BRENDA - Enzyme Database
show all sequences of 1.17.4.1

The ribonucleotide reductases - a unique group of metalloenzymes essential for cell proliferation

Lammers, M.; Follmann, H.; Struct. Bonding 54, 27-91 (1983)
No PubMed abstract available

Data extracted from this reference:

Activating Compound
Activating Compound
Commentary
Organism
Structure
ATP
stimulation of CDP reduction
Mesocricetus auratus
ATP
-
Mus musculus
ATP
-
Saccharomyces cerevisiae
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Bos taurus
ATP
-
Enterobacteria phage T6
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia virus T4
ATP
-
Escherichia virus T5
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Homo sapiens
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Oryctolagus cuniculus
ATP
stimulation of CDP reduction
Rattus norvegicus
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia coli
ATP
stimulation of CDP reduction
Tetradesmus obliquus
dCTP
stimulation of UDP reduction
Bos taurus
dCTP
stimulation of UDP reduction
Escherichia coli
dCTP
stimulation of UDP reduction
Escherichia virus T4
dCTP
stimulation of UDP reduction
Homo sapiens
dCTP
-
Mesocricetus auratus
dCTP
stimulation of UDP reduction
Mus musculus
dCTP
stimulation of UDP reduction
Oryctolagus cuniculus
dCTP
stimulation of UDP reduction
Rattus norvegicus
dCTP
stimulation of UDP reduction
Saccharomyces cerevisiae
dCTP
stimulation of UDP reduction
Tetradesmus obliquus
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Bos taurus
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Escherichia coli
dGTP
stimulation of tubercidin diphosphate reduction
Escherichia virus T4
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Homo sapiens
dGTP
-
Mesocricetus auratus
dGTP
stimulation of tubercidin diphosphate reduction
Mus musculus
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Oryctolagus cuniculus
dGTP
stimulation of tubercidin diphosphate reduction
Rattus norvegicus
dGTP
stimulation of tubercidin diphosphate reduction
Saccharomyces cerevisiae
dGTP
stimulation of tubercidin diphosphate reduction
Tetradesmus obliquus
dGTP
-
Enterobacteria phage T6
dGTP
-
Escherichia virus T5
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Bos taurus
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Escherichia coli
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Escherichia virus T4
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Homo sapiens
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Mus musculus
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Oryctolagus cuniculus
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Rattus norvegicus
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Saccharomyces cerevisiae
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Tetradesmus obliquus
dTTP
-
Enterobacteria phage T6
dTTP
-
Escherichia virus T5
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Bos taurus
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Escherichia coli
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Escherichia virus T4
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Homo sapiens
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Mus musculus
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Oryctolagus cuniculus
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Rattus norvegicus
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Saccharomyces cerevisiae
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Tetradesmus obliquus
Inhibitors
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
-
Bos taurus
1,10-phenanthroline
-
Escherichia coli
1,10-phenanthroline
-
Escherichia virus T4
1,10-phenanthroline
-
Homo sapiens
1,10-phenanthroline
-
Mus musculus
1,10-phenanthroline
-
Oryctolagus cuniculus
1,10-phenanthroline
-
Rattus norvegicus
1,10-phenanthroline
-
Saccharomyces cerevisiae
1,10-phenanthroline
-
Tetradesmus obliquus
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole
-
Mus musculus
2-Nitro-imidazole
trivial name azomycin
Escherichia coli
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Bos taurus
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Homo sapiens
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Mesocricetus auratus
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Mus musculus
3-Methyl-4-nitrophenol
-
Mesocricetus auratus
4-Amino-2-phenylimidazole-5-carboxamide
-
Rattus norvegicus
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Escherichia coli
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Mus musculus
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
5-(1-Aziridinyl)-2,4-dinitrobenzamide
-
Homo sapiens
5-(1-Aziridinyl)-2,4-dinitrobenzamide
-
Rattus norvegicus
8-hydroxyquinoline
-
Escherichia coli
8-hydroxyquinoline
-
Oryctolagus cuniculus
8-hydroxyquinoline
-
Rattus norvegicus
8-hydroxyquinoline 5-sulfonate
-
Escherichia coli
8-hydroxyquinoline 5-sulfonate
-
Oryctolagus cuniculus
8-hydroxyquinoline 5-sulfonate
-
Rattus norvegicus
Acetohydroxamic acid
-
Escherichia coli
aurintricarboxylate
oligomeric form
Escherichia coli
aurintricarboxylate
oligomeric form
Saccharomyces cerevisiae
aurintricarboxylate
oligomeric form
Tetradesmus obliquus
bathophenanthroline disulfonate
-
Bos taurus
bathophenanthroline disulfonate
-
Mus musculus
bathophenanthroline disulfonate
-
Oryctolagus cuniculus
Catechol derivatives
-
Rattus norvegicus
Cibacron blue F3 GA
-
Mus musculus
desferrioxamine
-
Homo sapiens
EDTA
-
Mesocricetus auratus
EDTA
-
Mus musculus
EDTA
-
Tetradesmus obliquus
EDTA
-
Homo sapiens
EDTA
-
Rattus norvegicus
EDTA
-
Bos taurus
EDTA
-
Escherichia coli
ethyleneglycol-bis-(2-aminoethylether)-N,N,N',N'-tetraacetic acid
trivial name EGTA
Mus musculus
Fe2+
-
Rattus norvegicus
Fe2+
concentrations higher than 0.1-1 mM
Tetradesmus obliquus
glutathione
analogs with aromatic substituents
Mus musculus
Hydroxyurea
1 mM, complete inactivation of thymus enzyme
Bos taurus
Hydroxyurea
-
Mesocricetus auratus
Hydroxyurea
-
Saccharomyces cerevisiae
Hydroxyurea
-
Tetradesmus obliquus
Hydroxyurea
-
Mus musculus
Hydroxyurea
-
Escherichia virus T4
Hydroxyurea
-
Escherichia virus T5
Hydroxyurea
-
Rattus norvegicus
Hydroxyurea
-
Escherichia coli
Hydroxyurea
-
Oryctolagus cuniculus
Hydroxyurea
-
Homo sapiens
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Bos taurus
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Homo sapiens
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Mus musculus
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
meso-alpha,beta-Diphenylsuccinate
-
Mus musculus
Mn2+
concentrations higher than 0.1-1 mM
Tetradesmus obliquus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Bos taurus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Escherichia coli
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Escherichia virus T4
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Homo sapiens
additional information
-
Mesocricetus auratus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Mus musculus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Oryctolagus cuniculus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Rattus norvegicus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Saccharomyces cerevisiae
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Tetradesmus obliquus
n-Hexanohydroxamic acid
-
Escherichia coli
N-Methylhydroxylamine
-
Escherichia coli
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Escherichia coli
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Homo sapiens
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Mus musculus
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
pyridoxal 5'-phosphate/NaBH4
-
Mus musculus
Pyrogallol derivatives
-
Rattus norvegicus
Thenoyltrifluoroacetone
-
Mus musculus
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Iron
-
Bos taurus
Iron
subunit B2 contains iron, nonheme-like porphyrin complexes
Escherichia coli
Iron
-
Escherichia virus T4
Iron
-
Mus musculus
Iron
-
Oryctolagus cuniculus
Iron
-
Rattus norvegicus
Iron
-
Tetradesmus obliquus
Mg2+
2fold stimulation
Bos taurus
Mg2+
-
Escherichia virus T4
Mg2+
-
Mesocricetus auratus
Mg2+
-
Oryctolagus cuniculus
Mg2+
subunit B1 requires Mg2+ ions in the 10 mM concentration range for activity
Escherichia coli
additional information
Mg2+ is not required for activity in vitro
Bos taurus
additional information
-
Mus musculus
additional information
Mg2+ is not required for activity in vitro
Rattus norvegicus
additional information
Mg2+ is not required for activity in vitro
Saccharomyces cerevisiae
additional information
Mg2+ is not required for activity in vitro
Tetradesmus obliquus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
39000
-
alpha, alpha,beta2, 2 * 80000 + 2 * 39000, SDS-PAGE
Escherichia coli
45000
-
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
55000
-
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
75000
-
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
75000
-
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
78000
-
alpha,alphabeta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
80000
-
alpha, alpha,beta2, 2 * 80000 + 2 * 39000, SDS-PAGE
Escherichia coli
82000
-
alpha,alphabeta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
84000
-
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
85000
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
90000
-
2 * 90000 + x * ?, Novikoff hepatoma cells
Escherichia coli
90000
-
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
100000
-
alpha,beta, 1 * 100000 + 1 * 100000, Molt F4 lymphoblast cells
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ribonucleoside diphosphate + reduced thioredoxin
Tetradesmus obliquus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Tetradesmus obliquus
?
ribonucleoside diphosphate + reduced thioredoxin
Mus musculus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Mus musculus
?
ribonucleoside diphosphate + reduced thioredoxin
Escherichia coli
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Escherichia coli
?
ribonucleoside diphosphate + reduced thioredoxin
Homo sapiens
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Homo sapiens
?
ribonucleoside diphosphate + reduced thioredoxin
Rattus norvegicus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Rattus norvegicus
?
ribonucleoside diphosphate + reduced thioredoxin
Saccharomyces cerevisiae
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Saccharomyces cerevisiae
?
ribonucleoside diphosphate + reduced thioredoxin
Bos taurus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Bos taurus
?
ribonucleoside diphosphate + reduced thioredoxin
Oryctolagus cuniculus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Oryctolagus cuniculus
?
ribonucleoside diphosphate + reduced thioredoxin
Escherichia virus T4
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Escherichia virus T4
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Bos taurus
-
-
-
Enterobacteria phage T6
-
-
-
Escherichia coli
-
-
-
Escherichia virus T4
-
-
-
Escherichia virus T5
-
-
-
Homo sapiens
-
Molt 4F cells
-
Mesocricetus auratus
-
-
-
Mus musculus
-
Ehrlich ascites tumor cells
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
Novikoff hepatoma cells
-
Saccharomyces cerevisiae
-
-
-
Tetradesmus obliquus
-
green algae
-
Reaction
Reaction
Commentary
Organism
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Bos taurus
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Escherichia virus T4
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Homo sapiens
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Mus musculus
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Oryctolagus cuniculus
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Rattus norvegicus
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Saccharomyces cerevisiae
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Tetradesmus obliquus
2'-deoxyribonucleoside 5'-diphosphate + thioredoxin disulfide + H2O = ribonucleoside 5'-diphosphate + thioredoxin
proposed mechanism
Escherichia coli
Source Tissue
Source Tissue
Commentary
Organism
Textmining
bone marrow
-
Oryctolagus cuniculus
-
Ehrlich ascites carcinoma cell
-
Mus musculus
-
liver
regenerating liver
Rattus norvegicus
-
lymphoblast
Molt 4F cells
Homo sapiens
-
Novikoff ascites tumor cell
-
Rattus norvegicus
-
thymus
calf
Bos taurus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,6-diaminopurineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxy-2,6-diaminopurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
2-aminopurineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxy-2-aminopurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
benzimidazoleriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxybenzimidazolriboside diphosphate + H2O
-
437918
Escherichia coli
?
purineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxypurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Tetradesmus obliquus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Tetradesmus obliquus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mus musculus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Homo sapiens
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Rattus norvegicus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Saccharomyces cerevisiae
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Saccharomyces cerevisiae
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Bos taurus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Oryctolagus cuniculus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Mesocricetus auratus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mesocricetus auratus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T4
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Enterobacteria phage T6
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Enterobacteria phage T6
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia virus T5
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T5
ir
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Tetradesmus obliquus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Tetradesmus obliquus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mus musculus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Homo sapiens
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Rattus norvegicus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Saccharomyces cerevisiae
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Saccharomyces cerevisiae
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Bos taurus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Oryctolagus cuniculus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T4
?
tubercidin diphosphate + reduced thioredoxin
14% of GDP reduction rate
437918
Escherichia coli
2'-deoxytubercidin diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
?
Subunits
Subunits
Commentary
Organism
?
-
Bos taurus
?
2 * 90000 + x * ?, Novikoff hepatoma cells
Escherichia coli
?
-
Rattus norvegicus
?
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
dimer
alpha,beta, 1 * 100000 + 1 * 100000, Molt F4 lymphoblast cells
Homo sapiens
hexamer
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
tetramer
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
tetramer
alpha, alpha',beta2, 2 * 80000 + 2 * 39000, SDS-PAGE; alpha,alpha'beta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
tetramer
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
Activating Compound (protein specific)
Activating Compound
Commentary
Organism
Structure
ATP
stimulation of CDP reduction
Mesocricetus auratus
ATP
-
Mus musculus
ATP
-
Saccharomyces cerevisiae
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Bos taurus
ATP
-
Enterobacteria phage T6
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia virus T4
ATP
-
Escherichia virus T5
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Homo sapiens
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Oryctolagus cuniculus
ATP
stimulation of CDP reduction
Rattus norvegicus
ATP
stimulation of CDP reduction; stimulation of UDP reduction
Escherichia coli
ATP
stimulation of CDP reduction
Tetradesmus obliquus
dCTP
stimulation of UDP reduction
Bos taurus
dCTP
stimulation of UDP reduction
Escherichia coli
dCTP
stimulation of UDP reduction
Escherichia virus T4
dCTP
stimulation of UDP reduction
Homo sapiens
dCTP
-
Mesocricetus auratus
dCTP
stimulation of UDP reduction
Mus musculus
dCTP
stimulation of UDP reduction
Oryctolagus cuniculus
dCTP
stimulation of UDP reduction
Rattus norvegicus
dCTP
stimulation of UDP reduction
Saccharomyces cerevisiae
dCTP
stimulation of UDP reduction
Tetradesmus obliquus
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Bos taurus
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Escherichia coli
dGTP
stimulation of tubercidin diphosphate reduction
Escherichia virus T4
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Homo sapiens
dGTP
-
Mesocricetus auratus
dGTP
stimulation of tubercidin diphosphate reduction
Mus musculus
dGTP
stimulation of ADP reduction; stimulation of tubercidin diphosphate reduction
Oryctolagus cuniculus
dGTP
stimulation of tubercidin diphosphate reduction
Rattus norvegicus
dGTP
stimulation of tubercidin diphosphate reduction
Saccharomyces cerevisiae
dGTP
stimulation of tubercidin diphosphate reduction
Tetradesmus obliquus
dGTP
-
Enterobacteria phage T6
dGTP
-
Escherichia virus T5
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Bos taurus
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Escherichia coli
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Escherichia virus T4
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Homo sapiens
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Mus musculus
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Oryctolagus cuniculus
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of GDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Rattus norvegicus
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Saccharomyces cerevisiae
dTTP
stimulation of 2,6-diaminopurine riboside reduction; stimulation of 2-aminopurineriboside diphosphate reduction; stimulation of benzimidazoleriboside diphosphate reduction; stimulation of CDP reduction; stimulation of purine riboside diphosphate reduction; stimulation of UDP reduction
Tetradesmus obliquus
dTTP
-
Enterobacteria phage T6
dTTP
-
Escherichia virus T5
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Bos taurus
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Escherichia coli
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Escherichia virus T4
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Homo sapiens
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Mus musculus
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Oryctolagus cuniculus
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Rattus norvegicus
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Saccharomyces cerevisiae
additional information
overview: stimulation of various enzymes; stimulation by effector nucleotides; stimulation with various substrates
Tetradesmus obliquus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
1,10-phenanthroline
-
Bos taurus
1,10-phenanthroline
-
Escherichia coli
1,10-phenanthroline
-
Escherichia virus T4
1,10-phenanthroline
-
Homo sapiens
1,10-phenanthroline
-
Mus musculus
1,10-phenanthroline
-
Oryctolagus cuniculus
1,10-phenanthroline
-
Rattus norvegicus
1,10-phenanthroline
-
Saccharomyces cerevisiae
1,10-phenanthroline
-
Tetradesmus obliquus
2,3-Dihydro-1H-pyrazolo[2,3-a]imidazole
-
Mus musculus
2-Nitro-imidazole
trivial name azomycin
Escherichia coli
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Bos taurus
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Homo sapiens
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Mesocricetus auratus
3,5-diamino-1H-1,2,4-triazole
trivial name guanazole
Mus musculus
3-Methyl-4-nitrophenol
-
Mesocricetus auratus
4-Amino-2-phenylimidazole-5-carboxamide
