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Information on EC 1.1.1.218 - morphine 6-dehydrogenase

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IUBMB Comments
Also acts on some other alkaloids, including codeine, normorphine and ethylmorphine, but only very slowly on 7,8-saturated derivatives such as dihydromorphine and dihydrocodeine. In the reverse direction, also reduces naloxone to the 6alpha-hydroxy analogue. Activated by 2-mercaptoethanol.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Reaction Schemes
Synonyms
naloxone reductase, akr1c34, morphine-6-dehydrogenase, more
REACTION
REACTION DIAGRAM
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ORGANISM
UNIPROT
LITERATURE
morphine + NAD(P)+ = morphinone + NAD(P)H + H+
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