Reference on EC 1.6.2.4 - NADPH-hemoprotein reductase and Organism(s) Rattus norvegicus and UniProt Accession P00388
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Kurzban, G.P.; Howarth, J.; Palmer, G.; Strobel, H.W.
NADPH-cytochrome P-450 reductase. Physical properties and redox behavior in the absence of the FAD moiety
J. Biol. Chem.
265
12272-12279
1990
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Vibet, A.; Dintinger, T.; Maboundou, J.C.; Gaillard, J.L.; Divoux, D.; Silberzahn, P.
Estrogen synthetase in the horse. Comparison of equine placental and rat liver NADPH-cytrochrome c (P-450) reductase activities
FEBS Lett.
261
31-34
1990
Equus caballus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Benveniste, I.; Lesot, A.; Hasenfratz, M.; Durst, F.
Immunochemical characterization of NADPH-cytochrome P-450 reductase from Jerusalem artichoke and other higher plants
Biochem. J.
259
847-853
1989
Saccharomyces cerevisiae, Helianthus tuberosus, Embryophyta, Locusta migratoria migratorioides, Rattus norvegicus, Sus scrofa
Ardies, C.M.; Lasker, J.M.; Bloswick, B.P.; Lieber, C.S.
Purification of NADPH:cytochrome c (cytochrome P-450) reductase from hamster liver microsomes by detergent extraction and affinity chromatography
Anal. Biochem.
162
39-46
1987
Mesocricetus auratus, Rattus norvegicus
Takahashi, N.; Saito, T.; Goda, Y.; Tomita, K.
Characterization of microsomal NADPH-dependent aldehyde reductase from rat brain
J. Biochem.
99
513-519
1986
Rattus norvegicus, Rattus norvegicus Wistar
Shephard, E.A.; Pike, S.F.; Rabin, B.R.; Phillips, I.R.
A rapid one-step purification of NADPH-cytochrome c (P-450) reductase from rat liver microsomes
Anal. Biochem.
129
430-433
1983
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Crankshaw, D.L.; Hetnarski, K.; Wilkinson, C.F.
Purification and characterization of NADPH--cytochrome c reductase from the midgut of the southern armyworm (Spodoptera eridania)
Biochem. J.
181
593-605
1979
Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Spodoptera eridania
Zimmermann, J.J.; Kasper, C.B.
Immunological and biochemical characterization of nuclear envelope reduced nicotinamide adenine dinucleotide phosphate-cytochrome c oxidoreductase
Arch. Biochem. Biophys.
190
726-735
1978
Rattus norvegicus
Yasukochi, Y.; Masters, B.S.S.
Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography
J. Biol. Chem.
251
5337-5344
1976
Rattus norvegicus, Sus scrofa
Masters, B.S.S.; Prough, R.A.; Kamin, H.
Properties of the stable aerobic and anaerobic half-reduced states of NADPH-cytochrome c reductase
Biochemistry
14
607-613
1975
Rattus norvegicus, Sus scrofa
Teschke, R.; Hasumura, Y.; Lieber, C.S.
Hepatic microsomal ethanol-oxidizing system: solubilization, isolation, and characterization
Arch. Biochem. Biophys.
163
404-415
1974
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Betz, G.; Roper, M.; Tsai, P.
Steroid 17,20-lyase from testis microsomes: participation of NADPH cytochrome c reductase
Arch. Biochem. Biophys.
163
318-323
1974
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Golf, S.W.; Graef, V.; Staudinger, H.
Solubilization and purification of the NADPH-cytochrome reductase from rat liver microsomes
Hoppe-Seyler's Z. Physiol. Chem.
355
1063-1069
1974
Rattus norvegicus, Rattus norvegicus Wistar
Omura, T.; Takesue, S.
A new method for simultaneous purification of cytochrome b5 and NADPH-cytochrome c reductase from rat liver microsomes
J. Biochem.
67
249-257
1970
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Cooper, M.B.; Craft, J.A.; Estall, M.R.; Rabin, B.R.