-
Rattus norvegicus
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Escherichia coli
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Mus musculus
4-Methyl-5-amino isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
5-(1-Aziridinyl)-2,4-dinitrobenzamide
-
Homo sapiens
5-(1-Aziridinyl)-2,4-dinitrobenzamide
-
Rattus norvegicus
8-hydroxyquinoline
-
Escherichia coli
8-hydroxyquinoline
-
Oryctolagus cuniculus
8-hydroxyquinoline
-
Rattus norvegicus
8-hydroxyquinoline 5-sulfonate
-
Escherichia coli
8-hydroxyquinoline 5-sulfonate
-
Oryctolagus cuniculus
8-hydroxyquinoline 5-sulfonate
-
Rattus norvegicus
Acetohydroxamic acid
-
Escherichia coli
aurintricarboxylate
oligomeric form
Escherichia coli
aurintricarboxylate
oligomeric form
Saccharomyces cerevisiae
aurintricarboxylate
oligomeric form
Tetradesmus obliquus
bathophenanthroline disulfonate
-
Bos taurus
bathophenanthroline disulfonate
-
Mus musculus
bathophenanthroline disulfonate
-
Oryctolagus cuniculus
Catechol derivatives
-
Rattus norvegicus
Cibacron blue F3 GA
-
Mus musculus
desferrioxamine
-
Homo sapiens
EDTA
-
Mesocricetus auratus
EDTA
-
Mus musculus
EDTA
-
Tetradesmus obliquus
EDTA
-
Homo sapiens
EDTA
-
Rattus norvegicus
EDTA
-
Bos taurus
EDTA
-
Escherichia coli
ethyleneglycol-bis-(2-aminoethylether)-N,N,N',N'-tetraacetic acid
trivial name EGTA
Mus musculus
Fe2+
-
Rattus norvegicus
Fe2+
concentrations higher than 0.1-1 mM
Tetradesmus obliquus
glutathione
analogs with aromatic substituents
Mus musculus
Hydroxyurea
1 mM, complete inactivation of thymus enzyme
Bos taurus
Hydroxyurea
-
Mesocricetus auratus
Hydroxyurea
-
Saccharomyces cerevisiae
Hydroxyurea
-
Tetradesmus obliquus
Hydroxyurea
-
Mus musculus
Hydroxyurea
-
Escherichia virus T4
Hydroxyurea
-
Escherichia virus T5
Hydroxyurea
-
Rattus norvegicus
Hydroxyurea
-
Escherichia coli
Hydroxyurea
-
Oryctolagus cuniculus
Hydroxyurea
-
Homo sapiens
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Bos taurus
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Homo sapiens
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Mus musculus
Isoquinoline-1-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
meso-alpha,beta-Diphenylsuccinate
-
Mus musculus
Mn2+
concentrations higher than 0.1-1 mM
Tetradesmus obliquus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Bos taurus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Escherichia coli
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Escherichia virus T4
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Homo sapiens
additional information
-
Mesocricetus auratus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Mus musculus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Oryctolagus cuniculus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Rattus norvegicus
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Saccharomyces cerevisiae
additional information
overview: naturally occuring inhibitors e.g. proteins and nucleotides
Tetradesmus obliquus
n-Hexanohydroxamic acid
-
Escherichia coli
N-Methylhydroxylamine
-
Escherichia coli
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Escherichia coli
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Homo sapiens
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Mus musculus
Pyridine-2-carboxaldehyde thiosemicarbazone
-
Rattus norvegicus
pyridoxal 5'-phosphate/NaBH4
-
Mus musculus
Pyrogallol derivatives
-
Rattus norvegicus
Thenoyltrifluoroacetone
-
Mus musculus
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Iron
-
Bos taurus
Iron
subunit B2 contains iron, nonheme-like porphyrin complexes
Escherichia coli
Iron
-
Escherichia virus T4
Iron
-
Mus musculus
Iron
-
Oryctolagus cuniculus
Iron
-
Rattus norvegicus
Iron
-
Tetradesmus obliquus
Mg2+
2fold stimulation
Bos taurus
Mg2+
-
Escherichia virus T4
Mg2+
-
Mesocricetus auratus
Mg2+
-
Oryctolagus cuniculus
Mg2+
subunit B1 requires Mg2+ ions in the 10 mM concentration range for activity
Escherichia coli
additional information
Mg2+ is not required for activity in vitro
Bos taurus
additional information
-
Mus musculus
additional information
Mg2+ is not required for activity in vitro
Rattus norvegicus
additional information
Mg2+ is not required for activity in vitro
Saccharomyces cerevisiae
additional information
Mg2+ is not required for activity in vitro
Tetradesmus obliquus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
35000
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
39000
-
alpha, alpha,beta2, 2 * 80000 + 2 * 39000, SDS-PAGE
Escherichia coli
45000
-
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
55000
-
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
75000
-
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
75000
-
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
78000
-
alpha,alphabeta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
80000
-
alpha, alpha,beta2, 2 * 80000 + 2 * 39000, SDS-PAGE
Escherichia coli
82000
-
alpha,alphabeta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
84000
-
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
85000
-
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
90000
-
2 * 90000 + x * ?, Novikoff hepatoma cells
Escherichia coli
90000
-
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
100000
-
alpha,beta, 1 * 100000 + 1 * 100000, Molt F4 lymphoblast cells
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ribonucleoside diphosphate + reduced thioredoxin
Tetradesmus obliquus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Tetradesmus obliquus
?
ribonucleoside diphosphate + reduced thioredoxin
Mus musculus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Mus musculus
?
ribonucleoside diphosphate + reduced thioredoxin
Escherichia coli
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Escherichia coli
?
ribonucleoside diphosphate + reduced thioredoxin
Homo sapiens
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Homo sapiens
?
ribonucleoside diphosphate + reduced thioredoxin
Rattus norvegicus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Rattus norvegicus
?
ribonucleoside diphosphate + reduced thioredoxin
Saccharomyces cerevisiae
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Saccharomyces cerevisiae
?
ribonucleoside diphosphate + reduced thioredoxin
Bos taurus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Bos taurus
?
ribonucleoside diphosphate + reduced thioredoxin
Oryctolagus cuniculus
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Oryctolagus cuniculus
?
ribonucleoside diphosphate + reduced thioredoxin
Escherichia virus T4
enzyme catalyzes the first unique step in DNA synthesis
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
Escherichia virus T4
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
bone marrow
-
Oryctolagus cuniculus
-
Ehrlich ascites carcinoma cell
-
Mus musculus
-
liver
regenerating liver
Rattus norvegicus
-
lymphoblast
Molt 4F cells
Homo sapiens
-
Novikoff ascites tumor cell
-
Rattus norvegicus
-
thymus
calf
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2,6-diaminopurineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxy-2,6-diaminopurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
2-aminopurineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxy-2-aminopurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
benzimidazoleriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxybenzimidazolriboside diphosphate + H2O
-
437918
Escherichia coli
?
purineriboside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxypurineriboside diphosphate + H2O
-
437918
Escherichia coli
?
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Tetradesmus obliquus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Tetradesmus obliquus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mus musculus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Homo sapiens
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Rattus norvegicus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Saccharomyces cerevisiae
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Saccharomyces cerevisiae
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Bos taurus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Oryctolagus cuniculus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Mesocricetus auratus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mesocricetus auratus
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T4
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Enterobacteria phage T6
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Enterobacteria phage T6
ir
ribonucleoside diphosphate + reduced thioredoxin
-
437918
Escherichia virus T5
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T5
ir
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Tetradesmus obliquus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Tetradesmus obliquus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Mus musculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Mus musculus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Escherichia coli
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Homo sapiens
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Homo sapiens
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Rattus norvegicus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Rattus norvegicus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Saccharomyces cerevisiae
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Saccharomyces cerevisiae
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Bos taurus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Bos taurus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Oryctolagus cuniculus
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Oryctolagus cuniculus
?
ribonucleoside diphosphate + reduced thioredoxin
enzyme catalyzes the first unique step in DNA synthesis
437918
Escherichia virus T4
2'-deoxyribonucleoside diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia virus T4
?
tubercidin diphosphate + reduced thioredoxin
14% of GDP reduction rate
437918
Escherichia coli
2'-deoxytubercidin diphosphate + oxidized thioredoxin + H2O
-
437918
Escherichia coli
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
-
Bos taurus
?
