Reference on EC 1.17.4.1 - ribonucleoside-diphosphate reductase and Organism(s) Homo sapiens and UniProt Accession P31350
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Elford, H.L.; Van't Riet, B.; Wampler, G.L.; Lin, A.L.; Elford, R.M.
Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents
Adv. Enzyme Regul.
19
151-168
1981
Homo sapiens
Lammers, M.; Follmann, H.
The ribonucleotide reductases - a unique group of metalloenzymes essential for cell proliferation
Struct. Bonding
54
27-91
1983
Tequatrovirus T4, Tequintavirus T5, Enterobacteria phage T6, Bos taurus, Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Mesocricetus auratus, Mus musculus, Rattus norvegicus, Tetradesmus obliquus
-
Holmgren, A.
Regulation of ribonucleotide reductase
Curr. Top. Cell. Regul.
19
47-76
1981
Escherichia phage T2, Tequatrovirus T4, Tequintavirus T5, Enterobacteria phage T6, Bos taurus, Oryctolagus cuniculus, Escherichia coli, Homo sapiens, Rattus norvegicus
Young, P.; Leeds, J.M.; Slabaugh, M.B.; Mathews, C.K.
Ribonucleotide reductase: evidence for specific association with HeLa cell mitochondria
Biochem. Biophys. Res. Commun.
203
46-52
1994
Homo sapiens
Schroeder, P.; Voevodskaya, N.; Klotz, L.O.; Brenneisen, P.; Graslund, A.; Sies, H.
Loss of the tyrosyl radical in mouse ribonucleotide reductase by (-)-epicatechin
Biochem. Biophys. Res. Commun.
326
614-617
2005
Homo sapiens, Mus musculus
Shao, J.; Zhou, B.; Zhu, L.; Bilio, A.J.; Su, L.; Yuan, Y.C.; Ren, S.; Lien, E.J.; Shih, J.; Yen, Y.
Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay
Biochem. Pharmacol.
69
627-634
2005
Homo sapiens
Qiu, W.; Zhou, B.; Darwish, D.; Shao, J.; Yen, Y.
Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits
Biochem. Biophys. Res. Commun.
340
428-434
2006
Homo sapiens (Q7LG56)
Gautam, A.; Bepler, G.
Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase
Cancer Res.
66
6497-6502
2006
Mus musculus, Homo sapiens (P23921)
Avolio, T.M.; Lee, Y.; Feng, N.; Xiong, K.; Jin, H.; Wang, M.; Vassilakos, A.; Wright, J.; Young, A.
RNA interference targeting the R2 subunit of ribonucleotide reductase inhibits growth of tumor cells in vitro and in vivo
Anticancer Drugs
18
377-388
2007
Homo sapiens
Sigmond, J.; Kamphuis, J.A.; Laan, A.C.; Hoebe, E.K.; Bergman, A.M.; Peters, G.J.
The synergistic interaction of gemcitabine and cytosine arabinoside with the ribonucleotide reductase inhibitor triapine is schedule dependent
Biochem. Pharmacol.
73
1548-1557
2007
Homo sapiens
Odenike, O.M.; Larson, R.A.; Gajria, D.; Dolan, M.E.; Delaney, S.M.; Karrison, T.G.; Ratain, M.J.; Stock, W.
Phase I study of the ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde-thiosemicarbazone (3-AP) in combination with high dose cytarabine in patients with advanced myeloid leukemia
Invest. New Drugs
26
233-239
2008
Homo sapiens
Kowol, C.R.; Berger, R.; Eichinger, R.; Roller, A.; Jakupec, M.A.; Schmidt, P.P.; Arion, V.B.; Keppler, B.K.
Gallium(III) and iron(III) complexes of alpha-N-heterocyclic thiosemicarbazones: synthesis, characterization, cytotoxicity, and interaction with ribonucleotide reductase
J. Med. Chem.
50
1254-1265
2007
Homo sapiens, Mus musculus
Cappellacci, L.; Franchetti, P.; Vita, P.; Petrelli, R.; Lavecchia, A.; Jayaram, H.N.; Saiko, P.; Graser, G.; Szekeres, T.; Grifantini, M.
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3-C-methyladenosine derivatives
J. Med. Chem.
51
4260-4269
2008
Homo sapiens
Karp, J.E.; Giles, F.J.; Gojo, I.; Morris, L.; Greer, J.; Johnson, B.; Thein, M.; Sznol, M.; Low, J.
A phase I study of the novel ribonucleotide reductase inhibitor 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine) in combination with the nucleoside analog fludarabine for patients with refractory acute leukemias and aggressive myeloprol
Leuk. Res.
32
71-77
2008
Homo sapiens
Zhu, L.; Zhou, B.; Chen, X.; Jiang, H.; Shao, J.; Yen, Y.
Inhibitory mechanisms of heterocyclic carboxaldehyde thiosemicabazones for two forms of human ribonucleotide reductase
Biochem. Pharmacol.
78
1178-1185
2009
Homo sapiens
Smith, P.; Zhou, B.; Ho, N.; Yuan, Y.C.; Su, L.; Tsai, S.C.; Yen, Y.
