Pancreatic Neoplasms
Adrenomedullin promotes the growth of pancreatic ductal adenocarcinoma through recruitment of myelomonocytic cells.
Pancreatitis
The neuropeptide receptor subunit RAMP1 constrains the innate immune response during acute pancreatitis in mice.
Periodontitis
Gene expression analysis of neuropeptides in oral mucosa during periodontal disease in non-human primates.
Peritonitis
Deficiency of the CGRP receptor component RAMP1 attenuates immunosuppression during the early phase of septic peritonitis.
Photophobia
Role of calcitonin gene-related peptide in light-aversive behavior: implications for migraine.
Pre-Eclampsia
Evidence for decreased calcitonin gene-related peptide (CGRP) receptors and compromised responsiveness to CGRP of fetoplacental vessels in preeclamptic pregnancies.
Pre-Eclampsia
Placental gene expression of calcitonin gene-related peptide and nitric oxide synthases in preeclampsia: effects of magnesium sulfate.
Prostatic Neoplasms
Adrenomedullin blockade suppresses growth of human hormone independent prostate tumor xenograft in mice.
Prostatic Neoplasms
RAMP1 Is a Direct NKX3.1 Target Gene Up-Regulated in Prostate Cancer that Promotes Tumorigenesis.
Pulmonary Fibrosis
Regulation of myofibroblast differentiation and bleomycin-induced pulmonary fibrosis by adrenomedullin.
Thyroid Neoplasms
Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line.
Ureteral Obstruction
Intermedin is upregulated and attenuates renal fibrosis by inhibition of oxidative stress in rats with unilateral ureteral obstruction.
Ureteral Obstruction
Rat receptor-activity-modifying proteins (RAMPs) for adrenomedullin/CGRP receptor: cloning and upregulation in obstructive nephropathy.
Vascular Calcification
Alterations of adrenomedullin and its receptor system components in calcified vascular smooth muscle cells.
Vascular Diseases
Receptor activity-modifying protein-1 augments cerebrovascular responses to calcitonin gene-related peptide and inhibits angiotensin II-induced vascular dysfunction.
Wiskott-Aldrich Syndrome
Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
79.2
1,5-anhydro-D-glucitol
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
48.7
2-deoxy-2-fluoro-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
90.7
2-deoxy-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
6.44
3-deoxy-3-fluoro-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
7.82
3-O-methyl-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
156
6-deoxy-6-fluoro-D-glucose
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
119
6-deoxy-D-glucose
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
22.2
cellobiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
6.14
D-allose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
45.6
D-mannose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
60.8
gentiobiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
29.1
laminaribiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
50.4
maltose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
85.3
methyl alpha-D-glucoside
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
85.2
methyl beta-D-glucoside
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
49.9
N,N'-diacetylchitobiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
107
N-acetyl-D-glucosamine
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
49.8
sophorose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.304
4-O-beta-D-mannopyranosyl-D-glucopyranose
pH 6.5, 37°C, phosphorolytic reaction, cosubstrate phosphate
27.7
4-O-beta-D-mannopyranosyl-D-glucopyranose
pH 6.5, 37°C, phosphorolytic reaction, cosubstrate phosphate
0.324
alpha-D-mannose 1-phosphate
pH 6.5, 37°C, synthetic reaction, cosubstrate D-glucose
5.8
alpha-D-mannose 1-phosphate
pH 6.5, 37°C, synthetic reaction, cosubstrate D-glucose
38.2
D-glucose
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
172
D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.444
phosphate
pH 6.5, 37°C, phosphorolytic reaction, cosubstrate 4-O-beta-D-mannopyranosyl-D-glucopyranose
5.34
phosphate
pH 6.5, 37°C, phosphorolytic reaction, cosubstrate 4-O-beta-D-mannopyranosyl-D-glucopyranose
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
20.7
1,5-anhydro-D-glucitol
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
5.71
2-deoxy-2-fluoro-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
11.7
2-deoxy-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.94
3-deoxy-3-fluoro-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.763
3-O-methyl-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
42
6-deoxy-6-fluoro-D-glucose
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
177
6-deoxy-D-glucose
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
20.2
cellobiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.667
D-allose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
5.12
D-mannose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
26.1
gentiobiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
11.6
laminaribiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
5.07
maltose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
20.7
methyl alpha-D-glucoside
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
35.2
methyl beta-D-glucoside
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
6.34
N,N'-diacetylchitobiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
15.8
N-acetyl-D-glucosamine
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
13.8
sophorose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
17.5
4-O-beta-D-mannopyranosyl-D-glucopyranose
pH 6.5, 37°C, phosphorolytic reaction, cosubstrate phosphate
83.3
4-O-beta-D-mannopyranosyl-D-glucopyranose
pH 6.5, 37°C, phosphorolytic reaction, cosubstrate phosphate
34.5
D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
45.1
D-glucose
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.261
1,5-anhydro-D-glucitol
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.117
2-deoxy-2-fluoro-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.129
2-deoxy-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.146
3-deoxy-3-fluoro-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.0976
3-O-methyl-D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.269
6-deoxy-6-fluoro-D-glucose
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
1.49
6-deoxy-D-glucose
pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.91
cellobiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.109
D-allose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.112
D-mannose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.429
gentiobiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.399
laminaribiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.101
maltose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.236
methyl alpha-D-glucoside
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.413
methyl beta-D-glucoside
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.127
N,N'-diacetylchitobiose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.148
N-acetyl-D-glucosamine
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.277
sophorose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
0.201
D-glucose
apparent value, pH 6.5, 37°C, synthetic reaction, cosubstrate alpha-D-mannose 1-phosphate
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
50
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE