Reference on EC 2.3.1.301 - mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sachdeva, S.; Musayev, F.; Alhamadsheh, M.; Neel Scarsdale, J.; Tonie Wright, H.; Reynolds, K.
Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates
Bioorg. Chem.
36
85-90
2008
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis ATCC 25618 (P9WNG3)
Alhamadsheh, M.; Waters, N.; Sachdeva, S.; Lee, P.; Reynolds, K.
Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors
Bioorg. Med. Chem. Lett.
18
6402-6405
2008
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis H37Rv (P9WNG3)
Alhamadsheh, M.; Musayev, F.; Komissarov, A.; Sachdeva, S.; Wright, H.; Scarsdale, N.; Florova, G.; Reynolds, K.
Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes
Chem. Biol.
14
513-524
2007
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis H37Rv (P9WNG3)
Sachdeva, S.; Musayev, F.; Alhamadsheh, M.; Scarsdale, J.; Wright, H.; Reynolds, K.
Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH
Chem. Biol.
15
402-412
2008
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis ATCC 25618 (P9WNG3)
Zhang, X.; Yu, H.; Zhong, W.; Wang, L.; Li, S.
Structure-based design, synthesis of novel inhibitors of Mycobacterium tuberculosis FabH as potential anti-tuberculosis agents
Chin. Chem. Lett.
20
1019-1022
2009
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis ATCC 25618 (P9WNG3)
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Choi, K.; Kremer, L.; Besra, G.; Rock, C.
Identification and substrate specificity of beta-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis
J. Biol. Chem.
275
28201-28207
2000
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis H37Rv (P9WNG3)
Scarsdale, J.; Kazanina, G.; He, X.; Reynolds, K.; Wright, H.
Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III
J. Biol. Chem.
276
20516-20522
2001
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis H37Rv (P9WNG3)
Brown, A.; Sridharan, S.; Kremer, L.; Lindenberg, S.; Dover, L.; Sacchettini, J.; Besra, G.
Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH Factors influencing catalysis and substrate specificity
J. Biol. Chem.
280
32539-32547
2005
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis H37Rv (P9WNG3)
Veyron-Churlet, R.; Molle, V.; Taylor, R.; Brown, A.; Besra, G.; Zanella-Cleon, I.; Fuetterer, K.; Kremer, L.
The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residue
J. Biol. Chem.
284
6414-6424
2009
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis H37Rv (P9WNG3)
Musayev, F.; Sachdeva, S.; Scarsdale, J.; Reynolds, K.; Wright, H.
Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A
J. Mol. Biol.
346
1313-1321
2005
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis ATCC 25618 (P9WNG3)
Sachdeva, S.; Reynolds, K.
Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase III (mtFabH) assay principles and method
Methods Mol. Med.
142
205-213
2008
Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis ATCC 25618 (P9WNG3)
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