Ligand D-glucopyranose

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Basic Ligand Information

Molecular Structure

C₆H₁₂O₆

D-glucopyranose

WQZGKKKJIJFFOK-GASJEMHNSA-N

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Synonyms:

(+)-glucose, a monosaccharide, Corn sugar, D(+)-glucose, D-glucopyranoside, D-glucose, D-glucose[side 2], D-glucosylpyranoside, dextrose, Glc, glucose, Grape sugar, monosaccharide, Monosaccharides

Related pathways

BRENDA

Entner Doudoroff pathway, ginsenoside metabolism, glycogen metabolism, glycolysis, metabolism of disaccharids

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KEGG

ABC transporters, AGE-RAGE signaling pathway in diabetic complications, Amino sugar and nucleotide sugar metabolism, AMPK signaling pathway, Bile secretion

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MetaCyc

1,3-propanediol biosynthesis (engineered), 2-O-acetyl-3-O-trans-coutarate biosynthesis, abscisic acid degradation by glucosylation, acylated cyanidin galactoside biosynthesis, afrormosin conjugates interconversion, ajmaline and sarpagine biosynthesis, aloesone biosynthesis II, alpha-tomatine degradation, amaranthin biosynthesis, amygdalin and prunasin degradation, anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent), anthocyanidin modification (Arabidopsis), aromatic glucosinolate activation, avenacin A-1 biosynthesis, avenacin A-2 biosynthesis, beta-(1,4)-mannan degradation, Bifidobacterium shunt, biochanin A conjugates interconversion, camptothecin biosynthesis, cellulose degradation I (cellulosome), cellulose degradation II (fungi), cichoriin interconversion, coniferin metabolism, coumarin biosynthesis (via 2-coumarate), crocetin biosynthesis, cyanidin 3,7-diglucoside polyacylation biosynthesis, cyanidin diglucoside biosynthesis (acyl-glucose dependent), cyclobis-(1rarr6)-alpha-nigerosyl degradation, daidzein conjugates interconversion, daidzin and daidzein degradation, dalcochinin biosynthesis, daphnetin modification, daphnin interconversion, des-methyl avenacin A-1 biosynthesis, dhurrin degradation, DIMBOA-glucoside activation, emetine biosynthesis, Entner-Doudoroff pathway II (non-phosphorylative), Entner-Doudoroff pathway III (semi-phosphorylative), esculetin modification, firefly bioluminescence, formononetin conjugates interconversion, fructan biosynthesis, gallotannin biosynthesis, galloylated catechin biosynthesis, GDP-alpha-D-glucose biosynthesis, genistein conjugates interconversion, ginsenoside degradation I, ginsenoside degradation II, ginsenoside degradation III, gluconeogenesis III, glucose and glucose-1-phosphate degradation, glucose degradation (oxidative), glucosinolate activation, glycogen degradation I, glycogen degradation II, glycogen degradation III (via anhydrofructose), glycolysis I (from glucose 6-phosphate), glycolysis III (from glucose), glycolysis V (Pyrococcus), heterolactic fermentation, hydroxycinnamate sugar acid ester biosynthesis, indole glucosinolate activation (herbivore attack), indole glucosinolate activation (intact plant cell), indole-3-acetate activation II, indole-3-acetate inactivation IX, kojibiose degradation, L-ascorbate biosynthesis VIII (engineered pathway), lactose and galactose degradation I, lactose degradation II, lactose degradation III, laminaribiose degradation, lampranthin biosynthesis, linamarin degradation, linustatin bioactivation, lotaustralin degradation, maackiain conjugates interconversion, maltose degradation, medicarpin conjugates interconversion, melibiose degradation, neolinustatin bioactivation, oleandomycin activation/inactivation, pentagalloylglucose biosynthesis, phenylethanol glycoconjugate biosynthesis, podophyllotoxin glucosides metabolism, proanthocyanidins biosynthesis from flavanols, procollagen hydroxylation and glycosylation, protein N-glycosylation processing phase (endoplasmic reticulum, yeast), protein N-glycosylation processing phase (plants and animals), quercetin glucoside degradation (Allium), rebeccamycin biosynthesis, rutin degradation (plants), sinapate ester biosynthesis, sorbitol biosynthesis II, starch degradation I, starch degradation II, starch degradation IV, starch degradation V, strychnine biosynthesis, sucrose biosynthesis II, sucrose degradation III (sucrose invertase), sucrose degradation V (sucrose alpha-glucosidase), sucrose degradation VII (sucrose 3-dehydrogenase), sulfoquinovose degradation IV, superpathway of hyoscyamine (atropine) and scopolamine biosynthesis, superpathway of scopolin and esculin biosynthesis, taxiphyllin bioactivation, ternatin C3 biosynthesis, trehalose biosynthesis VI, trehalose biosynthesis VII, trehalose degradation I (low osmolarity), trehalose degradation II (cytosolic), trehalose degradation IV, trehalose degradation V, trehalose degradation VI (periplasmic), tropane alkaloids biosynthesis, UDP-N-acetyl-D-galactosamine biosynthesis II, UDP-N-acetyl-D-glucosamine biosynthesis II, vindoline, vindorosine and vinblastine biosynthesis, violdelphin biosynthesis, xyloglucan degradation I (endoglucanase), xyloglucan degradation II (exoglucanase)