2 * 90000 + x * ?, Novikoff hepatoma cells
Escherichia coli
?
-
Rattus norvegicus
?
2 * 90000 + x * 75000, most likely 1 75000 Da subunit, SDS-PAGE
Tetradesmus obliquus
dimer
alpha,beta, 1 * 100000 + 1 * 100000, Molt F4 lymphoblast cells
Homo sapiens
hexamer
4 * 45000 + 1 * 45000 + 1 * 75000, regenerating liver
Rattus norvegicus
tetramer
2 * 84000 + 2 * 55000, SDS-PAGE
Bos taurus
tetramer
alpha, alpha',beta2, 2 * 80000 + 2 * 39000, SDS-PAGE; alpha,alpha'beta2, 2 * 82000 + 2 * 78000, each subunit composed of 2 polypeptide chains, subunit B1, 82000 Da, sedimentation equilibrium centrifugation, subunit B2, low speed sedimentation equilibrium centrifugation
Escherichia coli
tetramer
alpha2beta2, 2 * 85000 + 2 * 35000, enzyme induced in Escherichia coli after infection with bacteriophage T4, SDS-PAGE
Escherichia virus T4
Other publictions for EC 1.17.4.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
744958
Graser-Loescher
Thiosemicarbazone derivatives ...
Homo sapiens
Food Chem. Toxicol.
108
53-62
2017
-
2
-
-
-
-
-
-
-
-
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1
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1
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2
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1
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-
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-
-
-
-
-
-
-
-
1
1
1
1
-
-
744978
Alnajar
Ribonucleotide reductases fro ...
Bifidobacterium longum subsp. Longum, Bifidobacterium longum subsp. Longum ATCC 15707
Front. Microbiol.
8
1409
2017
-
-
-
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-
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2
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-
-
-
-
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1
1
-
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745680
Zhu
Manipulating the bacterial ce ...
Escherichia coli
mBio
8
e01741-17
2017
-
1
-
-
-
-
-
-
-
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
745759
Foskolou
Ribonucleotide reductase requ ...
Homo sapiens
Mol. Cell
66
206-220.e9
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
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1
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-
-
-
-
-
-
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-
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1
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
744357
Lofstad
Activation of the class Ib ri ...
Bacillus cereus, Bacillus cereus ATCC 14579
Biochemistry
55
4998-5001
2016
-
-
1
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
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1
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
744359
Knappenberger
Nucleoside analogue triphosph ...
Homo sapiens, Saccharomyces cerevisiae
Biochemistry
55
5884-5896
2016
8
-
2
-
1
-
-
-
-
-
-
-
-
4
-
-
2
-
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
-
-
12
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
11
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
744781
Zimanyi
Molecular basis for allosteri ...
Escherichia coli
eLife
5
e07141
2016
3
-
-
1
-
-
-
-
-
-
-
3
-
2
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
-
-
-
-
-
3
-
-
-
1
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
746517
Johansson
Structural mechanism of allos ...
Pseudomonas aeruginosa
Structure
24
906-917
2016
2
-
1
1
3
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
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-
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1
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-
-
-
-
-
-
-
-
-
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2
-
1
-
1
3
-
-
-
-
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1
-
-
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-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745325
Jonna
Diversity in overall activity ...
Pseudomonas aeruginosa
J. Biol. Chem.
290
17339-17348
2015
3
-
-
-
-
-
-
-
-
-
-
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3
-
-
-
-
-
-
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1
3
1
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-
-
1
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-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
3
1
-
-
-
1
-
-
-
-
1
1
-
-
-
727050
Parker
Bacillus subtilis class Ib rib ...
Bacillus subtilis, Bacillus subtilis JH624
Biochemistry
53
766-776
2014
2
-
-
-
-
-
1
-
-
2
3
-
-
3
-
-
1
-
-
-
6
-
8
1
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
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1
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-
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2
3
-
-
-
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1
-
-
6
-
8
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727994
Chen
The conserved Lys-95 charged r ...
Homo sapiens
J. Biol. Chem.
289
909-920
2014
-
-
1
-
2
-
-
-
-
-
-
-
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1
-
-
-
-
-
-
-
-
-
-
-
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-
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-
-
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1
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2
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-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
744504
Petrelli
From the covalent linkage of ...
Homo sapiens
Bioorg. Med. Chem. Lett.
24
5304-5309
2014
1
1
-
-
-
-
1
-
-
-
-
-
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1
-
-
-
-
-
1
-
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2
-
-
-
-
-
-
-
-
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1
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-
1
1
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-
-
-
-
-
1
1
-
-
-
-
-
-
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-
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1
-
-
2
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
745050
Lee
High expression of ribonucleo ...
Homo sapiens
Gut and liver
8
662-668
2014
-
1
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
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-
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-
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1
-
-
-
-
-
-
-
-
-
1
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-
-
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-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745156
Olshansky
Kinetics of hydrogen atom abs ...
Escherichia coli
J. Am. Chem. Soc.
136
16210-16216
2014
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
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1
1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
745317
Makhlynets
-
Streptococcus sanguinis class ...
Streptococcus sanguinis, Streptococcus sanguinis SK36
J. Biol. Chem.
289
6259-6272
2014
-
1
1
-
-
-
-
-
-
2
-
-
-
2
-
-
1
-
-
-
-
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2
-
1
-
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-
-
-
-
2
-
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-
-
1
1
2
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-
-
-
-
-
-
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2
-
-
-
-
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1
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
745385
Hammerstad
The class Ib ribonucleotide r ...
Mycobacterium tuberculosis
J. Biol. Inorg. Chem.
19
893-902
2014
-
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
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1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
746494
Arnaoutov
Enzyme regulation. IRBIT is a ...
Homo sapiens
Science
345
1512-1515
2014
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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-
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-
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-
-
-
-
-
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-
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1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727944
Chimploy
Ribonucleotide reductase assoc ...
Rattus norvegicus
J. Biol. Chem.
288
13145-13155
2013
-
-
-
-
-
-
-
-
2
-
-
-
-
1
-
-
-
-
-
1
-
-
1
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-
-
-
-
-
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-
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-
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-
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-
-
-
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-
-
-
-
2
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-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728298
Mazumder
Single-cell analysis of ribonu ...
Saccharomyces cerevisiae
Mol. Cell. Biol.
33
635-642
2013
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
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-
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-
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-
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-
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-
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-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
728151
Ahmad
Role of arginine 293 and gluta ...
Saccharomyces cerevisiae
J. Mol. Biol.
419
315-329
2012
-
-
1
1
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
6
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728677
Pontarin
Mammalian ribonucleotide reduc ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
109
13302-13307
2012
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
714233
Seyedsayamdost
Use of 2,3,5-F(3)Y-beta2 and 3 ...
Escherichia coli
Biochemistry
50
1403-1411
2011
1
-
-
-
-
-
-
1
-
1
-
1
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
-
2
1
-
-
-
-
1
1
-
-
-
1
1
-
-
-
714236
Cotruvo
Escherichia coli class Ib ribo ...
Escherichia coli, Escherichia coli GR536
Biochemistry
50
1672-1681
2011
-
-
-
-
-
-
-
-
-
2
-
-
-
2
-
-
1
-
-
-
-
-
-
-
1
-
-
-
1
-
-
3
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
714258
Zhang
Bacillus subtilis class Ib rib ...
Bacillus subtilis, Bacillus subtilis JH624
Biochemistry
50
5615-5623
2011
2
-
1
-
-
-
-
-
-
2
-
-
-
3
-
-
1
-
-
-
-
-
4
1
1
-
-
-
1
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
-
-
4
1
1
-
-
-
1
-
-
-
1
1
1
1
-
-
715170
Han
DFT calculations for intermedi ...
Escherichia coli
Inorg. Chem.
50
2302-2320
2011
-
-
-
-
-
-
-
-
-
3
-
-
-
3
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
716143
Sanchez-Romero
Organization of ribonucleoside ...
Escherichia coli, Escherichia coli K-12 CM735
Microbiology
157
2220-2225
2011
-
-
1
-
-
-
-
-
2
-
-
-
-
3
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
716317
Logan
Closing the circle on ribonucl ...
Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhimurium
Nat. Struct. Mol. Biol.
18
251-253
2011
3
-
-
1
-
-
3
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
6
9
-
-
-
-
-
-
-
2
-
-
-
3
-
-
2
1
-
-
-
3
-
-
-
-
-
3
-
-
-
-
-
-
-
-
6
9
-
-
-
-
-
-
-
-
-
3
3
-
-
-
716318
Fairman
Structural basis for allosteri ...
Homo sapiens
Nat. Struct. Mol. Biol.
18
316-322
2011
1
-
-
1
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
716792
Aye
Clofarabine 5-di and -triphosp ...
Homo sapiens
Proc. Natl. Acad. Sci. USA
108
9815-9820
2011
2
-
1
-
1
-
3
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
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-
-
2
-
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-
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-
-
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-
-
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2
-
-
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-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
726918
Saiko
A novel N-hydroxy-N-aminoguani ...
Homo sapiens
Biochem. Pharmacol.
81
50-59
2011
-
1
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
1
-
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-
-
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-
1
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-
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-
-
-
-
-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727344
Kan
Mutational analysis of splicin ...
Corynebacterium phage P1201
Curr. Microbiol.
62
1282-1286
2011
-
-
-
-
3
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
727885
Crona
NrdH-redoxin protein mediates ...
Bacillus anthracis, Bacillus anthracis ATCC 14579
J. Biol. Chem.
286
33053-33060
2011
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
728322
Martin
The alternative aerobic ribonu ...
Escherichia coli
Mol. Microbiol.
80
319-334
2011
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
728343
Yu
The potent and novel thiosemic ...
Homo sapiens
Mol. Pharmacol.
79
921-931
2011
-
1
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
728670
Ando
Structural interconversions mo ...
Escherichia coli
Proc. Natl. Acad. Sci. USA
108
21046-21051
2011
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
713645
Gurmu
Expression, purification, crys ...
Human gammaherpesvirus 8
Acta Crystallogr. Sect. F
66
734-737
2010
-
-
1
1
-
-
-
-
-
1
1
-
-
3
-
-
1
-
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
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-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
1
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
714184
Cotruvo
An active dimanganese(III)-tyr ...
Escherichia coli
Biochemistry
49
1297-1309
2010
2
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
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-
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-
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-
-
-
-
-
-
-
-
1
1
-
-
-
1
-
-
-
1
1
1
1
-
-
714196
Jiang
Two distinct mechanisms of ina ...
Chlamydia trachomatis
Biochemistry
49
5340-5349
2010
-
-
-
-
-
-
1
-
-
2
-
1
-
4
-
-
-
-
-
-
-
-
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-
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-
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-
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-
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-
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-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
714622
Sanchez-Romero
Correlation between ribonucleo ...
Escherichia coli
BMC Mol. Biol.
11
11
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
715085
Holmgren
The use of thiols by ribonucle ...
Escherichia coli, Homo sapiens, Lactobacillus leichmannii, Mus musculus, Saccharomyces cerevisiae
Free Radic. Biol. Med.
49
1617-1628
2010
-
-
-
-
-
-
20
-
-
8
-
18
-
5
-
-
-
-
-
-
-
-
23
13
-
-
-
-
-
-
-
27
-
-
-
-
-
-
27
-
-
-
-
20
-
-
-
8
-
18
-
-
-
-
-
-
-
-
23
13
-
-
-
-
-
-
-
-
-
5
5
-
-
-
716674
Panosa
Ribonucleotide reductases of S ...
Salmonella enterica subsp. enterica serovar Typhimurium
PLoS ONE
5
e11328
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
2
-
-
-
716920
Boal
Structural basis for activatio ...
Escherichia coli
Science
329
1526-1530
2010
1
-
-
1
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
2
1
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
701536
Ogata
Crystallization and preliminar ...
Corynebacterium ammoniagenes
Acta Crystallogr. Sect. F
65
878-880
2009
-
-
1
1
-
-
-
-
-
2
-
1
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
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-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702161
Zhu
Inhibitory mechanisms of heter ...
Homo sapiens
Biochem. Pharmacol.
78
1178-1185
2009
1
-
1
-
-
-
11
-
-
2
-
-
-
1
-
-
1
-
-
2
-
-
1
1
1
-
-
-
2
-
-
-
-
-
-
1
-
1
-
-
-
-
-
11
-
-
-
2
-
-
-
-
-
1
-
2
-
-
1
1
1
-
-
-
2
-
-
-
-
1
1
-
-
-
702259
Smith
2.6 a X-ray crystal structure ...
Homo sapiens
Biochemistry
48
11134-11141
2009
1
-
1
1
-
-
1
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
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-
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-
1
-
-
-
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-
-
-
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-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
1
1
-
-
-
703813
Abbouni
Electron paramagnetic resonanc ...
Corynebacterium glutamicum, Corynebacterium glutamicum R163
Free Radic. Res.
43
943-950
2009
1
-
-
-
-
-
4
-
-
2
1
-
-
7
-
-
1
-
-
-
1
-
2
2
-
-
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
3
4
-
-
-
2
1
-
-
-
-
1
-
-
1
-
2
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704176
Jensen
Peroxo-type intermediates in c ...
Escherichia coli
J. Am. Chem. Soc.
131
12155-12171
2009
1
-
-
-
3
-
-
-
-
1
-
-
-
2
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
704195
Offenbacher
Redox-linked structural change ...
Escherichia coli
J. Am. Chem. Soc.
131
7496-7497
2009
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
704612
Voevodskaya
Redox intermediates of the Mn- ...
Chlamydia trachomatis
J. Biol. Chem.
284
4555-4566
2009
2
-
-
1
-
-
1
-
-
3
-
-
-
3
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
1
-
-
-
2
-
-
1
1
-
-
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
706308
Yoo
Rice virescent3 and stripe1 en ...
Oryza sativa
Plant Physiol.
150
388-401
2009
-
-
1
-
1
-
1
-
1
-
-
-
-
2
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
2
-
-
2
-
-
-
-
-
-
-
-
4
-
-
-
2
-
-
-
-
-
-
-
-
-
2
4
-
-
-
706318
Roa
Ribonucleotide reductase regul ...
Arabidopsis thaliana
Plant Physiol.
151
461-471
2009
-
-
1
-
2
-
-
-
-
-
-
3
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
3
-
-
-
685235
Jiang
Rapid and quantitative activat ...
Chlamydia trachomatis
Biochemistry
47
4477-4483
2008
3
1
-
-
-
-
-
1
-
-
-
1
-
4
1
-
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
2
-
-
-
3
1
-
2
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
1
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
685275
Jiang
Branched activation- and catal ...
Chlamydia trachomatis
Biochemistry
47
8477-8484
2008
1
-
1
-
3
-
-
-
-
2
-
1
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
2
-
-
-
1
-
1
2
-
3
-
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
687199
Odenike
Phase I study of the ribonucle ...
Homo sapiens
Invest. New Drugs
26
233-239
2008
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
687333
Sen
Quercetin interferes with iron ...
Leishmania donovani, Leishmania donovani MHOM/IN/1983/AG83
J. Antimicrob. Chemother.
61
1066-1075
2008
-
1
-
-
-
-
1
-
-
1
-
4
-
2
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
1
-
-
-
-
1
-
-
-
1
-
4
-
-
-
-
-
1
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688283
Cappellacci
Ribose-modified purine nucleos ...
Homo sapiens
J. Med. Chem.
51
4260-4269
2008
-
-
-
-
-
-
9
-
-
-
-
-
-
1
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688286
Xu
The structural basis for pepti ...
Saccharomyces cerevisiae
J. Med. Chem.
51
4653-4659
2008
-
1
1
1
1
-
2
-
-
-
-
2
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
-
-
-
-
1
-
-
2
-
1
1
1
1
1
-
2
2
-
-
-
-
-
2
-
-
-
1
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
688754
Karp
A phase I study of the novel r ...
Homo sapiens
Leuk. Res.
32
71-77
2008
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
702216
Tomter
Circular dichroism and magneti ...
Bacillus cereus
Biochemistry
47
11300-11309
2008
-
-
1
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702226
Jiang
Formation and function of the ...
