Reference on EC 1.14.14.23 - cholesterol 7alpha-monooxygenase and Organism(s) Homo sapiens and UniProt Accession P22680
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Erickson, S.K.; Bsterling, B.
Cholesterol 7alpha-hydroxylase from human liver: partial purification and reconstruction into defined phospholipid-cholesterol vesicles
J. Lipid Res.
22
872-876
1981
Homo sapiens
Nguyen, L.B.; Shefer, S.; Salen, G.; Ness, G.; Tanaka, R.D.; Packin, V.; Thomas, P.; Shore, V.; Batta, A.
Purification of cholesterol 7alpha-hydroxylase from human and rat liver and production of inhibiting polyclonal antibodies
J. Biol. Chem.
265
4541-4546
1990
Homo sapiens, Rattus norvegicus
Nguyen, L.B.; Shefer, S.; Salen, G.; Chiang, J.Y.L.; Patel, M.
Cholesterol 7alpha-hydroxylase activities from human and rat liver are modulated in vitro posttranslationally by phosphorylation/dephosphorylation
Hepatology
24
1468-1474
1996
Homo sapiens, Rattus norvegicus
Galman, C.; Arvidsson, I.; Angelin, B.; Rudling, M.
Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood
J. Lipid Res.
44
859-866
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Kinowaki, M.; Tanaka, S.; Maeda, Y.; Higashi, S.; Okuda, K.; Setoguchi, T.
Half-life of cholesterol 7alpha-hydroxylase activity and enzyme mass differ in animals and humans when determined by a monoclonal antibody against human cholesterol 7alpha-hydroxylase
J. Steroid Biochem. Mol. Biol.
81
377-380
2002
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Tanaka, S.; Kinowaki, M.; Eto, T.A.; Ota, Y.; Maeda, Y.; Okuda, K.; Setoguchi, T.; Chijiiwa, K.
Sulfhydryl groups responsible for extreme lability of human cholesterol 7alpha-hydroxylase identified by site-directed mutagenesis
J. Steroid Biochem. Mol. Biol.
86
35-40
2003
Cricetulus griseus, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus
Tiemann, M.; Han, Z.; Soccio, R.; Bollineni, J.; Shefer, S.; Sehayek, E.; Breslow, J.L.
Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity
Proc. Natl. Acad. Sci. USA
101
1846-1851
2004
Homo sapiens, Mus musculus
Abrahamsson, A.; Krapivner, S.; Gustafsson, U.; Muhrbeck, O.; Eggertsen, G.; Johansson, I.; Persson, I.; Angelin, B.; Ingelman-Sundberg, M.; Bjoerkhem, I.; Einarsson, C.; vant Hooft, F.M.
Common polymorphisms in the CYP7A1 gene do not contribute to variation in rates of bile acid synthesis and plasma LDL cholesterol concentration
Atherosclerosis
182
37-45
2005
Homo sapiens
Stroup, D.; Ramsaran, J.R.
Cholesterol 7alpha-hydroxylase is phosphorylated at multiple amino acids
Biochem. Biophys. Res. Commun.
329
957-965
2005
Homo sapiens (P22680), Homo sapiens
Charoenteeraboon, J.; Nithipatikom, K.; Campbell, W.B.; Piyachaturawat, P.; Wilairat, P.; Rongnoparut, P.
Induction of human cholesterol 7alpha-hydroxylase in HepG2 cells by 2,4,6-trihydroxyacetophenone
Eur. J. Pharmacol.
515
43-46
2005
Homo sapiens
Li, T.; Kong, X.; Owsley, E.; Ellis, E.; Strom, S.; Chiang, J.Y.
Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c
J. Biol. Chem.
281
28745-28754
2006
Homo sapiens (P22680), Homo sapiens
Hubacek, J.A.; Bobkova, D.
Role of cholesterol 7alpha-hydroxylase (CYP7A1) in nutrigenetics and pharmacogenetics of cholesterol lowering
Mol. Diagn. Ther.
10
93-100
2006
Homo sapiens (P22680)
Lee, M.S.; Park, J.Y.; Freake, H.; Kwun, I.S.; Kim, Y.
Green tea catechin enhances cholesterol 7alpha-hydroxylase gene expression in HepG2 cells
Br. J. Nutr.
99
1182-1185
2008
Homo sapiens
Mitro, N.; Godio, C.; De Fabiani, E.; Scotti, E.; Galmozzi, A.; Gilardi, F.; Caruso, D.; Chacon, A.B.; Crestani, M.
Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis
Hepatology
46
885-897
2007
Homo sapiens (P22680)
Srivastava, A.; Pandey, S.N.; Choudhuri, G.; Mittal, B.