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Show all BRENDA pathways known for D-glucopyranose

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (69 results)

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1.1.1.118

D-glucose + NAD+ = D-glucono-1,5-lactone + NADH + H+

668049, 739713

1.1.1.119

D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH + H+

684637, 728011

1.1.1.175

D-glucose + NAD+ = ? + NADH

286115

1.1.1.2

D-glucose + NADPH + H+ = sorbitol + NADP+

D-glucose + NADP+ = D-gluconate + NADPH + H+

726594

1.1.1.431

D-glucose + NADPH + H+ = glucitol + NADP+

761007

1.1.1.432

D-glucose + NADP+ = 6-dehydro-D-glucose + NADPH + H+

D-glucose + O2 = D-glucono-1,5-lactone + H2O2

673385, 671400, 677260, 672763, 675721, 675186, 672872

1.1.3.5

D-glucose + O2 = D-glucono-1,5-lactone + H2O2

287636, 287634, 287635, 743600, 742363

1.1.3.9

D-glucosylpyranoside + O2 = D-gluco-hexodialdose + H2O2

D-glucose + O2 = ? + H2O2

724616

2.4.1.20

alpha-D-glucose 1-phosphate + D-glucose = cellobiose + phosphate

705837, 735893, 756244, 758413

2.4.1.22

4 entries

2.4.1.24

D-glucose = glucose oligomers

488994, 488993

2.4.1.245

ADP-alpha-D-glucose + D-glucose = ADP + alpha,alpha-trehalose

722972

2.4.1.281

D-glucose + alpha-D-mannose 1-phosphate = 4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate

D-glucose + beta-D-glucose 1-phosphate = alpha,alpha-trehalose + phosphate

glycerol 3-phosphate + D-glucose = glycerol + D-glucose 6-phosphate

640990

2.7.1.146

ADP + D-glucose = AMP + D-glucose 6-phosphate

ATP + D-glucose = ADP + D-glucose 6-phosphate

641064, 641065, 641066, 641057, 641063, 641069, 641062, 641053, 641056, 641054, 641055, 641059, 641058, 641060, 654181, 662022, 663374, 661779, 662836, 660934, 661401, 661139, 680495, 680502, 758654, 758660, 759161, 759749

2.7.1.61

2 entries

2.7.1.62

phosphoramidate + D-glucose = D-glucose 1-phosphate + NH3

636971

2.7.1.63

(phosphate)n + D-glucose = (phosphate)n-1 + D-glucose 6-phosphate

641755, 659420, 721367, 721374, 737862, 739015, 737557, 760392, 761859

3.2.1.22

p-nitrophenyl alpha-D-galactopyranoside + D-glucose = ?

alpha-D-Glucose 1-phosphate + D-glucose = ?

3330

7.5.2.7

ATP + H2O + D-glucose/out = ADP + phosphate + D-glucose/in

289121

In Vivo Product in Enzyme-catalyzed Reactions (260 results)

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1.1.1.265

gluconate + NAD(P)H = D-glucose + NAD(P)+

246375

2.3.1.103

1-O-sinapoyl-beta-D-glucopyranose + 1-O-sinapoyl-beta-D-glucopyranose = 1,2-di-O-sinapoyl-beta-D-glucopyranose + glucose

2.3.1.185

phenyllactylglucose + tropine = littorine + D-glucose

2.3.1.72

2 entries

2.3.1.90

1-O-galloyl-beta-D-glucose + 1-O-galloyl-beta-D-glucose = 1,6-di-O-galloyl-beta-D-glucose + D-glucose

487706, 487705, 487707

2.3.1.91

1-O-sinapoyl-beta-D-glucose + choline = D-glucose + sinapoylcholine

487711, -

cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose

2.4.1.230

2-alpha-D-glucosyl-D-glucose + phosphate = D-glucose + beta-D-glucose 1-phosphate

