Literature summary for 2.3.1.301 extracted from

Scarsdale, J.; Kazanina, G.; He, X.; Reynolds, K.; Wright, H.
Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (2001), J. Biol. Chem., 276, 20516-20522 .

Search for more literature for 2.3.1.301

Cloned(Commentary)

Cloned (Comment)	Organism
-	Mycobacterium tuberculosis

Crystallization (Commentary)

Crystallization (Comment)	Organism
strucure to 2.1 A resolution. A CoA/malonyl-ACP-binding channel leads from the enzyme surface to the buried active-site cysteine residue, and a second hydrophobic channel leads from the active site. In the ecFabH structure, this channel is blocked by a phenylalanine residue, whereas in Microbacterium tuberculosisFabH, this residue is a threonine, which permits binding of longer acyl chains	Mycobacterium tuberculosis

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
76600	-	gel filtration	Mycobacterium tuberculosis

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	P9WNG3	-	-
Mycobacterium tuberculosis H37Rv	P9WNG3	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	enzyme catalyzes a Claisen-type condensation between long chain acyl-CoA substrates such as myristoyl-CoA (C14) and malonyl-ACP. No substrates: acetyl-CoA, butanoyl-CoA	Mycobacterium tuberculosis	?	-	-
additional information	enzyme catalyzes a Claisen-type condensation between long chain acyl-CoA substrates such as myristoyl-CoA (C14) and malonyl-ACP. No substrates: acetyl-CoA, butanoyl-CoA	Mycobacterium tuberculosis H37Rv	?	-	-
myristoyl-CoA + a malonyl-[acyl-carrier protein]	-	Mycobacterium tuberculosis	3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2	-	?
myristoyl-CoA + a malonyl-[acyl-carrier protein]	-	Mycobacterium tuberculosis H37Rv	3-oxopalmitoyl-[acyl-carrier protein] + CoA + CO2	-	?

Subunits

Subunits	Comment	Organism
dimer	2 * 37000, SDS-PAGE	Mycobacterium tuberculosis

Synonyms

Synonyms	Comment	Organism
FabH	-	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)