BRENDA - Enzyme Database show
show all sequences of 2.4.1.149

A novel beta1,3-N-acetylglucosaminyltransferase involved in invasion of cancer cells as assayed in vitro

Kataoka, K.; Huh, N.h.; Biochem. Biophys. Res. Commun. 294, 843-848 (2002)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
enzyme may be used as diagnostic marker of human cancer or as target molecule for the development of a new therapy
Mus musculus
Cloned(Commentary)
Commentary
Organism
cDNA from placenta encoding beta3GnT7 is cloned and partially characterized, open reading frame encodes a 397-amino acids protein
Mus musculus
human ortholog to mouse enzyme beta3GnT7 has the chromosomal locus 2q37.1
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
45000
-
x * 45000, calculated from the amino acid sequence
Mus musculus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
?
-
-
-
additional information
Mus musculus beta3GnT7
beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q8NFL0
-
-
Mus musculus
Q8K0J2
beta3GnT7
-
Mus musculus beta3GnT7
Q8K0J2
beta3GnT7
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
cerebellum
very weak expression of beta3GnT7
Mus musculus
-
cerebrum
very weak expression of beta3GnT7
Mus musculus
-
colon
beta3GnT7 is most strongly expressed in the placenta and colon
Mus musculus
-
FM3A cell
breast cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness
Mus musculus
-
heart
very weak expression of beta3GnT7
Mus musculus
-
kidney
moderate expression of beta3GnT7
Mus musculus
-
KLN205 cell
KLN205-MUC1, lung cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness
Mus musculus
-
lung
moderate expression of beta3GnT7
Mus musculus
-
placenta
beta3GnT7 is most strongly expressed in the placenta at the later stages of gestation and in colon
Mus musculus
-
small intestine
moderate expression of beta3GnT7
Mus musculus
-
stomach
moderate expression of beta3GnT7
Mus musculus
-
testis
very weak expression of beta3GnT7
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
638581
Mus musculus
?
-
-
-
-
additional information
beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
638581
Mus musculus beta3GnT7
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 45000, calculated from the amino acid sequence
Mus musculus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
additional information
-
pI: 8.7
Mus musculus
Application (protein specific)
Application
Commentary
Organism
medicine
enzyme may be used as diagnostic marker of human cancer or as target molecule for the development of a new therapy
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
cDNA from placenta encoding beta3GnT7 is cloned and partially characterized, open reading frame encodes a 397-amino acids protein
Mus musculus
human ortholog to mouse enzyme beta3GnT7 has the chromosomal locus 2q37.1
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
45000
-
x * 45000, calculated from the amino acid sequence
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
additional information
Mus musculus
beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
?
-
-
-
additional information
Mus musculus beta3GnT7
beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
?
-
-
-
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
cerebellum
very weak expression of beta3GnT7
Mus musculus
-
cerebrum
very weak expression of beta3GnT7
Mus musculus
-
colon
beta3GnT7 is most strongly expressed in the placenta and colon
Mus musculus
-
FM3A cell
breast cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness
Mus musculus
-
heart
very weak expression of beta3GnT7
Mus musculus
-
kidney
moderate expression of beta3GnT7
Mus musculus
-
KLN205 cell
KLN205-MUC1, lung cancer cell line, higher expression of beta3GnT7 in cancer cell lines with low degrees of invasiveness
Mus musculus
-
lung
moderate expression of beta3GnT7
Mus musculus
-
placenta
beta3GnT7 is most strongly expressed in the placenta at the later stages of gestation and in colon
Mus musculus
-
small intestine
moderate expression of beta3GnT7
Mus musculus
-
stomach
moderate expression of beta3GnT7
Mus musculus
-
testis
very weak expression of beta3GnT7
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
638581
Mus musculus
?
-
-
-
-
additional information
beta3GnT7 may play a role in preventing cells from migrating out of the original tissues and invading surrounding tissues
638581
Mus musculus beta3GnT7
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 45000, calculated from the amino acid sequence
Mus musculus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
additional information
-
pI: 8.7
Mus musculus
Other publictions for EC 2.4.1.149
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
722360
Peng
Helicobacter pylori beta1,3-N- ...
