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Information on EC 2.1.1.372 - [histone H4]-lysine20 N-trimethyltransferase and Organism(s) Schizosaccharomyces pombe and UniProt Accession Q9USK2

for references in articles please use BRENDA:EC2.1.1.372
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IUBMB Comments
The enzyme, characterized from the fission yeast Schizosaccharomyces pombe, catalyses three successive methylations of the L-lysine-20 residue of histone H4 (H4K20), forming the trimethylated form. The methylation of this site is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response. cf. EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase, and EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase.
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Schizosaccharomyces pombe
UNIPROT: Q9USK2
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The taxonomic range for the selected organisms is: Schizosaccharomyces pombe
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
NSD3, SET9, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SET9
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:[histone H4]-L-lysine20 N6-trimethyltransferase
The enzyme, characterized from the fission yeast Schizosaccharomyces pombe, catalyses three successive methylations of the L-lysine-20 residue of histone H4 (H4K20), forming the trimethylated form. The methylation of this site is apparently not involved in the regulation of gene expression or heterochromatin function but participates in DNA damage response. cf. EC 2.1.1.361, [histone H4]-lysine20 N-methyltransferase, and EC 2.1.1.362, [histone H4]-N-methyl-L-lysine20 N-methyltransferase.
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
adenosyl-L-methionine + [histone H4]-N6,N6-dimethyl-L-lysine20
adenosyl-L-homocysteine + [histone H4]-N6,N6,N6-trimethyl-L-lysine20
show the reaction diagram
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?
S-adenosyl-L-methionine + [histone H4]-L-lysine20
S-adenosyl-L-homocysteine + [histone H4]-N6-methyl-L-lysine20
show the reaction diagram
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?
S-adenosyl-L-methionine + [histone H4]-N6-methyl-L-lysine20
S-adenosyl-L-homocysteine + [histone H4]-N6,N6-dimethyl-L-lysine20
show the reaction diagram
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?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
Set9 is responsible for histone H4K20 methylation in Schizosaccharomyces pombe. H4K20 methylation does not have any apparent role in the regulation of gene expression or heterochromatin function but the modification has a role in DNA damage response. Loss of Set9 activity or mutation of H4K20 markedly impairs cell survival after genotoxic challenge and compromises the ability of cells to maintain checkpoint mediated cell cycle arrest
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Sanders, S.L.; Portoso, M.; Mata, J.; Bahler, J.; Allshire, R.C.; Kouzarides, T.
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage
Cell
119
603-614
2004
Schizosaccharomyces pombe (Q9USK2), Schizosaccharomyces pombe 972 (Q9USK2)
Manually annotated by BRENDA team