Literature summary for 1.17.4.1 extracted from

Foskolou, I.P.; Jorgensen, C.; Leszczynska, K.B.; Olcina, M.M.; Tarhonskaya, H.; Haisma, B.; DAngiolella, V.; Myers, W.K.; Domene, C.; Flashman, E.; Hammond, E.M.
Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication (2017), Mol. Cell, 66, 206-220.e9 .

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q7LG56	subunit RRM2B	-

Oxidation Stability

Oxidation Stability	Organism
in hypoxic conditions the small subunit of the ribonucleotide reductase enzyme is switched from RRM2 to RRM2B in order to facilitate nucleotide production and ongoing replication. Specific residues within RRM2B are identified that are responsible for maintaining activity in hypoxia. RRM2B retains activity in hypoxic conditions and is the favored ribonucleotide reductase subunit in hypoxia. Loss of RRM2B has detrimental consequences for cell fate, specifically in hypoxia	Homo sapiens

Organism

in hypoxic conditions the small subunit of the ribonucleotide reductase enzyme is switched from RRM2 to RRM2B in order to facilitate nucleotide production and ongoing replication. Specific residues within RRM2B are identified that are responsible for maintaining activity in hypoxia. RRM2B retains activity in hypoxic conditions and is the favored ribonucleotide reductase subunit in hypoxia. Loss of RRM2B has detrimental consequences for cell fate, specifically in hypoxia

Homo sapiens

Subunits

Subunits	Comment	Organism
More	in hypoxic conditions the small subunit of the ribonucleotide reductase enzyme is switched from RRM2 to RRM2B in order to facilitate nucleotide production and ongoing replication. Specific residues within RRM2B are identified that are responsible for maintaining activity in hypoxia	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	subunit RRM2B is induced in response to hypoxia	up

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Release 2023.1 (January 2023)