Literature summary for 2.1.1.369 extracted from

Zhao, X.; Wang, Y.; Wang, Y.; Liu, Y.; Gao, S.
Histone methyltransferase TXR1 is required for both H3 and H3.3 lysine 27 methylation in the well-known ciliated protist Tetrahymena thermophila (2017), Sci. China Life Sci., 60, 264-270 .

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Organism

Organism	UniProt	Comment	Textmining
Tetrahymena thermophila	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	K27Q mutation in variant H3.3 further aggravates the replication stress phenotype of K27Q mutation in canonical H3. H3.3 is a physiologically relevant substrate of TXR1	Tetrahymena thermophila	?	-	-
S-adenosyl-L-methionine + [histone H3.3]-L-lysine27	-	Tetrahymena thermophila	S-adenosyl-L-homocysteine + [histone H3.3]-N6-methyl-L-lysine27	-	?
S-adenosyl-L-methionine + [histone H3]-L-lysine27	-	Tetrahymena thermophila	S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine27	-	?

Synonyms

Synonyms	Comment	Organism
Tetrahymena Trithorax related protein 1	-	Tetrahymena thermophila
TXR1	-	Tetrahymena thermophila

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Release 2023.1 (January 2023)