Chlamydia trachomatis, Escherichia coli
Biochemistry
47
13736-13744
2008
1
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4
2
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702551
Krishnan
Synthesis and ribonucleotide r ...
Homo sapiens
Bioorg. Med. Chem. Lett.
18
6248-6250
2008
1
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1
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24
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24
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1
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676888
Zhang
Role of the C terminus of the ...
Escherichia coli, Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
104
2217-2222
2007
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3
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2
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676901
Friedrich
Insertion of a homing endonucl ...
Aeromonas virus Aeh1
Proc. Natl. Acad. Sci. USA
104
6176-6181
2007
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1
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677078
Cerqueira
Ribonucleotide reductase: a cr ...
Escherichia coli
Recent Pat. Anticancer Drug Discov.
2
11-29
2007
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3
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1
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1
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684464
Avolio
RNA interference targeting the ...
Homo sapiens
Anticancer Drugs
18
377-388
2007
-
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1
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2
1
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1
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3
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2
1
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1
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1
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1
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1
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3
-
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2
1
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685023
Sigmond
The synergistic interaction of ...
Homo sapiens
Biochem. Pharmacol.
73
1548-1557
2007
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3
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1
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5
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5
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1
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686137
Heidel
Potent siRNA inhibitors of rib ...
Mus musculus
Clin. Cancer Res.
13
2207-2215
2007
-
1
1
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1
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1
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1
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1
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-
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686735
Voevodskaya
High catalytic activity achiev ...
Chlamydia trachomatis
FEBS Lett.
581
3351-3355
2007
2
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1
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1
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1
1
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4
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2
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1
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1
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1
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3
1
1
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1
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4
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1
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3
1
1
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1
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687294
Reece
Photoactive peptides for light ...
Escherichia coli
J. Am. Chem. Soc.
129
8500-8509
2007
1
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1
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1
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1
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3
1
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1
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688244
Kowol
Gallium(III) and iron(III) com ...
Homo sapiens, Mus musculus
J. Med. Chem.
50
1254-1265
2007
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29
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29
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688589
Nurbo
Design, synthesis and evaluati ...
Mycobacterium tuberculosis
J. Pept. Sci.
13
822-832
2007
2
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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1
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-
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671737
Qiu
Characterization of enzymatic ...
Homo sapiens
Biochem. Biophys. Res. Commun.
340
428-434
2006
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1
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1
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-
-
-
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672077
Ortigosa
Determination of the in vivo s ...
Saccharomyces cerevisiae
Biochemistry
45
12282-12294
2006
-
-
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-
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1
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1
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-
1
1
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-
-
-
-
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-
-
-
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-
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-
672201
Saleh
Cation mediation of radical tr ...
Escherichia coli
Biochemistry
45
8823-8830
2006
-
-
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3
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2
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1
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672641
Cerqueira
Dehydration of ribonucleotides ...
Escherichia coli
Biophys. J.
90
2109-2119
2006
-
-
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1
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1
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672909
Gautam
Suppression of lung tumor form ...
Homo sapiens, Mus musculus
Cancer Res.
66
6497-6502
2006
-
2
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2
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1
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1
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-
-
-
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-
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-
-
-
-
-
-
-
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674193
Seyedsayamdost
Site-specific replacement of Y ...
Escherichia coli
J. Am. Chem. Soc.
128
2522-2523
2006
-
-
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1
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1
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1
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674627
Torrents
Ribonucleotide reductase modul ...
Pseudomonas aeruginosa
J. Biol. Chem.
281
25287-25296
2006
1
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1
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2
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2
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1
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3
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1
2
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1
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1
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2
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2
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3
-
1
2
-
-
-
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-
-
-
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-
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674631
Narvaez
The involvement of Arg265 of m ...
Mus musculus
J. Biol. Chem.
281
26022-26028
2006
-
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4
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1
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4
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1
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4
-
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4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674645
Rofougaran
Enzymatically active mammalian ...
Mus musculus
J. Biol. Chem.
281
27705-27711
2006
-
-
-
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-
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2
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1
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1
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2
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-
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1
-
-
-
-
-
-
-
-
-
-
-
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-
676853
Xu
Structures of eukaryotic ribon ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
103
4022-4027
2006
-
-
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1
-
-
-
-
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1
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1
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1
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-
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-
-
-
-
-
-
-
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676854
Xu
Structures of eukaryotic ribon ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
103
4028-4033
2006
-
-
-
1
-
-
-
-
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1
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1
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676879
Voevodskaya
Chlamydial ribonucleotide redu ...
Chlamydia trachomatis
Proc. Natl. Acad. Sci. USA
103
9850-9854
2006
-
-
-
-
-
-
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1
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4
-
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1
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-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
657780
Schroeder
Loss of the tyrosyl radical in ...
Homo sapiens, Mus musculus
Biochem. Biophys. Res. Commun.
326
614-617
2005
-
-
-
-
-
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2
-
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-
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2
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2
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2
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2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657886
Shao
Determination of the potency a ...
Homo sapiens
Biochem. Pharmacol.
69
627-634
2005
-
-
-
-
-
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3
-
-
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-
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1
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1
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3
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1
-
-
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-
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-
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-
-
658677
He
The enantioselectivities of th ...
Mus musculus
FEBS J.
272
1236-1242
2005
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
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3
-
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1
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1
1
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-
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-
-
-
3
-
-
-
-
-
-
-
-
-
-
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-
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-
659447
Kolberg
A new tyrosyl radical on Phe20 ...
Escherichia coli
J. Biol. Chem.
280
11233-11246
2005
-
-
-
1
1
-
-
-
-
1
-
-
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2
-
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1
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1
1
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1
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1
-
-
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-
-
-
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-
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-
659460
Birgander
Nucleotide-dependent formation ...
Escherichia coli
J. Biol. Chem.
280
14997-15003
2005
-
-
-
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1
-
-
-
-
-
-
1
-
1
-
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3
1
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1
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1
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1
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3
1
-
-
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1
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-
-
-
-
-
-
-
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-
659727
Bracchi-Ricard
Two Plasmodium falciparum ribo ...
Plasmodium falciparum
J. Mol. Biol.
347
749-758
2005
-
-
-
-
-
-
-
-
-
-
4
-
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1
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1
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-
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-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671182
Cooperman
Peptide inhibitors of mammalia ...
Mus musculus
Adv. Enzyme Regul.
45
112-125
2005
-
-
-
-
-
-
5
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671998
Perlstein
The active form of the Sacchar ...
Saccharomyces cerevisiae
Biochemistry
44
15366-15377
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
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-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672581
Fuertes
Design, synthesis, and evaluat ...
Mus musculus
Bioorg. Med. Chem. Lett.
15
5146-5149
2005
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674162
Pierce
Local and global effects of me ...
Escherichia coli
J. Am. Chem. Soc.
127
3613-3623
2005
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659994
Larsson
Structural mechanism of allost ...
Thermotoga maritima
Nat. Struct. Mol. Biol.
11
1142-1149
2004
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
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-
-
-
-
1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657491
Cooperman
A comprehensive model for the ...
Mus musculus
Adv. Enzyme Regul.
43
167-182
2003
1
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660357
Yao
Subcellular localization of ye ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
100
6628-6633
2003
-
-
-
-
-
-
-
-
2
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660530
Lang
-
Synthesis of 8-vinyladenosine ...
Escherichia coli
Tetrahedron
59
7315-7322
2003
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437988
Smalley
Aerobic-type ribonucleotide re ...
Bacteroides fragilis
J. Bacteriol.
184
895-903
2002
1
-
1
-
-
-
2
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437989
Yun
Facile electron transfer durin ...
Mus musculus
Biochemistry
41
981-990
2002
-
-
1
-
1
-
-
-
-
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437990
Kashlan
A comprehensive model for the ...
Mus musculus
Biochemistry
41
462-474
2002
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
4
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
4
-
-
-
-
-
-
-
-
-
-
437986
Roshick
Cloning and characterization o ...
Chlamydia trachomatis
J. Biol. Chem.
275
38111-38119
2000
-
-
1
-
3
-
1
-
-
1
-
-
-
1
-
-
1
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
1
-
-
-
1
-
-
-
-
-
1
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437987
Reichard
Cross-talk between the alloste ...