Asymmetric distribution of cytochrome P-450 and NADPH-cytochrome P-450 (cytochrome c) reductase in vesicles from smooth endoplasmic reticulum of rat liver
Biochem. J.
190
737-746
1980
Rattus norvegicus
Yasukochi, Y.; Masters, B.S.S.
Tetramer-dimer dissociation in homoglobin and the Bohr effect
J. Biol. Chem.
251
5537-5544
1976
Rattus norvegicus
Erecinska, M.
Cytochrome c Interaction with membranes, formylated cytochrome c1
Arch. Biochem. Biophys.
169
199-208
1975
Rattus norvegicus
Dialameh, G.H.
Isolation and partial purification of cytochrome-P-450 from induced rat liver
Biochem. Biophys. Res. Commun.
81
19-23
1978
Rattus norvegicus
Hara, T.; Taniguchi, M.
Relationship between changes in properties and contents of riboflavin derivatives of NADPH-cytochrome P-450 reductase in the liver microsomes of riboflavin-deficient rats
J. Biochem.
97
473-482
1985
Rattus norvegicus, Rattus norvegicus Wistar
Gut, J.; Kawato, S.; Cherry, R.J.; Winterhalter, K.H.; Richter, C.
Lipid peroxidation decreases the rotational mobility of cytochrome P-450 in rat liver microsomes
Biochim. Biophys. Acta
817
217-228
1985
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Lindeskog, P.; Haaparanta, T.; Norgard, M.; Glaumann, H.; Hansson, T.; Gustafsson J.
Isolation of rat intestinal microsomes: Partial characterisation of mucosal cytochrome P-450
Arch. Biochem. Biophys.
244
492-501
1986
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Balvers, W.G.; Boersma, M.G.; Vervoort, J.; Ouwehand, A.; Rietjens, I.M.C.M.
A specific interaction between NADPH-cytochrome reductase and phosphatidylserine and phosphatidylinositol
Eur. J. Biochem.
218
1021-1029
1993
Rattus norvegicus, Rattus norvegicus Wistar
McGuire, J.J.; Anderson, D.J.; McDonald, B.J.; Narayanasami, R.; Bennett, B.M.
Inhibition of NADPH-Cytochrome P450 Reductase and Glyceryl Trinitrate Biotransformation by Diphenyleneiodonium Sulfate
Biochem. Pharmacol.
56
881-893
1998
Rattus norvegicus, Rattus norvegicus Sprague-Dawley
Shen, A.L.; Porter, T.D.; Wilson, T.E.; Kasper, C.B.
Structural analysis of the FMN binding domain of NADPH-cytochrome P-450 oxidoreductase by site-directed mutagenesis
J. Biol. Chem.
264
7584-7589
1989
Rattus norvegicus
Shen, A.L.; Kasper, C.B.
Differential contributions of NADPH-Cytochrome P450 oxidoreductase FAD binding site residues to flavin binding and catalysis
J. Biol. Chem.
275
41087-41091
2000
Rattus norvegicus (P00388)
Kutty, R.K.; Maines, M.D.
Characterization of an NADH-dependent haem-degrading system in ox heart mitochondria
Biochem. J.
246
467-474
1987
Rattus norvegicus
Vatsis, K.P.; Coon, M.J.
Oxidative aldehyde deformylation catalyzed by NADPH-cytochrome P450 reductase and the flavoprotein domain of neuronal nitric oxide synthase
Biochem. Biophys. Res. Commun.
337
1107-1111
2005
Rattus norvegicus
Bonina, T.A.; Gilep, A.A.; Estabrook, R.W.; Usanov, S.A.
Engineering of proteolytically stable NADPH-cytochrome P450 reductase
Biochemistry
70
357-365
2005
Rattus norvegicus
Higashimoto, Y.; Sato, H.; Sakamoto, H.; Takahashi, K.; Palmer, G.; Noguchi, M.