2.4.1.279

2 entries

2.4.1.281

4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate

2.4.1.282

4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate

2.4.1.390

4 entries

2.4.1.64

alpha,alpha-trehalose + phosphate = D-glucose + beta-D-glucose 1-phosphate

D-glucose oxime + pyruvate = pyruvic oxime + D-glucose

D-glucose 6-phosphate + H2O = D-glucose + phosphate

3.1.3.8

D-glucose 1-phosphate + H2O = D-glucose + phosphate

3.1.3.9

D-glucose 6-phosphate + H2O = D-glucose + phosphate

652342, 652517, 650398, 653110, 650557, 649610, 651203, 652292, 649740, 649623, 649477, 649729, -

strictosidine + H2O = D-glucose + strictosidine aglycone

3.2.1.106

Glc3Man9GlcNAc2 + H2O = D-glucose + Glc2Man9GlcNAc2

raucaffricine + H2O = D-glucose + vomilenine

488937, 488938, -

3.2.1.126

4 entries

3.2.1.133

acarbose + H2O = glucose + acarviosine-glucose

3-O-[alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc]diosgenin + 3 H2O = D-glucopyranose + 2 L-rhamnopyranose + diosgenin

ginsenoside Re + H2O = ginsenoside Rh1 + D-glucose + L-rhamnose

3.2.1.20

2 entries

3.2.1.205

isomaltose + H2O = beta-D-glucose + D-glucose

2-O-(alpha-D-glucopyranosyl)-D-glycerate + H2O = D-glucopyranose + D-glycerate

3.2.1.21

11 entries

3.2.1.216

kojibiose + H2O = beta-D-glucopyranose + D-glucopyranose

beta-1,3-glucan + H2O = laminaribiose + D-glucose

3.2.1.41

pullulan + H2O = glucose + maltose + maltotriose + maltotetraose

3.2.1.42

GDP-glucose + H2O = GDP + D-glucose

laminarin + H2O = laminaribiose + D-glucose

alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate

134592, 137013, 137014

3.2.1.94

glucooligosaccharides + H2O = isomaltose + D-glucose

3-O-beta-D-glucopyranosyl-D-glucopyranose + H2O = beta-D-glucose + D-glucose

pyridoxine-5'-beta-D-glucoside + H2O = pyridoxine + D-glucose

ATP + H2O + D-glucose/out = ADP + phosphate + D-glucose/in

289121

Substrate in Enzyme-catalyzed Reactions (501 results)

D-glucose + NAD+ = ?

D-glucose + NAD+ = D-glucono-1,5-lactone + NADH + H+

D-glucose + NADH = ?

D-glucose + NADPH = ?

389394

1.1.1.149

D-glucose + NADPH = NADP+ + ?

286000

1.1.1.175

D-glucose + NAD+ = ? + NADH

D-glucose + NAD+ = D-gluconate + NADH

389431, 389430

1.1.1.19

D-glucose + NADPH + H+ = D-glucitol + NADP+

D-glucose + NADPH = ? + NADP+

D-glucose + NAD+ = 3-dehydro-D-glucose + NADH + H+

725212

1.1.1.365

D-glucose + NADPH + H+ = ?

724580

1.1.1.424

D-glucose + NADP+ = D-gluconolactone + NADPH + H+

D-glucose + NADP+ = 6-dehydro-D-glucose + NADPH + H+

D-glucose + NAD(P)+ = D-gluconate + NAD(P)H

287008

1.1.1.69

D-glucose + ? = 5-keto-D-gluconic acid + ?

667291, 654319, 669549

1.1.1.71

D-glucose + NADP+ = ? + NADPH + H+

726712

1.1.1.72

D-glucose + NADPH = sorbitol + NADP+

287283

1.1.1.75

D-glucose + NADP+ = ? + NADPH + H+

695805

1.1.2.11

D-glucose + phenazine methosulfate = 3-dehydro-D-gluose + reduced phenazine methosulfate

D-glucose + O2 = 2-dehydro-D-glucose + H2O2

389650

1.1.3.13

glucose + O2 = ? + H2O2

D-glucose + O2 = D-glucono-1,5-lactone + H2O2

287636, 287638, 287639, 287634, 287635, 287637, 673543, 743600, 742363

1.1.3.8

2 entries

1.1.3.9

D-glucosylpyranoside + O2 = D-gluco-hexodialdose + H2O2

D-glucose + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol

D-glucose + 2,6-dichlorophenolindophenol = ? + reduced 2,6-dichlorophenolindophenol

glucose + phosphate + NAD+ = ? + NADH

287913

1.2.1.3

D-glucose + NAD+ + H2O = D-glucuronic acid + NADH

348712

1.2.1.88

D-glucose + NAD+ + H2O = D-gluconate + NADH

392065

1.2.1.92

D-glucose + NADP+ + H2O = ?

