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Information on EC 2.1.1.368 - [histone H3]-lysine9 N-dimethyltransferase

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IUBMB Comments
This entry describes several enzymes, characterized from plants, that successively methylate the L-lysine-9 residue of histone H3 (H3K9) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. In general, the methylation of H3K9 leads to transcriptional repression of the affected target genes. cf. EC 2.1.1.367, [histone H3]-lysine9 N-methyltransferase, EC 2.1.1.366, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase, and EC 2.1.1.355, [histone H3]-lysine9 N-trimethyltransferase.
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Word Map
  • 2.1.1.368
  • suvar3-9
  • chromatin
  • rna-directed
  • heterochromatinization
  • monomethylated
  • methyltransferases
  • heterochromatic
  • chromatin-remodeling
  • transposable
  • trimethylation
  • redundantly
  • dnaj
  • microrchidia
  • dosage-dependent
  • chromocenter
  • hmtases
  • heterochromatin-specific
The enzyme appears in viruses and cellular organisms
Synonyms
EHMT1, EHMT2, G9a, GLP, H3 lysine-9 specific histone-lysine N-methyltransferase, KMT1C, KMT1D, SDG32, SET1, SET13, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = 2 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
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overall reaction
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S-adenosyl-L-methionine + a [histone H3]-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine9
show the reaction diagram
(1a)
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S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine9 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine9
show the reaction diagram
(1b)
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PATHWAY SOURCE
PATHWAYS
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