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EC Tree
IUBMB Comments Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on glycoproteins, glycolipids, and oligosaccharides.
The taxonomic range for the selected organisms is: Mus musculus The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
b3gnt3, b3gnt1, beta3gnt7, beta3gnt1, beta-1,3-n-acetylglucosaminyltransferase-3, beta3gn-t7, beta1-3 n-acetylglucosaminyltransferase-1, poly-n-acetyllactosamine extension enzyme, udp-glcnac:betagal beta-1,3-n-acetylglucosaminyltransferase 1, beta1,3-n-acetylglucosaminyltransferase-7,
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acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->3-
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beta1-3 N-acetylglucosaminyltransferase-1
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Galbeta1-->4GlcNAc-R beta1-->3 N-acetylglucosaminyltransferase
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i-GlcNAc transferase
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N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase
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poly-N-acetyllactosamine extension enzyme
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UDP-GlcNAc:Galbeta1-->4GlcNAcbeta-Rbeta1-->3-N-acetylglucosaminyltransferase
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UDP-GlcNAc:Galbeta1-4Glc(NAc) beta-1,3-N-acetylglucosaminyltransferase
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UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase
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uridine diphosphoacetylglucosamine-acetyllactosaminide beta1-->3-acetylglucosaminyltransferase
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hexosyl group transfer
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UDP-N-acetyl-alpha-D-glucosamine:beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R 3-beta N-acetylglucosaminyltransferase (configuration-inverting)
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on glycoproteins, glycolipids, and oligosaccharides.
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UDP-N-acetyl-D-glucosamine + asialo alpha1-acid glycoprotein
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sialic acid depleted alpha1-acid glycoprotein, 30% of the activity with neolactotetraosylceramide
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UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide
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i.e. neolactotetraosylceramide, GlcNAcT-2, synthesis in vitro of Ii core glycosphingolipids
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UDP-N-acetyl-D-glucosamine + lactosylceramide
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15% of the activity with neolactotetraosylceramide
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additional information
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additional information
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beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
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additional information
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beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
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additional information
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biosynthesis of Ii core glycosphingolipids
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additional information
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B3gnt1 null females are fertile, the B3gnt1 null males are not able to sire litters at the expected rate when mated to either wild type or B3gnt1-null females
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additional information
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additional information
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beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
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additional information
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beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
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additional information
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biosynthesis of Ii core glycosphingolipids
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additional information
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B3gnt1 null females are fertile, the B3gnt1 null males are not able to sire litters at the expected rate when mated to either wild type or B3gnt1-null females
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Ca2+
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activates, 48% as effective as Mn2+
Co2+
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activates, 52% as effective as Mn2+
Mn2+
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requirement, Km: 1.25 mM, Mn2+ cannot be replaced by Mg2+, Zn2+, Cu2+ or Cd2+
additional information
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not activated by Mg2+, Zn2+, Cu2+ or Cd2+
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detergent
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activates, reaction rate is optimal at detergent:protein ratio of 1.6 in Triton CF-54 or X-100, 1:3 in Nonidet P-40
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Nonidet P-40
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reaction rate is optimal at detergent:protein ratio of 1:3
Triton CF-54
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reaction rate is optimal at detergent:protein ratio of 1:6
Triton X-100
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reaction rate is optimal at detergent:protein ratio of 1:6
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0.09
neolactotetraosylceramide
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0.33 - 2.5
UDP-N-acetyl-D-glucosamine
0.33
UDP-N-acetyl-D-glucosamine
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solubilized enzyme
2.5
UDP-N-acetyl-D-glucosamine
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membrane-bound enzyme
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additional information
pI: 8.7
additional information
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pI: 8.7
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beta3GnT7
SwissProt
brenda
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very weak expression of beta3GnT7
brenda
very weak expression of beta3GnT7
brenda
beta3GnT7 is most strongly expressed in the placenta and colon
brenda
breast cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness
brenda
very weak expression of beta3GnT7
brenda
moderate expression of beta3GnT7
brenda
KLN205-MUC1, lung cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness
brenda
moderate expression of beta3GnT7
brenda
beta3GnT7 is most strongly expressed in the placenta at the later stages of gestation and in colon
brenda
moderate expression of beta3GnT7
brenda
moderate expression of beta3GnT7
brenda
very weak expression of beta3GnT7
brenda
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lymphoma cell line
brenda
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brenda
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B3GN7_MOUSE
397
0
45379
Swiss-Prot
other Location (Reliability: 3 )
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45000
x * 45000, calculated from the amino acid sequence
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?
x * 45000, calculated from the amino acid sequence
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cDNA from placenta encoding beta3GnT7 is cloned and partially characterized, open reading frame encodes a 397-amino acids protein
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medicine
enzyme may be used as diagnostic marker of human cancer or as target molecule for the development of a new therapy
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Kataoka, K.; Huh, N.h.
A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro
Biochem. Biophys. Res. Commun.
294
843-848
2002
Homo sapiens (Q8NFL0), Homo sapiens, Mus musculus (Q8K0J2), Mus musculus, Mus musculus beta3GnT7 (Q8K0J2)
brenda
Basu, M.; Basu, S.
Biosynthesis in vitro of Ii core glycosphingolipids from neolactotetraosylceramide by beta1-3- and beta1-6-N-acetylglucosaminyltransferases from mouse T-lymphoma
J. Biol. Chem.
259
12557-12562
1984
Mus musculus
brenda
Biellmann, F.; Henion, T.R.; Burki, K.; Hennet, T.
Impaired sexual behavior in male mice deficient for the beta 1-3 N-acetylglucosaminyltransferase-I gene
Mol. Reprod. Dev.
75
699-706
2008
Mus musculus
brenda