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Literature summary for 2.1.1.372 extracted from

  • Sanders, S.L.; Portoso, M.; Mata, J.; Bahler, J.; Allshire, R.C.; Kouzarides, T.
    Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage (2004), Cell, 119, 603-614 .
    View publication on PubMed
Search for more literature for 2.1.1.372

Organism

Organism UniProt Comment Textmining
Schizosaccharomyces pombe Q9USK2
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Schizosaccharomyces pombe 972 Q9USK2
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosyl-L-methionine + [histone H4]-N6,N6-dimethyl-L-lysine20
-
 Schizosaccharomyces pombe adenosyl-L-homocysteine + [histone H4]-N6,N6,N6-trimethyl-L-lysine20
-
 ?
adenosyl-L-methionine + [histone H4]-N6,N6-dimethyl-L-lysine20
-
 Schizosaccharomyces pombe 972 adenosyl-L-homocysteine + [histone H4]-N6,N6,N6-trimethyl-L-lysine20
-
 ?
S-adenosyl-L-methionine + [histone H4]-L-lysine20
-
 Schizosaccharomyces pombe S-adenosyl-L-homocysteine + [histone H4]-N6-methyl-L-lysine20
-
 ?
S-adenosyl-L-methionine + [histone H4]-L-lysine20
-
 Schizosaccharomyces pombe 972 S-adenosyl-L-homocysteine + [histone H4]-N6-methyl-L-lysine20
-
 ?
S-adenosyl-L-methionine + [histone H4]-N6-methyl-L-lysine20
-
 Schizosaccharomyces pombe S-adenosyl-L-homocysteine + [histone H4]-N6,N6-dimethyl-L-lysine20
-
 ?
S-adenosyl-L-methionine + [histone H4]-N6-methyl-L-lysine20
-
 Schizosaccharomyces pombe 972 S-adenosyl-L-homocysteine + [histone H4]-N6,N6-dimethyl-L-lysine20
-
 ?

Synonyms

Synonyms Comment Organism
SET9
-
 Schizosaccharomyces pombe

General Information

General Information Comment Organism
physiological function Set9 is responsible for histone H4K20 methylation in Schizosaccharomyces pombe. H4K20 methylation does not have any apparent role in the regulation of gene expression or heterochromatin function but the modification has a role in DNA damage response. Loss of Set9 activity or mutation of H4K20 markedly impairs cell survival after genotoxic challenge and compromises the ability of cells to maintain checkpoint mediated cell cycle arrest Schizosaccharomyces pombe