Ligand alpha-D-mannose 1-phosphate

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Basic Ligand Information

Molecular Structure
Picture of alpha-D-mannose 1-phosphate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C6H13O9P
alpha-D-mannose 1-phosphate
HXXFSFRBOHSIMQ-RWOPYEJCSA-N
Synonyms:
alpha-D-mannopyranose 1-phosphate, alpha-D-mannose-1-phosphate, alpha-D-mannosyl 1-phosphate


Show all pahtways known for Show all BRENDA pathways known for alpha-D-mannose 1-phosphate

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (16 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha-D-mannose 1-phosphate + D-glucose = beta-D-mannopyranosyl-(1->3)-D-glucopyranose + phosphate
show the reaction diagram
N-acetyl-D-glucosamine + alpha-D-mannose 1-phosphate = 4-O-beta-D-mannosyl-N-acetyl-D-glucosamine + phosphate
show the reaction diagram
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GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose
show the reaction diagram
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GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
show the reaction diagram
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alpha-D-mannose 1-phosphate = D-mannose 6-phosphate
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In Vivo Product in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate
show the reaction diagram
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4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate
show the reaction diagram
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[(1->4)-beta-D-mannosyl]n + phosphate = [(1->4)-beta-D-mannosyl]n-1 + alpha-D-mannose 1-phosphate
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[(1->2)-beta-D-mannosyl]n + phosphate = [(1->2)-beta-D-mannosyl]n-1 + alpha-D-mannose 1-phosphate
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diphosphate + GDP-mannose = GTP + alpha-D-mannose 1-phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (87 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
alpha-D-mannose 1-phosphate + D-glucose = beta-D-mannopyranosyl-(1->3)-D-glucopyranose + phosphate
show the reaction diagram
GDP + alpha-D-mannose 1-phosphate = phosphate + GDP-mannose
show the reaction diagram
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ATP + alpha-D-mannose 1-phosphate = diphosphate + ADP-mannose
show the reaction diagram
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GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-alpha-D-mannopyranose
show the reaction diagram
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GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose
show the reaction diagram
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alpha-D-mannose 1-phosphate + GDP = GDP-alpha-D-mannose + phosphate
show the reaction diagram
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alpha-D-mannose 1-phosphate + H2O = alpha-D-mannose + phosphate
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alpha-D-mannopyranose 1-phosphate + H2O = alpha-D-mannose + phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (31 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate
show the reaction diagram
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4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate
show the reaction diagram
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ATP + D-mannose = ADP + alpha-D-mannose 1-phosphate
show the reaction diagram
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GDP-alpha-D-mannose + phosphate = alpha-D-mannose 1-phosphate + GDP
show the reaction diagram
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ADP-mannose + H2O = AMP + alpha-D-mannose 1-phosphate
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GDP-mannose + H2O = GMP + alpha-D-mannose 1-phosphate
show the reaction diagram
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Inhibitor in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive; competitive

3D Structure of Enzyme-Ligand-Complex (PDB) (11 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (23 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.08
-
at pH 7.0 and 45°C
33
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30°C, pH 6
22
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pH 5.0, 30°C, synthetic reaction
10.3
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pH 8.0, 37°C, cosubstrate GTP
0.0012
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pH 7.5, 26°C

KM Value (54 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
3.8
-
at pH 7.0 and 45°C
3.1
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30°C, pH 6
1.4
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pH 5.0, 30°C, synthetic reaction
0.0161
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pH 7.6, 85°C, recombinant enzyme
54
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pH 7.5, 26°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.6
-
30°C, pH 6.6

References & Links

Links to other databases for alpha-D-mannose 1-phosphate

ChEBI
PubChem
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PubChem