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Literature summary for 1.6.2.4 extracted from

  • Shinkai, Y.; Nishihara, Y.; Amamiya, M.; Wakayama, T.; Li, S.; Kikuchi, T.; Nakai, Y.; Shimojo, N.; Kumagai, Y.
    NADPH-cytochrome P450 reductase-mediated denitration reaction of 2,4,6-trinitrotoluene to yield nitrite in mammals (2016), Free Radic. Biol. Med., 91, 178-187 .
    View publication on PubMed
Search for more literature for 1.6.2.4

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Rattus norvegicus
-
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-Sephadex gel filtration and 2',5'-ADP Sepharose 4B column chromatography Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information 2,4,6-trinitrophenol, 2,4-dinitrophenol, 2,6-dinitrotoluene, 1,2-dinitrobenzene, 1,4-dinitrobenzene, 2,4-dinitrobenzoic acid, 3,5-dinitrobenzoic acid, 2-nitrotoluene, 2-nitrobenzonitrile, 4-nitrotoluene and 4-nitrobenzaldehyde are not subject to denitration by the enzyme Rattus norvegicus ?
-
 ?
NADPH + H+ + 2,4,6-trinitrotoluene
-
 Rattus norvegicus NADP+ + nitrite + ?
-
 ?
NADPH + H+ + 4-nitroso-2,6-dinitrotoluene
-
 Rattus norvegicus NADP+ + 4-hydroxyamino-2,6-dinitrotoluene
-
 ?

Synonyms

Synonyms Comment Organism
NADPH-cytochrome P450 reductase
-
 Rattus norvegicus
P450R
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Rattus norvegicus
FMN
-
 Rattus norvegicus