Role of genetic variant A-204C of cholesterol 7alpha-hydroxylase (CYP7A1) in susceptibility to gallbladder cancer
Mol. Genet. Metab.
94
83-89
2008
Homo sapiens
Gilardi, F.; Mitro, N.; Godio, C.; Scotti, E.; Caruso, D.; Crestani, M.; De Fabiani, E.
The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol
Pharmacol. Ther.
116
449-472
2007
Homo sapiens, Mus musculus
Li, T.; Ma, H.; Park, Y.J.; Lee, Y.K.; Strom, S.; Moore, D.D.; Chiang, J.Y.
Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice
Biochim. Biophys. Acta
1791
991-996
2009
Homo sapiens, Mus musculus
Han, S.; Chiang, J.Y.
Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes
Drug Metab. Dispos.
37
469-478
2009
Homo sapiens
Song, K.H.; Li, T.; Owsley, E.; Strom, S.; Chiang, J.Y.
Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression
Hepatology
49
297-305
2009
Homo sapiens
Nass, N.; Schoeps, R.; Ulbrich-Hofmann, R.; Simm, A.; Hohndorf, L.; Schmelzer, C.; Raith, K.; Neubert, R.H.; Eder, K.
Screening for nutritive peptides that modify cholesterol 7alpha-hydroxylase expression
J. Agric. Food Chem.
56
4987-4994
2008
Homo sapiens
Kovar, J.; Lenicek, V.; Zimolova, M.; Vitek, L.; Jirsa, M.; Pitha, P.
Regulation of diurnal variation of cholesterol 7alpha-hydroxylase (CYP7A1) activity in healthy subjects
Physiol. Res.
59
233-238
2010
Homo sapiens
De Castro-Oros, I.; Pampin, S.; Cofan, M.; Mozas, P.; Pinto, X.; Salas-Salvado, J.; Rodriguez-Rey, J.C.; Ros, E.; Civeira, F.; Pocovi, M.
Promoter variant -204A>C of the cholesterol 7alpha-hydroxylase gene: Association with response to plant sterols in humans and increased transcriptional activity in transfected HepG2 cells
Clin. Nutr.
30
239-246
2010
Homo sapiens
Song, K.H.; Li, T.; Owsley, E.; Chiang, J.Y.
A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes
J. Lipid Res.
51
2223-2233
2010
Homo sapiens
Li, T.; Chanda, D.; Zhang, Y.; -SikChoi, H.; Chiang, J.
Glucose stimulates cholesterol 7 alpha-hydroxylase gene transcription in human hepatocytes
J. Lipid Res.
51
832-842
2010
Homo sapiens
Michelini, E.; Donati, M.; Aldini, R.; Cevenini, L.; Mezzanotte, L.; Nardini, P.; Foschi, C.; Zvi, I.B.; Cevenini, M.; Montagnani, M.; Marangoni, A.; Roda, A.; Cevenini, R.
Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7alpha-hydroxylase (CYP7A1) transcription
Anal. Biochem.
430
92-96
2012
Homo sapiens
Li, T.; Francl, J.M.; Boehme, S.; Chiang, J.Y.
Regulation of cholesterol and bile acid homeostasis by the cholesterol 7alpha-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice
Hepatology
58
1111-1121
2013
Homo sapiens, Rattus norvegicus (P18125)
Shinkyo, R.; Xu, L.; Tallman, K.A.; Cheng, Q.; Porter, N.A.; Guengerich, F.P.
Conversion of 7-dehydrocholesterol to 7-ketocholesterol is catalyzed by human cytochrome P450 7A1 and occurs by direct oxidation without an epoxide intermediate
J. Biol. Chem.
286
33021-33028
2011
Homo sapiens
Chow, E.C.; Magomedova, L.; Quach, H.P.; Patel, R.; Durk, M.R.; Fan, J.; Maeng, H.J.; Irondi, K.; Anakk, S.; Moore, D.D.; Cummins, C.L.; Pang, K.S.
Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol
Gastroenterology
146
1048-1059
2014
Homo sapiens (P22680), Homo sapiens, Mus musculus (Q64505), Mus musculus, Mus musculus C57BL/6 (Q64505)
Tempel, W.; Grabovec, I.; MacKenzie, F.; Dichenko, Y.V.; Usanov, S.A.; Gilep, A.A.; Park, H.W.; Strushkevich, N.
Structural characterization of human cholesterol 7alpha-hydroxylase
J. Lipid Res.
55
1925-1932
2014
Homo sapiens (P22680), Homo sapiens
