Literature summary for 2.3.1.301 extracted from

Alhamadsheh, M.; Musayev, F.; Komissarov, A.; Sachdeva, S.; Wright, H.; Scarsdale, N.; Florova, G.; Reynolds, K.
Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes (2007), Chem. Biol., 14, 513-524 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
enzyme in complex with inhibitor CoA methyldisulfide	Mycobacterium tuberculosis

Inhibitors

Inhibitors	Comment	Organism	Structure
CoA decyldisulfide	-	Mycobacterium tuberculosis
CoA octyldisulfide	-	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WNG3	-	-
Mycobacterium tuberculosis H37Rv	P9WNG3	-	-

Synonyms

Synonyms	Comment	Organism
FabH	-	Mycobacterium tuberculosis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0012	-	pH 7.4, 23°C	Mycobacterium tuberculosis	CoA decyldisulfide
0.0301	-	pH 7.4, 23°C	Mycobacterium tuberculosis	CoA octyldisulfide

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Release 2023.1 (January 2023)