763358

1.3.1.20

D-glucose + NADP+ = D-glucono-1,5-lactone + NADPH + H+

selenate + glucose = ?

644812

2.2.1.3

D-xylulose 5-phosphate + D-glucose = glyceraldehyde 3-phosphate + D-glycero-D-ido-oct-2-ulose

486051

2.3.1.122

alpha,alpha-trehalose monomycolate + D-glucose = D-glucose monomycolate + alpha,alpha-trehalose

702229, 704439

2.3.1.79

acetyl-CoA + D-glucose = CoA + acetyl-D-glucose

UDP-glucose + glucose = ? + UDP

488404

2.4.1.13

UDP-alpha-D-glucose + D-glucose = ?

703490

2.4.1.15

UDP-glucose + D-glucose = UDP + ?

starch + D-glucose = maltose + isomaltose

D-glucose = glucose oligomers

D-glucose + alpha-D-mannose 1-phosphate = 4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate

725502, 735796, 736111

2.4.1.30

D-glucose + alpha-D-glucose 1-phosphate = laminaribiose + phosphate

UDPgalactose + glucose = lactose + UDP

489493, 489496, 489525, 489519, 489529, 489521, 489530, 489535, 489526, 489538, 489554, 489546, 489553, 489543

UDP-D-xylose + D-glucose = UDP + Xylalpha(1-3)Glc

ADP + D-glucose = AMP + D-glucose 6-phosphate

761560

2.7.1.121

phosphohistidinoprotein + D-glucose = histidine-containing protein + D-glucose phosphate

640691

2.7.1.142

glycerol 3-phosphate + D-glucose = glycerol + D-glucose 6-phosphate

ATP + D-glucose = ADP + D-glucose 1-phosphate

737343

2.7.1.17

ATP + D-glucose = ADP + D-glucose 6-phosphate

ATP + D-glucose = ADP + D-glucose 6-phosphate

641477, 641484, 663153, 675666, 641487

2.7.1.52

ATP + D-glucose = ?

641674, 641670

2.7.1.55

ATP + D-glucose = ADP + D-glucose 6-phosphate

636977

2.7.1.59

ATP + D-glucose = ADP + D-glucose 6-phosphate

641697, 641698, 641692, 641691, 641702, 659055, 739411, 738241

2.7.1.6

ATP + D-glucose = ADP + alpha-D-glucose 1-phosphate

661467, 674579, 721813, 759133

2.7.1.60

ATP + D-glucose = ADP + D-glucose 6-phosphate

phosphoramidate + D-glucose = D-glucose 1-phosphate + NH3

ATP + D-glucose = ADP + D-glucose 6-phosphate

761787

2.7.1.85

ATP + D-glucose = ADP + D-glucose 6-phosphate

642061

2.8.2.22

4-nitrophenyl sulfate + D-glucose = ?

723897

3.1.1.6

D-glucose + vinyl acetate = 6-O-acetyl-D-glucopyranose + vinyl alcohol

715029

3.1.1.73

ferulic acid + D-glucose = ?

phosphatidylcholine + D-glucose = phosphatidylglucose + choline

D-glucose + maltooligosaccharide = maltooligosaccharide

136805, 171371, 171374

3.2.1.45

D-glucose + cholesterol = ?

glucose + H2O = ?

D-glucose + H2O = ?

glucose + H2O = ?

Galbeta(1-3)GalNAcalpha(1-)p-nitrophenyl + glucose = ?

208869

3.2.1.B28

D-glucose = gluco-oligosaccharides + H2O

D-glucose = D-mannose

713921, 727227, 747378, 774407

3wki, 3D-view

5.1.3.2

D-glucose = D-galactose

D-glucose = ?

D-glucose = ?

D-glucose = ?

