Any feedback?
Please rate this page
(search_result.php)
(0/150)

BRENDA support

Refine search

Search General Information

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 8 of 8
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.368physiological function deletion of the catalytic domain of either histone methyltransferases EHMT2 or SETDB1 in growing oocytes leads to significant reduction of global H3K9me2 or H3K9me3 levels, respectively, in the maternal pronucleus. The asymmetry of global 5?methylcytosine (5mC) oxidation is significantly reduced in the zygotes that carry maternal mutation of either the Ehmt2 or Setdb1 genes. The levels of 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine increase, and 5mC levels decrease in the mutant maternal pronuclei. H3K9me3-rich rings around the nucleolar-like bodies retain 5mC in the maternal mutant zygotes. The maternal pronuclei expand in size in the mutant zygotes and contain a significantly increased number of nucleolar-like bodies compared with normal zygotes 760074
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.368physiological function ectopic expression of SET1 causes an increase in methylated histone H3 lysine 9 and abnormal chromosome segregation in tobacco suspension cells, and inhibits tobacco plant growth. The inhibition of plant growth is caused by reduced cell expansion as well as by abnormal cell division and differentiation. Deletion of the C-terminally located catalytic domain of the protein abolishes the ectopic effects of SET1 on plant growth 757977
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.368physiological function ectopic expression of SET1 increases the amount of dimethylated H3K9 and induces chromosome-segregation defects in tobacco BY2 cells. The histone methyltransferase activity, the association with specific chromatin regions and with condensed chromosomes, and the cellular effects largely depend on the C-terminal region including the SET domain of the protein. The N-terminal part of SET1 is capable of targeting the green fluorescent protein to interphase chromatin. SET1 binds LHP1, the Arabidopsis homolog of animal heterochromatin protein 1, and LHP1 colocalizes with heterochromatin containing high amounts of dimethylated H3K9 758007
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.368physiological function histone H3K9 methyltransferases G9a/KMT1C, GLP/KMT1D, SETDB1/KMT1E, and Suv39h1/KMT1A, coexist in the same megacomplex. In Suv39h or G9a null cells, the remaining histone H3K9 methyltransferases are destabilized at the protein level, indicating. The four enzymes are recruited to major satellite repeats, a known Suv39h1 genomic target, but also to multiple G9a target genes. The four H3K9 histone H3K9 methyltransferases display a functional cooperation in the regulation of known G9a target genes 759762
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.368physiological function in SUVH2 null plants, mono- and dimethyl H3K9, mono- and dimethyl H3K27, and monomethyl H4K20 are significantly reduced. Loss of function suppresses, whereas overexpression enhances, gene silencing, causes ectopic heterochromatization and significant growth defects. Modification of transgene silencing by SUVH2 is partially transmitted to the offspring plants. This epigenetic stability correlates with heritable changes in DNA methylation. Mutational dissection of SUVH2 indicates an implication of its N-terminus and YDG domain in directing DNA methylation to target sequences. Gene silencing by SUVH2 depends on MET1 and DDM1, but not CMT3 756587
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.368physiological function SET1 methylates both K9 and K27 of histone H3 in vitro. Ectopic expression of SET1 increases the amount of dimethylated H3K9 and induces chromosome-segregation defects in tobacco BY2 cells. The histone methyltransferase activity, the association with specific chromatin regions and with condensed chromosomes, and the cellular effects largely depend on the C-terminal region including the SET domain of the protein. The N-terminal part of SET1 is capable of targeting the green fluorescent protein to interphase chromatin. SET1 binds LHP1, the Arabidopsis homolog of animal heterochromatin protein 1, and LHP1 colocalizes with heterochromatin containing high amounts of dimethylated H3K9 758007
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.368physiological function SUVH1 acts as an anti-silencing factor and promotes the expression of several endogenous genes with promoter DNA methylation. SUVH1 mutation does not alter DNA methylation levels, thus, SUVH1 functions downstream of DNA methylation. Histone H3 lysine 4 trimethylation is reduced in a SUVH1 mutant, in contrast, H3K9 methylation levels remain unchanged 759861
Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.368physiological function SUVH1 binds methylated DNA in vitro, is associated with euchromatic methylation in vivo, and forms a complex with two DNAJ domain-containing homologs, DNAJ1 and DNAJ2. Ectopic recruitment of DNAJ1 enhances gene transcription 760195
Results 1 - 8 of 8