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Literature summary for 2.3.1.301 extracted from
- Identification and substrate specificity of beta-ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis (2000), J. Biol. Chem., 275, 28201-28207 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | not inhibitory: cerulenin | Mycobacterium tuberculosis | |
| thiolactomycin | - |
Mycobacterium tuberculosis |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| decanoyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | - |
3-oxolauroyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| decanoyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis H37Rv | - |
3-oxolauroyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| lauroyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | - |
3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| lauroyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis H37Rv | - |
3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| additional information | Mycobacterium tuberculosis | FabH clearly prefers long-chain acyl-CoA substrates rather than acyl-ACP primers and does not utilize acetyl-CoA as a primer. No substrates: acetyl-CoA, butyryl-CoA, or isovaleryl-CoA | ? | - |
- |
|
| additional information | Mycobacterium tuberculosis H37Rv | FabH clearly prefers long-chain acyl-CoA substrates rather than acyl-ACP primers and does not utilize acetyl-CoA as a primer. No substrates: acetyl-CoA, butyryl-CoA, or isovaleryl-CoA | ? | - |
- |
|
| myristoyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | - |
3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| myristoyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis H37Rv | - |
3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| octanoyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | - |
3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| octanoyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis H37Rv | - |
3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| palmitoyl-CoA + malonyl-[acyl-carrier protein] | Mycobacterium tuberculosis | - |
3-oxostearoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WNG3 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WNG3 | - |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0013 | - |
substrate palmitoyl-CoA, pH 7., 37°C | Mycobacterium tuberculosis |
| 0.0134 | - |
substrate octanoyl-CoA, pH 7., 37°C | Mycobacterium tuberculosis |
| 0.0269 | - |
substrate decanoyl-CoA, pH 7., 37°C | Mycobacterium tuberculosis |
| 0.0569 | - |
substrate myristoyl-CoA, pH 7., 37°C | Mycobacterium tuberculosis |
| 0.13 | - |
substrate lauroyl-CoA, pH 7., 37°C | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| decanoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| decanoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis H37Rv | 3-oxolauroyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| lauroyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| lauroyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis H37Rv | 3-oxomyristoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| additional information | FabH clearly prefers long-chain acyl-CoA substrates rather than acyl-ACP primers and does not utilize acetyl-CoA as a primer. No substrates: acetyl-CoA, butyryl-CoA, or isovaleryl-CoA | Mycobacterium tuberculosis | ? | - |
- |
|
| additional information | FabH clearly prefers long-chain acyl-CoA substrates rather than acyl-ACP primers and does not utilize acetyl-CoA as a primer. No substrates: acetyl-CoA, butyryl-CoA, or isovaleryl-CoA | Mycobacterium tuberculosis H37Rv | ? | - |
- |
|
| myristoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| myristoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis H37Rv | 3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| octanoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| octanoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis H37Rv | 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
| palmitoyl-CoA + malonyl-[acyl-carrier protein] | - |
Mycobacterium tuberculosis | 3-oxostearoyl-[acyl-carrier protein] + CoA + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| FabH | - |
Mycobacterium tuberculosis |
| Rv0533c | - |
Mycobacterium tuberculosis |
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