ATP + H2O + D-glucose/out = ADP + phosphate + D-glucose/in

289121

7.5.2.B8

ATP + H2O + D-glucose/out = ADP + phosphate + D-glucose/in

720226, 719692, 720227, 724273

Product in Enzyme-catalyzed Reactions (1878 results)

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1.1.1.138

D-glucitol + NADP+ = D-glucose + NADPH + H+

1.1.1.265

gluconate + NAD(P)H = D-glucose + NAD(P)+

246375

1.1.1.432

6-dehydro-D-glucose + NADPH + H+ = D-glucose + NADP+

1.1.3.40

D-glucitol + O2 = D-glucose + H2O2

1.1.99.12

D-sorbitol + acceptor = D-glucose + D-gluconic acid + L-sorbose + reduced acceptor

1-O-galloyl-beta-D-glucose + 1,2,3,6-tetra-O-galloyl-beta-D-glucose = D-glucose + 1,2,3,4,6-penta-O-galloyl-beta-D-glucose

2 sucrose = D-glucose + beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside

isomaltooligosaccharide = glucose + isomaltooligosaccharides

beta-D-galactosyl-(1->3)-D-glucose + phosphate = D-glucose + alpha-D-galactose 1-phosphate

4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate

2.4.1.282

4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate

2.4.1.30

laminaribiose + phosphate = D-glucose + alpha-D-glucose 1-phosphate

489042, -

2.4.1.31

2 entries

2.4.1.319

4-O-beta-D-mannosyl-D-glucose + phosphate = D-glucose + alpha-D-mannosyl 1-phosphate

2.4.1.362

2 entries

2.4.1.373

sucrose = D-glucose + leucrose + ?

cellobiose + phosphate = alpha-D-glucose 1-phosphate + D-glucose

2.4.1.64

3 entries

2.4.1.7

glycosyl-glucose + arsenate = glucose-1-arsenate + glucose

acarviosyl glucose + maltose = acarviosyl-alpha-(1->4)-maltose + D-glucose

2.6.3.1

D-glucose oxime + pyruvate = pyruvic oxime + D-glucose

640203

2.7.1.147

AMP + D-glucose 6-phosphate = ADP + D-glucose

2.7.1.41

D-glucose 1-phosphate + D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate

641628, 641629, 641630

2.7.1.42

3 entries

2.7.1.61

D-glucose + D-glucose 1-phosphate = D-glucose 6-phosphate + D-glucose

2.7.1.77

glucose 6-phosphate + inosine = D-glucose + IMP

3.1.1.20

13 entries

3.1.1.33

6-acetyl-D-glucose + H2O = glucose + acetate

80882

3.1.1.41

D-glucose pentaacetate + H2O = D-glucose + acetate

3.1.1.72

4 entries

3.1.1.73

4-nitrophenyl beta-D-glucopyranoside + H2O = 4-nitrophenol + D-glucopyranose

alpha-D-glucose 6-phosphate + H2O = D-glucose + phosphate

3.1.3.104

D-glucose 6-phosphate + H2O = D-glucose + phosphate

3.1.3.11

2 entries

3.1.3.110

D-glucose 6'-phosphate + H2O = D-glucose + phosphate

3.1.3.12

D-glucose 6-phosphate + H2O = D-glucose + phosphate

3.1.3.2

8 entries

3.1.3.20

Glucose 6-phosphate + H2O = Glucose + phosphate

glucose 1-phosphate + H2O = glucose + phosphate

3.1.3.38

Glucose 6-phosphate + H2O = Glucose + phosphate

3.1.3.4

Glucose 6-phosphate + H2O = Glucose + phosphate

3.1.3.5

D-glucose 6-phosphate + H2O = D-glucose + phosphate

3.1.3.58

2 entries

3.1.3.60

D-glucose 6-phosphate + H2O = D-glucose + phosphate

3.1.3.68

Glucose 6-phosphate + H2O = Glucose + phosphate

dolichyl beta-D-glucosyl phosphate + H2O = dolichyl phosphate + D-glucose

646470

3.1.4.B4

UDP-alpha-D-glucose + H2O = UDP + D-glucose

3.1.6.14

glucose 6-sulfate + H2O = glucose + sulfate

3.1.6.3

3 entries

3.1.7.1

glucose-6-phosphate + H2O = glucose + phosphate

lacto-N-tetraose + H2O = glucose + Galbeta(1-3)GlcNAcbeta(1-3)Gal

208415, -

4-nitrophenyl beta-D-glucopyranoside + H2O = 4-nitrophenol + D-glucose

Remazol brilliant blue-carboxymethylcellulose + H2O = glucose + cellobiose + cellotriose + cellotetraose + high-molecular-mass oligosaccharides