Mus musculus
J. Biol. Chem.
275
33021-33026
2000
5
-
-
-
1
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437984
Nguyen
Purification of ribonucleotide ...
Saccharomyces cerevisiae
Proc. Natl. Acad. Sci. USA
96
12339-12344
1999
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437985
Rova
Evidence by mutagenesis that T ...
Mus musculus
J. Biol. Chem.
274
23746-23751
1999
-
-
1
-
2
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437981
Fieschi
The manganese-containing ribon ...
Corynebacterium ammoniagenes
J. Biol. Chem.
273
4329-4337
1998
3
-
1
-
-
-
1
-
-
1
3
-
-
1
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
1
-
-
-
1
3
-
-
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437982
Tong
Characterization of Y122F R2 o ...
Escherichia coli
Biochemistry
37
5840-5848
1998
-
-
1
-
3
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
3
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437983
Hamann
Chimeric small subunit inhibit ...
Escherichia coli, Mus musculus
Protein Eng.
11
219-224
1998
-
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437980
Hendricks
Regulation of T4 phage aerobic ...
Escherichia virus T4
J. Biol. Chem.
272
2861-2865
1997
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
723666
Riera
Ribonucleotide reductase in th ...
Pyrococcus furiosus
Proc. Natl. Acad. Sci. USA
94
475-478
1997
-
-
1
-
-
-
1
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
1
-
-
-
1
-
-
1
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
437979
Racay
Purification and partial chara ...
Kitasatospora aureofaciens
Biochem. Mol. Biol. Int.
38
493-500
1996
-
-
-
-
-
-
-
-
-
1
2
-
-
1
-
-
1
-
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
-
-
-
-
1
-
-
1
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437977
Sinhababu
High-performance liquid chroma ...
Oryctolagus cuniculus
Arch. Biochem. Biophys.
317
285-291
1995
3
-
-
-
-
-
3
2
-
-
-
-
-
3
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
-
3
2
2
-
-
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437978
Cory
-
Differential substrate propert ...
Mus musculus
Purine and pyrimidine metabolism in man VIII ed. (Sahota A. and Taylor M. ed.)
631-635
1995
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437975
Young
Ribonucleotide reductase: evid ...
Homo sapiens
Biochem. Biophys. Res. Commun.
203
46-52
1994
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437976
Jordan
A second class I ribonucleotid ...
Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium
Proc. Natl. Acad. Sci. USA
91
12892-12896
1994
6
-
-
-
-
-
2
4
-
4
2
-
-
6
-
-
1
-
-
-
2
-
4
2
-
-
-
-
1
-
-
-
-
-
-
6
-
-
-
-
-
-
-
2
-
4
-
4
2
-
-
-
-
1
-
-
2
-
4
2
-
-
-
-
1
-
-
-
-
-
-
-
-
-
437973
Ong
2'-C-Methyladenosine and 2'-C- ...
Corynebacterium nephridii
Biochemistry
32
11397-11404
1993
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
4
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437974
Slabaugh
Vaccinia virus ribonucleotide ...
Vaccinia virus
J. Biol. Chem.
268
17803-17810
1993
3
-
1
-
-
1
-
-
-
1
-
-
-
1
-
-
1
-
-
-
1
1
1
-
-
-
-
-
1
1
-
-
-
-
-
3
-
1
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
1
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
675339
Nordlund
Structure and function of the ...
Escherichia coli
J. Mol. Biol.
232
123-164
1993
-
-
-
1
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437927
Sahlin
Activation of the iron-contain ...
Escherichia coli
Biochem. Biophys. Res. Commun.
167
813-818
1990
1
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437935
Yang
The carboxyl terminus heptapep ...
Bos taurus
FEBS Lett.
272
61-64
1990
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
2
1
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437936
Stubbe
Ribonucleotide reductases ...
Escherichia coli, Herpes simplex virus, Mus musculus
Adv. Enzymol. Relat. Areas Mol. Biol.
63
349-419
1990
-
-
1
-
2
-
11
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-
2
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3
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2
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437938
Stubbe
Ribonucleotide reductases: ama ...
Escherichia coli
J. Biol. Chem.
265
5329-5332
1990
2
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6
-
4
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-
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1
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437941
Nordlund
Three-dimensional structure of ...
Escherichia coli
Nature
345
593-598
1990
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1
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437925
Whitefield
Ribonucleotide reductase - new ...
Rattus norvegicus
Adv. Enzyme Regul.
28
113-123
1989
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1
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437926
carter
Selective resistance of L1210 ...
Mus musculus
Adv. Enzyme Regul.
29
123-139
1989
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1
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437928
Smith
Stereoselective, strong inhibi ...
Escherichia coli
Biochem. Biophys. Res. Commun.
162
715-723
1989
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437942
Nordlund
New crystal forms of the small ...
Escherichia coli
FEBS Lett.
258
251-254
1989
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437943
Thelander
Molecular cloning and expressi ...
Mus musculus
EMBO J.
8
2475-2479
1989
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1
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437944
Caras
Molecular cloning of the cDNA ...
Mus musculus
Mol. Cell. Biol.
8
2698-2704
1988
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437929
Harder
-
Characterization of the free r ...
Tetradesmus obliquus
FEBS Lett.
222
171-174
1987
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437945
Ribi
Two-dimensional crystals of en ...
Escherichia coli
Biochemistry
26
7974-7979
1987
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437946
Bunker
Extended X-ray absorption fine ...
Escherichia coli
Biochemistry
26
4708-4716
1987
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437924
Salowe
Cloning, overproduction, and p ...
Escherichia coli
J. Bacteriol.
165
363-366
1986
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437930
Cory
Protein properties of the subu ...
Mus musculus
Adv. Enzyme Regul.
25
3-19
1986
2
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6
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437934
Sato
Differential sensitivities of ...
Mus musculus
Arch. Biochem. Biophys.
244
572-579
1986
1
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437947
Thelander
Isolation and characterization ...
Mus musculus
Mol. Cell. Biol.
6
3433-3442
1986
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437950
Nikas
Structural features of ribonuc ...
Herpes simplex virus
Proteins Struct. Funct. Genet.
1
376-384
1986
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437923
Spector
Herpes simplex type 1 ribonucl ...
Herpes simplex virus
J. Biol. Chem.
260
8694-8697
1985
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437932
Hofmann
-
Deoxyribonucleotide biosynthes ...
Tetradesmus obliquus
Biochim. Biophys. Acta
832
98-112
1985
3
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437933
Cory
Nucleoside 5'-diphosphates as ...
Mus musculus
J. Biol. Chem.
260
12001-12007
1985
5
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437919
Hards
Ribonucleotide reductase activ ...
Cricetulus griseus
Arch. Biochem. Biophys.
231
9-16
1984
5
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437920
Sato
Studies on the differential me ...
Mus musculus
Adv. Enzyme Regul.
22
231-241
1984
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6
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437921
Joelson
Crystallization and preliminar ...
Escherichia coli
J. Biol. Chem.
259
9076-9077
1984
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1
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437922
Slabaugh
Vaccinia virus induces ribonuc ...
Platyrrhini
J. Virol.
52
507-514
1984
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4
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4
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3
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1
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437931
Averett
Ribonucleotide reductase of he ...
Herpes simplex virus
J. Virol.
52
981-983
1984
-
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4
2
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2
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1
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-
437951
Fitzgerald
Inhibition of ribonucleotide r ...
Mus musculus
Biochem. Biophys. Res. Commun.
120
1008-1014
1984
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2
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1
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2
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2
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1
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437952
Engström
Localization of ribonucleotide ...
Mus musculus, Rattus norvegicus
EMBO J.
3
863-867
1984
-
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2
-
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2
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3
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2
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2
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3
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2
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-
437910
Huszar
-
Is ribonucleotide reductase th ...
Herpes simplex virus
Nature
302
77-79
1983
-
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1
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2
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1
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3
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1
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2
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3
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437917
Averett
Ribonucleotide reductase induc ...
Mesocricetus auratus
J. Biol. Chem.
258
9831-9838
1983
-
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-
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-
18
4
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1
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2
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2
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1
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12
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18
12
4
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2
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2
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-
1
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-
437918
Lammers
-
The ribonucleotide reductases ...
