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Literature summary for 2.4.1.281 extracted from

  • Nakae, S.; Ito, S.; Higa, M.; Senoura, T.; Wasaki, J.; Hijikata, A.; Shionyu, M.; Ito, S.; Shirai, T.
    Structure of novel enzyme in mannan biodegradation process 4-O-beta-D-mannosyl-D-glucose phosphorylase MGP (2013), J. Mol. Biol., 425, 4468-4478.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
to 1.68 A resolution. The enzyme shows a homohexameric structure, which is formed by using two helices attached to the N-terminus and C-terminus as a tab for sticking between subunits. In complexes with substrates, 4-O-beta-D-mannosyl-D-glucose and phosphate, and the product D-mannose-1-phosphate the structures reveal that the invariant residue Asp131, is supposed to be the general acid/base, does not exist close to the glycosidic Glc-O4 atom, which should be protonated in the catalytic reaction Bacteroides fragilis

Organism

Organism UniProt Comment Textmining
Bacteroides fragilis Q5LH68
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Bacteroides fragilis DSM 2151 Q5LH68
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Synonyms

Synonyms Comment Organism
BF0772
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Bacteroides fragilis