3.2.1.14

p-nitrophenyl-beta-D-glucopyranoside + H2O = D-glucopyranose + p-nitrophenol

sucrose + H2O = D-fructose + D-glucose

3.2.1.154

sucrose + H2O = D-fructose + D-glucose

3.2.1.161

3 entries

3.2.1.165

4-methylumbelliferyl beta-D-glucoside + H2O = 4-methylumbelliferol + D-glucose

oligoxanthan + H2O = D-glucose + glucuronate

isomaltose + H2O = beta-D-glucose + D-glucose

2-O-(alpha-D-glucopyranosyl)-D-glycerate + H2O = D-glucopyranose + D-glycerate

GDP-glucose + H2O = GDP + D-glucose

4-nitrophenyl beta-D-glucopyranoside + H2O = 4-nitrophenol + D-glucopyranose

sucrose + H2O = D-fructose + D-glucose

3.2.1.68

panose + H2O = D-glucose + maltose

aesculin + H2O = aesculetin + D-glucose

sucrose + H2O = D-glucose + D-fructose

4-nitrophenyl beta-D-glucopyranoside + H2O = 4-nitrophenol + D-glucopyranose

3.2.1.B36

2 entries

3.2.1.B40

4-nitrophenyl beta-D-glucopyranoside + H2O = 4-nitrophenol + D-glucose

3.2.1.B41

4 entries

3.2.1.B50

4-nitrophenyl beta-D-glucoside + H2O = 4-nitrophenol + D-glucose

5-epi-2-keto-3-deoxy-D-glycero-D-galacto-nononic acid = glucose + pyruvate

4.2.2.11

9 entries

4.2.2.12

xanthan gum = monosaccharides

4.2.2.13

5 entries

4.2.2.18

1-kestose = di-D-fructofuranose 1,2':2,3'-dianhydride + D-glucose

D-galactose = D-glucose

ATP + H2O + D-glucose-[glucose-binding protein][side 1] = ADP + phosphate + D-glucose[side 2] + [glucose-binding protein][side 1]

7.5.2.2

ATP + H2O + D-glucose-[D-glucose-binding protein][side 1] = ADP + phosphate + D-glucose[side 2] + [D-glucose-binding protein][side 1]

7.5.2.7

ATP + H2O + D-glucose/out = ADP + phosphate + D-glucose/in

289121

7.5.2.B8

ATP + H2O + D-glucose/out = ADP + phosphate + D-glucose/in

Activator in Enzyme-catalyzed Reactions (93 results)

top print hide

1.1.1.146

coexpression with hexose-6-phosphate dehydrogenase potentiates 11beta-HSD1 reductase activity at high glucose, this effect is significantly decreased at low glucose, with concomitantly increased 11beta-HSD1 dehydrogenase activity

induces activity

16% activation at 2 mM

744661

1.11.1.7

slight activation in the presence of up to 1 M D-glucose

687230

1.14.18.1

11.2% activation at 2 mM

767958

1.2.3.4

physiological concentration, 20% activation free protein, 25% activation immobilized protein

288381

1.2.7.5

specific AOR activity is two to three times as high when the cells are grown with glucose in the presence of isobutanoate

oxidative stress and expression of the NADPH oxidase subunit, p22phox, are both increased, superoxide dismutase 1 and 3 expression lowered and endothelial nitric oxide synthase significantly elevated in microvessel endothelial cells treated with 40mM glucose for 72 h compared to low glucose medium. Oxidative stress, p22phox mRNA, endothelial nitric oxide synthase mRNA, and protein are lowered by concurrent incubation with sepiapterin

687930

2.3.1.20

treatment of adipocytes with glucose increases DGAT1 mRNA

1 M, 7fold stimulation

favores CGTase synthesis

488855

2.4.1.255

immunoblot analysis of OGTase expression in RASM cells. The amount of the 78 kDa subunit is significantly increased in the high glucose, but no significant increase in the amount of the 110 kDa subunit is observed. OGTase expression and activity increased in the RASM cells cultured in the 20 mM glucose

stimulate

inhibition by N-bromoacetylethanolamine

640336

2.7.1.107

exposure of L6 cell myotubes overexpressing human insulin receptors to 25 mM glucose for 5 min decreases the intracellular levels of diacylglycerol, paralleled by transient activation of diacylglycerol kinase and of insulin receptor signaling. Following 30-min exposure, both diacylglycerol levels and diacylglycerol kinase activity return close to basal levels. Glucose exposure redistributes diacylglycerol kinase isoforms alpha and delta, from the prevalent cytosolic localization to the plasma membrane fraction

increases phosphorylation of beta-catenin on Ser552 in INS-1E beta-cells

721548

2.7.11.20

high glucose or high insulin rapidly increase inactivating Ser366 phosphorylation of eEF2 kinase

stimulates, stimulation pattern of MtrA is similar to that of MtrB

1% (w/v), enhanced activity with 4-nitrophenyl acetate as substrate

695758

3.1.3.16

1.4 mM, 30°C, pH7.5, relative activity 109% with glycogen synthase D as substrate, 101% with histone as substrate, and 106% with phosphorylase a as substrate compared to no addition