The reactions of heme- and verdoheme-heme oxygenase-1 complexes with FMN-depleted NADPH-cytochrome P450 reductase. Electrons required for verdoheme oxidation can be transferred through a pathway not involving FMN
J. Biol. Chem.
281
31659-31667
2006
Rattus norvegicus
Yim, S.K.; Jung, H.C.; Pan, J.G.; Kang, H.S.; Ahn, T.; Yun, C.H.
Functional expression of mammalian NADPH-cytochrome P450 oxidoreductase on the cell surface of Escherichia coli
Protein Expr. Purif.
49
292-298
2006
Rattus norvegicus
Higashimoto, Y.; Sugishima, M.; Sato, H.; Sakamoto, H.; Fukuyama, K.; Palmer, G.; Noguchi, M.
Mass spectrometric identification of lysine residues of heme oxygenase-1 that are involved in its interaction with NADPH-cytochrome P450 reductase
Biochem. Biophys. Res. Commun.
367
852-858
2008
Rattus norvegicus (P00388)
Huber, W.J.; Backes, W.L.
Expression and characterization of full-length human heme oxygenase-1: the presence of intact membrane-binding region leads to increased binding affinity for NADPH cytochrome P450 reductase
Biochemistry
46
12212-12219
2007
Rattus norvegicus
Cherala, G.; Shapiro, B.H.; Dmello, A.P.
Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat
Drug Metab. Dispos.
35
1057-1063
2007
Rattus norvegicus
Yao, H.T.; Chang, Y.W.; Lan, S.J.; Yeh, T.K.
The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes
Food Chem. Toxicol.
46
645-653
2008
Homo sapiens, Rattus norvegicus
Wang, Y.; Gray, J.P.; Mishin, V.; Heck, D.E.; Laskin, D.L.; Laskin, J.D.
Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity
Free Radic. Biol. Med.
44
1169-1179
2008
Rattus norvegicus
Yim, S.K.; Jung, H.C.; Yun, C.H.; Pan, J.G.
Functional expression in Bacillus subtilis of mammalian NADPH-cytochrome P450 oxidoreductase and its spore-display
Protein Expr. Purif.
63
5-11
2008
Rattus norvegicus
Mast, N.; Liao, W.L.; Pikuleva, I.A.; Turko, I.V.
Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase
Arch. Biochem. Biophys.
483
81-89
2009
Rattus norvegicus (P00388)
Hall, C.N.; Keynes, R.G.; Garthwaite, J.
Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain
Biochem. J.
419
411-418
2009
Rattus norvegicus
Huber III, W.J.; Scruggs, B.A.; Backes, W.L.
C-Terminal membrane spanning region of human heme oxygenase-1 mediates a time-dependent complex formation with cytochrome P450 reductase
Biochemistry
48
190-197
2009
Rattus norvegicus
Kim, D.H.; Yim, S.K.; Kim, K.H.; Ahn, T.; Yun, C.H.
Continuous spectrofluorometric and spectrophotometric assays for NADPH-cytochrome P450 reductase activity using 5-cyano-2,3-ditolyl tetrazolium chloride
Biotechnol. Lett.
31
271-275
2009
Rattus norvegicus
Hamdane, D.; Xia, C.; Im, S.C.; Zhang, H.; Kim, J.J.; Waskell, L.
Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450
J. Biol. Chem.
284
11374-11384
2009
Rattus norvegicus (P00388)
Guengerich, F.P.; Martin, M.V.; Sohl, C.D.; Cheng, Q.
Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase
Nat. Protoc.
4
1245-1251
2009
Rattus norvegicus
Inaoka, Y.; Yazawa, T.; Mizutani, T.; Kokame, K.; Kangawa, K.; Uesaka, M.; Umezawa, A.; Miyamoto, K.