2.6 a X-ray crystal structure of human p53R2, a p53-inducible ribonucleotide reductase
Biochemistry
48
11134-11141
2009
Homo sapiens
Krishnan, K.; Prathiba, K.; Jayaprakash, V.; Basu, A.; Mishra, N.; Zhou, B.; Hu, S.; Yen, Y.
Synthesis and ribonucleotide reductase inhibitory activity of thiosemicarbazones
Bioorg. Med. Chem. Lett.
18
6248-6250
2008
Homo sapiens
Holmgren, A.; Sengupta, R.
The use of thiols by ribonucleotide reductase
Free Radic. Biol. Med.
49
1617-1628
2010
Saccharomyces cerevisiae, Escherichia coli, Homo sapiens, Lactobacillus leichmannii, Mus musculus
Fairman, J.W.; Wijerathna, S.R.; Ahmad, M.F.; Xu, H.; Nakano, R.; Jha, S.; Prendergast, J.; Welin, R.M.; Flodin, S.; Roos, A.; Nordlund, P.; Li, Z.; Walz, T.; Dealwis, C.G.
Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization
Nat. Struct. Mol. Biol.
18
316-322
2011
Homo sapiens
Aye, Y.; Stubbe, J.
Clofarabine 5-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit
Proc. Natl. Acad. Sci. USA
108
9815-9820
2011
Homo sapiens
Saiko, P.; Graser, G.; Giessrigl, B.; Lackner, A.; Grusch, M.; Krupitza, G.; Basu, A.; Sinha, B.; Jayaprakash, V.; Jaeger, W.; Fritzer-Szekeres, M.; Szekeres, T.
A novel N-hydroxy-N-aminoguanidine derivative inhibits ribonucleotide reductase activity: Effects in human HL-60 promyelocytic leukemia cells and synergism with arabinofuranosylcytosine (Ara-C)
Biochem. Pharmacol.
81
50-59
2011
Homo sapiens
Chen, X.; Xu, Z.; Zhang, L.; Liu, H.; Liu, X.; Lou, M.; Zhu, L.; Huang, B.; Yang, C.G.; Zhu, W.; Shao, J.
The conserved Lys-95 charged residue cluster is critical for the homodimerization and enzyme activity of human ribonucleotide reductase small subunit m2
J. Biol. Chem.
289
909-920
2014
Homo sapiens (P31350)
Yu, Y.; Suryo Rahmanto, Y.; Hawkins, C.L.; Richardson, D.R.
The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity
Mol. Pharmacol.
79
921-931
2011
Homo sapiens
Pontarin, G.; Ferraro, P.; Bee, L.; Reichard, P.; Bianchi, V.
Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells
Proc. Natl. Acad. Sci. USA
109
13302-13307
2012
Homo sapiens (Q7LG56)
Knappenberger, A.J.; Ahmad, M.F.; Viswanathan, R.; Dealwis, C.G.; Harris, M.E.
Nucleoside analogue triphosphates allosterically regulate human ribonucleotide reductase and identify chemical determinants that drive substrate specificity
Biochemistry
55
5884-5896
2016
Saccharomyces cerevisiae, Homo sapiens (P23921), Homo sapiens (P23921 and P31350), Homo sapiens
Petrelli, R.; Meli, M.; Vita, P.; Torquati, I.; Ferro, A.; Vodnala, M.; DAlessandro, N.; Tolomeo, M.; Del Bello, F.; Kusumanchi, P.; Franchetti, P.; Grifantini, M.; Jayaram, H.N.; Hofer, A.; Cappellacci, L.
From the covalent linkage of drugs to novel inhibitors of ribonucleotide reductase synthesis and biological evaluation of valproic esters of 3-C-methyladenosine
Bioorg. Med. Chem. Lett.
24
5304-5309
2014
Homo sapiens (P23921)
Graser-Loescher, G.; Schoenhuber, A.; Ciglenec, C.; Eberl, S.; Krupitza, G.; Mader, R.M.; Jadav, S.S.; Jayaprakash, V.; Fritzer-Szekeres, M.; Szekeres, T.; Saiko, P.
Thiosemicarbazone derivatives, thiazolyl hydrazones, effectively inhibit leukemic tumor cell growth Down-regulation of ribonucleotide reductase activity and synergism with arabinofuranosylcytosine
Food Chem. Toxicol.
108
53-62
2017
Homo sapiens (P23921)
Lee, B.; Ha, S.Y.; Song, D.H.; Lee, H.W.; Cho, S.Y.; Park, C.K.
High expression of ribonucleotide reductase subunit M2 correlates with poor prognosis of hepatocellular carcinoma
Gut and liver
8
662-668
2014
Homo sapiens (P31350)
Foskolou, I.P.; Jorgensen, C.; Leszczynska, K.B.; Olcina, M.M.; Tarhonskaya, H.; Haisma, B.; DAngiolella, V.; Myers, W.K.; Domene, C.; Flashman, E.; Hammond, E.M.
Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication
Mol. Cell
66
206-220.e9
2017
Homo sapiens (Q7LG56)