Bos taurus, Enterobacteria phage T6, Escherichia coli, Escherichia virus T4, Escherichia virus T5, Homo sapiens, Mesocricetus auratus, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Saccharomyces cerevisiae, Tetradesmus obliquus
Struct. Bonding
54
27-91
1983
54
-
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-
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-
85
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-
17
14
9
-
12
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9
-
6
-
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26
9
-
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-
54
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-
85
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17
14
9
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6
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26
9
-
-
-
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-
-
-
-
-
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-
437953
Reichard
Ribonucleotide reductase - a r ...
Escherichia coli
Science
221
514-519
1983
-
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1
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1
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-
1
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-
1
1
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-
-
-
-
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-
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-
-
-
-
-
-
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-
1
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-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437954
Cook
Properties of Bacteriophage T4 ...
Escherichia virus T4
J. Biol. Chem.
258
6064-6072
1983
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
-
-
-
1
1
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-
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-
-
-
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-
-
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-
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2
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-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437955
Stubbe
Mechanism of ribonucleoside di ...
Escherichia coli
J. Biol. Chem.
258
1625-1630
1983
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
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-
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-
1
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437907
Kucera
Studies on ribonucleoside-diph ...
Mus musculus
Arch. Biochem. Biophys.
214
114-123
1982
7
-
-
-
-
-
11
2
-
-
-
-
-
3
-
-
1
-
-
-
-
-
5
-
-
-
-
-
-
-
-
1
-
-
-
7
-
-
1
-
-
-
-
11
-
2
-
-
-
-
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437909
Kjoller Larsen
Characterization of the active ...
Bos taurus, Escherichia coli, Escherichia virus T4, Mus musculus
Eur. J. Biochem.
125
75-81
1982
-
-
-
-
-
-
20
-
-
-
-
-
-
4
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
20
-
-
-
-
-
-
-
-
-
-
-
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437960
Kucera
Studied on ribonucleoside-diph ...
Mus musculus
Arch. Biochem. Biophys.
214
102-113
1982
-
-
-
-
-
-
1
-
1
-
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-
-
3
-
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-
-
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2
-
-
1
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-
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1
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1
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-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437961
Cory
The molecular weight of Ehrlic ...
Mus musculus
Arch. Biochem. Biophys.
217
546-551
1982
-
-
-
-
-
-
-
-
-
-
-
-
-
1
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-
-
3
-
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1
1
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-
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-
-
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-
-
3
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437962
Youdale
Rat liver ribonucleotide reduc ...
Rattus norvegicus
Can. J. Biochem.
60
463-470
1982
-
-
-
-
-
-
-
1
-
1
2
-
-
1
-
-
1
-
-
1
2
1
1
2
-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
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-
1
-
1
2
-
-
-
-
1
-
1
2
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437914
Elford
Regulation of ribonucleotide r ...
Homo sapiens
Adv. Enzyme Regul.
19
151-168
1981
-
-
-
-
-
-
38
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
38
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437915
Cory
Specific inhibition of the sub ...
Mus musculus
Adv. Enzyme Regul.
19
139-150
1981
-
-
-
-
-
-
8
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437916
Mattaliano
Purification of the two comple ...
Bos taurus
Biochem. Biophys. Res. Commun.
102
667-674
1981
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
1
-
-
1
-
-
1
1
-
-
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-
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-
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-
-
-
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-
2
-
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-
-
1
-
1
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437937
Holmgren
Regulation of ribonucleotide r ...
Bos taurus, Enterobacteria phage T2, Enterobacteria phage T6, Escherichia coli, Escherichia virus T4, Escherichia virus T5, Homo sapiens, Oryctolagus cuniculus, Rattus norvegicus
Curr. Top. Cell. Regul.
19
47-76
1981
27
-
-
-
-
-
40
-
-
-
-
-
-
9
-
-
-
-
-
2
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
27
-
-
-
-
-
-
-
40
-
-
-
-
-
-
-
-
-
-
-
2
-
-
9
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437963
Gudas
Purification of a mutant ribon ...
Mus musculus
Adv. Enzyme Regul.
19
129-137
1981
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
3
1
-
1
-
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-
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-
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-
-
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-
-
-
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-
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-
-
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1
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437964
Huszar
Partial purification and chara ...
Herpes simplex virus
J. Virol.
37
580-588
1981
-
-
-
-
-
-
5
-
-
1
-
-
-
1
-
-
1
-
-
-
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
1
-
-
-
-
-
1
-
-
-
2
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
437958
Sjöberg
Ribonucleotide reductase: a st ...
Escherichia coli
Biochem. Biophys. Res. Commun.
94
793-799
1980
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
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-
1
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-
-
-
-
-
-
-
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-
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-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437959
Petersson
The iron center in ribonucleot ...
Escherichia coli
J. Biol. Chem.
255
6706-6712
1980
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
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-
-
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-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437956
Berglund
Effect of hydroxyurea on T4 ri ...
Escherichia virus T4
J. Biol. Chem.
254
253-254
1979
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437965
Engström
Ribonucleotide reductase from ...
Bos taurus, Escherichia coli
Biochemistry
18
2941-2948
1979
-
-
-
-
-
-
7
-
-
5
-
-
-
2
-
-
1
-
-
1
2
1
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
7
1
-
-
5
-
-
-
-
-
1
-
1
2
1
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
437913
Thelander
Ribonucleoside diphosphate red ...
Escherichia coli, Escherichia coli overproducing
Methods Enzymol.
51
227-237
1978
5
-
-
-
-
-
-
-
-
-
-
-
-
10
-
-
1
-
-
-
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437966
Hopper
Ribonucleotide reductase of ra ...
Oryctolagus cuniculus
Methods Enzymol.
51
237-246
1978
-
-
-
-
-
1
2
-
-
-
-
-
-
1
-
-
1
-
-
1
1
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
1
-
1
1
3
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437967
Feller
Ribonucleotide reductase activ ...
Auxenochlorella pyrenoidosa, Tetradesmus obliquus
Biochem. Biophys. Res. Commun.
70
752-758
1976
3
-
-
-
-
-
4
-
-
4
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
4
-
-
-
4
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437940
Thelander
Physicochemical characterizati ...
Escherichia coli
J. Biol. Chem.
248
4591-4601
1973
-
-
-
-
-
-
1
-
-
1
2
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437957
Atkin
Iron and free radical in ribon ...
Escherichia coli
J. Biol. Chem.
248
7464-7472
1973
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437969
Larsson
Ribonucleotide reductase from ...
Rattus norvegicus
Biochim. Biophys. Acta
324
447-451
1973
2
-
-
-
-
-
3
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437911
Berglund
Ribonucleoside diphosphate red ...
Escherichia virus T4
J. Biol. Chem.
247
7270-7275
1972
2
-
-
-
-
2
-
1
-
2
2
-
-
1
-
-
1
-
-
-
1
1
1
1
-
-
-
-
1
-
-
2
-
-
-
2
-
-
2
-
-
2
-
-
-
1
-
2
2
-
-
-
-
1
-
-
1
1
1
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
437912
Berglund
Ribonucleoside diphosphate red ...
Escherichia virus T4
J. Biol. Chem.
247
7276-7281
1972
5
-
-
-
-
-
2
11
-
-
-
-
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
8
-
-
5
-
-
1
-
-
-
-
2
8
11
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437949
Hopper
Ribonucleotide reductase of ra ...
Oryctolagus cuniculus
J. Biol. Chem.
247
3336-3340
1972
2
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
1
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437968
Elford
Functional regulation of mamma ...
Rattus norvegicus
Adv. Enzyme Regul.
10
19-38
1972
-
-
-
-
-
-
-
-
1
-
-
2
-
1
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437948
Vitols
Ribonucleotide reductase from ...
Herpes simplex virus, Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
41
71-77
1970
1
-
-
-
-
1
4
1
-
-
-
-
-
2
-
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
4
-
1
-
-
-
-
-
-
-
-
-
-
1
1
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437908
Moore
Regulation of mammalian deoxyr ...
Rattus norvegicus
J. Biol. Chem.
241
4802-4809
1966
4
-
-
-
-
-
4
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
437939
Larsson
Enzymatic synthesis of deoxyri ...
Escherichia coli
J. Biol. Chem.
241
2533-2539
1966
-
-
-
-
-
-
3
3
-
1
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
3
2
3
-
1
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-