Regulation of P450 oxidoreductase by gonadotropins in rat ovary and its effect on estrogen production
Reprod. Biol. Endocrinol.
6
62
2008
Rattus norvegicus (P00388), Homo sapiens (P16435), Homo sapiens
Grinkova, Y.V.; Denisov, I.G.; Sligar, S.G.
Functional reconstitution of monomeric CYP3A4 with multiple cytochrome P450 reductase molecules in Nanodiscs
Biochem. Biophys. Res. Commun.
398
194-198
2010
Rattus norvegicus
Jang, H.H.; Jamakhandi, A.P.; Sullivan, S.Z.; Yun, C.H.; Hollenberg, P.F.; Miller, G.P.
Beta sheet 2-alpha helix C loop of cytochrome P450 reductase serves as a docking site for redox partners
Biochim. Biophys. Acta
1804
1285-1293
2010
Rattus norvegicus
Laursen, T.; Jensen, K.; Moller, B.L.
Conformational changes of the NADPH-dependent cytochrome P450 reductase in the course of electron transfer to cytochromes P450
Biochim. Biophys. Acta
1814
132-138
2011
Rattus norvegicus
Flueck, C.E.; Mullis, P.E.; Pandey, A.V.
Modeling of human P450 oxidoreductase structure by in silico mutagenesis and MD simulation
Mol. Cell. Endocrinol.
313
17-22
2009
Rattus norvegicus (P00388), Homo sapiens (P16435), Homo sapiens
Gray, J.P.; Mishin, V.; Heck, D.E.; Laskin, D.L.; Laskin, J.D.
Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species
Toxicol. Appl. Pharmacol.
247
76-82
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Iyanagi, T.; Xia, C.; Kim, J.J.
NADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family
Arch. Biochem. Biophys.
528
72-89
2012
Homo sapiens, Rattus norvegicus
Kenaan, C.; Zhang, H.; Shea, E.V.; Hollenberg, P.F.
Uncovering the role of hydrophobic residues in cytochrome P450-cytochrome P450 reductase interactions
Biochemistry
50
3957-3967
2011
Rattus norvegicus
Xia, C.; Hamdane, D.; Shen, A.L.; Choi, V.; Kasper, C.B.; Pearl, N.M.; Zhang, H.; Im, S.C.; Waskell, L.; Kim, J.J.
Conformational changes of NADPH-cytochrome P450 oxidoreductase are essential for catalysis and cofactor binding
J. Biol. Chem.
286
16246-16260
2011
Rattus norvegicus (P00388)
Shinkai, Y.; Nishihara, Y.; Amamiya, M.; Wakayama, T.; Li, S.; Kikuchi, T.; Nakai, Y.; Shimojo, N.; Kumagai, Y.
NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals
Free Radic. Biol. Med.
91
178-187
2016
Rattus norvegicus
Huang, R.; Zhang, M.; Rwere, F.; Waskell, L.; Ramamoorthy, A.
Kinetic and structural characterization of the interaction between the FMN binding domain of cytochrome P450 reductase and cytochrome c
J. Biol. Chem.
290
4843-4855
2015
Rattus norvegicus
Dai, Y.; Zhen, J.; Zhang, X.; Zhong, Y.; Liu, S.; Sun, Z.; Guo, Y.; Wu, Q.
Analysis of the complex formation, interaction and electron transfer pathway between the open conformation of NADPH-cytochrome P450 reductase and aromatase
Steroids
101
116-124
2015
Rattus norvegicus (P00388)
Nemeikaite-Ceniene, A.; Sarlauskas, J.; Miseviciene, L.; Maroziene, A.; Jonusiene, V.; Lesanavicius, M.; Cenas, N.
Aerobic cytotoxicity of aromatic N-oxides the role of NAD(P)H quinone oxidoreductase (NQO1)
Int. J. Mol. Sci.
21
8754
2020
Rattus norvegicus (P00388)