Helicobacter pylori
Glycobiology
22
1453-1464
2012
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4
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1
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19
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4
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19
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703900
Lee
Association of beta-1,3-N-acet ...
Homo sapiens
Glycobiology
19
655-664
2009
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-
-
-
-
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1
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1
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1
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1
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2
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706504
Bao
Tumor suppressor function of l ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
106
12109-12114
2009
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1
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7
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1
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7
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1
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-
-
-
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-
2
1
1
2
-
-
689093
Biellmann
Impaired sexual behavior in ma ...
Mus musculus
Mol. Reprod. Dev.
75
699-706
2008
-
-
-
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-
-
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1
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2
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1
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-
-
658728
Seko
beta1,3-N-Acetylglucosaminyltr ...
Homo sapiens
FEBS Lett.
556
216-220
2004
-
-
1
-
-
-
1
1
-
3
-
1
-
1
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-
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5
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1
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1
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1
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1
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1
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3
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1
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5
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1
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1
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-
638581
Kataoka
A novel beta1,3-N-acetylglucos ...
Homo sapiens, Mus musculus, Mus musculus beta3GnT7
Biochem. Biophys. Res. Commun.
294
843-848
2002
-
1
2
-
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-
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1
2
-
5
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12
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2
1
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1
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1
2
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1
2
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12
-
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2
1
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1
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-
-
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638583
Salo
Several polylactosamine-modify ...
Homo sapiens
Glycobiology
12
217-228
2002
-
-
-
-
-
-
-
-
-
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1
-
1
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1
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6
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1
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1
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6
-
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-
-
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638580
Fukuzumi
Comparison of the expression o ...
Rattus norvegicus
Glycobiology
11
481-494
2001
-
-
-
-
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-
1
3
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1
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2
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2
1
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2
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1
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1
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3
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1
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2
1
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2
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1
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638579
McAuliffe
Synthesis of selectively radio ...
Homo sapiens
Glycoconjugate J.
16
767-772
1999
-
-
1
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-
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1
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2
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1
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4
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1
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1
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1
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2
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4
-
1
-
-
-
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638582
Sasaki
Expression cloning of cDNA enc ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
94
14294-14299
1997
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-
1
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2
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1
2
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1
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1
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5
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6
1
1
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1
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1
2
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1
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5
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6
1
1
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638584
Hummel
Elongation of N-acetyllactosam ...
Cricetulus griseus
Eur. J. Biochem.
245
428-433
1997
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638578
Kawashima
Purification and characterizat ...
Bos taurus
J. Biol. Chem.
268
27118-27126
1993
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6
3
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3
2
5
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1
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1
1
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1
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10
1
2
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8
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1
1
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6
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3
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3
2
5
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1
1
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1
1
1
10
1
2
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8
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1
1
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638576
Holmes
Characterization of a beta 1-- ...
Homo sapiens
Arch. Biochem. Biophys.
260
461-468
1988
6
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1
3
1
1
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1
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1
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6
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1
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6
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1
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1
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6
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1
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2
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638577
van den Eijnden
Biosynthesis of blood group i- ...
Rattus norvegicus
J. Biol. Chem.
263
12461-12471
1988
-
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6
5
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2
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2
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1
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1
1
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1
1
10
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1
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1
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6
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5
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2
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2
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1
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1
1
10
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1
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1
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638575
Hosomi
Human serum contains N-acetyll ...
Homo sapiens
J. Biochem.
95
1655-1659
1984
2
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1
2
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1
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638606
Basu
Biosynthesis in vitro of Ii co ...
Mus musculus
J. Biol. Chem.
259
12557-12562
1984
4
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489473
Van den Eijnden
Novikoff ascites tumor cells c ...
Rattus norvegicus
J. Biol. Chem.
258
3435-3437
1983
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3
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638561
Zielenski
The occurrence of two novel N- ...
Homo sapiens
FEBS Lett.
158
164-168
1983
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