50 mM, activates

the activity of 5'-nucleotidase increases with increasing D-glucose concentrations (5-30 mM) in diabetic patients

slight activation

stimulates activity 2.68fold at 40 mM

679587

3.2.1.28

activation by glucose is a reversible process

enhances activity

2 mM

1 mM, 1.07 fold activation

768832

3.2.1.52

64% activation at 3 mM

710485

3.2.1.54

0.01 M, relative activity 143%

136620

3.2.1.55

5 mM, 123% of initial activity

742926

3.2.1.8

highest specific activity of xylanase in supernatant fraction is observed in glucose culture

691953

3.2.1.B26

activated up to 2fold in the presence of D-glucose with respect to the maximum rate of glycosidic bond cleavage, measured with 2-nitrophenyl beta-D-galactoside as the substrate

724623

3.4.14.5

increases enzyme expression in glucose-treated glomerular endothelial cells, glucose effect on the enzyme is probably responsible for the reduction of glucagon-like peptide-1 in type II diabetic patients

649626

3.4.17.23

incubation of cells in high D-glucose increases ACE2 activity

732775

3.4.19.3

alters the hypothalamic activity of soluble PAP-I

682252

3.4.21.5

high glucose enhances thrombin responses through transcriptional upregulation of protease-activated receptor-4, PAR-4, mediated via PKC-beta, -delta, and NFkappaB, in human vascular smooth muscle cells

717167

3.4.22.B30

gradual increase after 3.5 days of exposure

666361

3.4.24.7

presence of high glucose levels and interferon gamma in culture medium have a synergistic effect on the expression of matrix metalloproteinases MMP-1, MMP-9 and interleukin-1beta. High glucose also enhances interferon gamma-induced priming effect on lipopolysaccharide-stimulated MMP-1 secretion. High glucose and interferon gamma exert the synergistic effect on MMP-1 expression by enhancing STAT1 phosphorylation and STAT1 transcriptional activity

695964

3.5.1.93

9% increase of activity in the presence of glucose

activates

increases Vmax, especially in presence of cations

756676

3.6.1.8

activation in preincubation

210226

4.1.1.35

activation at low substrate concentrations

4400

4.1.2.13

about 60% increase of activity

678573

4.2.1.24

incubations of erythrocytes for 24 h with glucose result in an increase of delta-ALA-D activity. Incubations of erythrocytes with 100 to 200 mM glucose for 48 h inhibit delta-ALA-D activity

677436

4.2.2.24

5 mM, 1.2fold activation

707221

4.4.1.21

expression of LuxS is increased by 0.5% (w/v) D-glucose

694032

4.4.1.5

25 mM upregulates glyoxalase I activity and mRNA in LE cells when compared with either cells cultured with 5 mM glucose as control or with 20 mM L-glucose + 5 mM D-glucose

D-glucose in concentrations of 0.1-10 mM clearly stimulates activity

11.1-16.7 mM, significant increase of enzyme expression

671236

7.1.2.1

activates, brings about a global conformational change in H+-ATPase

667643

7.2.2.11

stimulates

210289

Inhibitor in Enzyme-catalyzed Reactions (325 results)

top print hide

1.1.1.1

enzyme activity decreases to half of its original activity at 4 mg/ml of D-glucose. The thiol groups of alcohol dehydrogenase are involved in binding

excess concentration

competitive inhibition of L-glucose oxidation, Ki: 130 mM

285802

1.1.1.263

2.6% inhibition at 100 mM

207965

1.1.1.30

inhibits the enzyme when contained in the growth medium

inhibits the oxidation of gluconolactone

389643

1.1.3.4

incubation of Aspergillus niger glucose oxidase with 100 mM glucose for 8 days results in 71% loss in activity

D-glucose at different concentrations, PPO activities are measured at 25°C and pH 7.0 to determine inhibitor effects of sugars on enzymatic activities. PPO activities from both cultivars show a decreasing pattern as sugar concentration in the assay medium increases

treatment of cardiac fibroblasts with 35 mM D-glucose for 72 h reduces the PDH activity remarkably. 0.2 mM thiamine dramatically recovers the high glucose-induced PDH inhibition

