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IUBMB CommentsRequires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil to oxidize its -CH2OH group first to -CHO and then to -COOH.
The taxonomic range for the selected organisms is: Trypanosoma brucei brucei
The enzyme appears in selected viruses and cellular organisms
Synonyms
thymine 7-hydroxylase, j-binding protein 1, thymidine hydroxylase, j-binding protein 2, thymine-7-hydroxylase, thymine hydroxylase,
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5-hydroxy-methyluracil dioxygenase
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5-hydroxy-methyluracil oxygenase
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thymine 7-hydroxylase
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thymine dioxygenase
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thymine,2-oxoglutarate:oxygen oxidoreductase (7-hydroxylating)
Requires Fe2+ and ascorbate. Also acts on 5-hydroxymethyluracil to oxidize its -CH2OH group first to -CHO and then to -COOH.
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