Information on EC 2.1.1.369 - [histone H3]-lysine27 N-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.369 [histone H3]-lysine27 N-methyltransferase
IUBMB Comments
This entry describes enzymes that methylate the L-lysine-27 residue of histone H3 only once, generating a monomethylated form. This modification influences the binding of chromatin-associated proteins. The methylation of lysine-27 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.371, [histone H3]-lysine27 N-dimethyltransferase, and EC 2.1.1.356, [histone H3]-lysine27 N-trimethyltransferase.
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Word Map
  • 2.1.1.369
  • chromatin
  • heterochromatic
  • monomethylation
  • monomethyltransferases
  • re-replication
  • set-domain
  • euchromatic
  • pericentromeric
  • histone-modifying
  • overreplication
  • suvar3-9
  • replication-dependent
  • lysine-27
  • sliding
The enzyme appears in viruses and cellular organisms
Synonyms
Arabidopsis trithorax-related protein 5, ARABIDOPSIS TRITHORAX-RELATED PROTEIN5, ARABIDOPSIS TRITHORAX-RELATED PROTEIN6, ATXR5, Atxr6, SET15, SET34, Tetrahymena Trithorax related protein 1, trithorax-related protein 5, trithorax-related protein 6, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a [histone H3]-L-lysine27 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine27
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
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