712851

1.2.7.4

partially inhibited by incubation with 0.5 mM exogenous D-glucose

684549

1.3.8.13

350 mM, complete loss of activity

740464

1.3.8.4

0.15% D-glucose represses transcription

685654

2.1.1.38

reduced enzyme form, represses puromycin synthesis

strong substrate inhibition, 500 mM D-glucose reduces the enzyme activity to 49.1% of the activity at the saturating concentration of 30 mM

strong inhibition

substrate inhibition above 200 mM. At 10 mM 20% inhibition of phosphofructokinase activity

a 40fold excess of unlabeled D-glucose reduces maltose uptake to about 60-70% of the control rate

0.2 M: 84% inhibition

636988

2.7.1.59

competitive with N-acetyl-D-glucosamine

641691

2.7.1.63

above 150 mM, substrate inhibition

high levels reduce enzyme activity in vivo leading to increased thrombospondin 1-dependent activation of transforming growth factor-beta, and increased TGF-beta-dependent expression of fibronectin and collagene type IV

661566

2.7.11.19

less effective than glucose 6-phosphate, pH 8.2

492094

2.7.11.31

AMPK activity is inhibited by high glucose

701620

2.7.3.3

the enzyme is inhibited by 50 mM D-glucose, almost all arginine kinase activity is lost after treatment with 200 mM D-glucose

703776

2.7.4.3

elevated concentrations of glucose inhibit cytosolic isoform AK1 expression. Inhibition of adenylate kinase increases the ATP/ADP ratio in the microenvironment of the K/ATP channel promoting channel closure and insulin secretion

690717

2.7.8.21

5 mM, competitive to membrane-derived oligosaccharides, 78% of the activity without addition

slightly stimulating, inhibits intracellular enzyme production at concentrations above 0.05% w/v, and extracellular enzyme production above 0.1% w/v

651738

3.1.1.72

represses enzyme expression, gene axeII

Thcut1 mRNA is repressed by glucose

691941

3.1.2.1

enzyme activity is reduced in glucose-containing medium, the expression of ACH1 gene is repressed by glucose

94486

3.1.3.12

competitive inhibition of hydrolysis of glucose 6-phosphate, ineffective against hydrolysis of trehalose 6-phosphate

suppression of enzyme activity in etiolated seedling

slight

enzyme activity is suppressed by readily fermentable carbon sources such as glucose

655716

3.2.1.1

1 M, 34% inhibition. No inhibition up to 0.25 M

0.8 M: complete inhibition

488934

3.2.1.126

competitive inhibitor, p-nitrophenyl beta-D-glucopyranoside as substrate

650284

3.2.1.133

in the presence of beta-cyclodextrin the effector has a biphasic effect. While it stimulates the enzyme activity at low concentrations (with a decreasein Hill constant), it acts as allosteric inhibitor at higher concentrations

18% inhibition

10 mM, 15% inhibition

5 mM, 40% inhibition

the presence of 2% D-glucose in the medium inhibits the enzyme activity by 40 to 50%

67% inhibition at 30 mM

at 220 mM

22% inhibition at 0.7 mM, glucose product inhibition regulates the activities of both enzyme SI subunits

75% loss of activity by 2 mM

catabolite repression, even in presence of inducers

136791, 136792

3.2.1.68

10 mM, 0.4% amylose, relative activity 95%

o-nitrophenyl-beta-D-galactoside hydrolyzing activity

136936

3.2.1.91

non-competitive inhibitor

5 mM, 11% inhibition

endproduct inhibition, inhibition of enzyme activity is stronger with glucose than galactose

high concentrations

extracellular elastase activity decreases if cells are cultured in the presence of glucose

666385

3.5.1.2

negative influence in media with glucose as carbon source

non-competitive

glucose buffer, pH 11.2-12.0, progressive inactivation, complete after 1 h

246783

4.1.1.22

diminishes hdc gene expression

692809

4.1.2.33

200 mM: 42% of maximal activity

with amylopectin as substrate. No effect with glycogen as substrate

5965

4.2.2.19

represses enzyme induction in cells by chondroitin sulfate A

649356

4.3.2.1

12.5 mM glucose decreases activity of ASL by 20%, 25 mM glucose by 50%

710563

4.4.1.1

treatment with 0.025-0.035 mM H2O2, 4-8 mM acetoacetate and high D-glucose of 25 mM causes a significant decrease in enzyme protein expression, enzyme activity, and H2S levels, and an increase in intracellular reactive oxygen species production compared with those in normal controls

730038

5.1.3.2

703671