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Literature summary for 2.1.1.368 extracted from

  • Naumann, K.; Fischer, A.; Hofmann, I.; Krauss, V.; Phalke, S.; Irmler, K.; Hause, G.; Aurich, A.C.; Dorn, R.; Jenuwein, T.; Reuter, G.
    Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis (2005), EMBO J., 24, 1418-1429 .
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
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 Arabidopsis thaliana 5634
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Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana O22781 isoform SuvH2
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Synonyms

Synonyms Comment Organism
SuvH2
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 Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function in SUVH2 null plants, mono- and dimethyl H3K9, mono- and dimethyl H3K27, and monomethyl H4K20 are significantly reduced. Loss of function suppresses, whereas overexpression enhances, gene silencing, causes ectopic heterochromatization and significant growth defects. Modification of transgene silencing by SUVH2 is partially transmitted to the offspring plants. This epigenetic stability correlates with heritable changes in DNA methylation. Mutational dissection of SUVH2 indicates an implication of its N-terminus and YDG domain in directing DNA methylation to target sequences. Gene silencing by SUVH2 depends on MET1 and DDM1, but not CMT3 Arabidopsis thaliana