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2.9
-
cosubstrate NAD+, in the male adult rats
3.3
-
cosubstrate NAD+, in the female adult rats
0.063
-
isoenzymes from capsule tissue
0.0355
-
pH 7.5, 37°C, isozyme UGT1A8, at 0.05 mM morphine
0.0404
-
pH 7.5, 37°C, isozyme UGT1A1, at 0.05 mM morphine
0.0679
-
pH 7.5, 37°C, isozyme UGT1A1, at 2.5 mM morphine
0.0681
-
pH 7.5, 37°C, isozyme UGT1A8, at 2.5 mM morphine
0.2
-
isozyme UGT2B7 in COS-1 cell microsomes, pH 7.8, 37°C, in presence with CYP2C9
0.24
-
isoform Ugt2b36, at pH 7.4 and 37°C
0.33
-
apparent Km for UGT1B9, formation of 3-glucuronide
0.38
-
isozyme UGT2B7 in COS-1 cell microsomes, pH 7.8, 37°C
0.42
-
morphine 3-glucuronide formation, recombinant isozyme UGT2B7, pH 7.4, 37°C
0.48
-
isozyme UGT2B7 in COS-1 cell microsomes, pH 7.8, 37°C, in presence with CYP1A2
0.63
-
morphine 6-glucuronide formation, isozyme UGT2B7, pH 7.5, 37°C
0.67
-
morphine 3-glucuronide formation, isozyme UGT2B7, pH 7.5, 37°C
0.97
-
morphine 6-glucuronide formation, recombinant isozyme UGT2B7, pH 7.4, 37°C
1.18
-
liver microsomes, pH 7.8, 37°C
1.2
-
isoform UGT2B30, at pH 7.4, temperature not specified in the publication
1.3
-
isoform UGT2B9, at pH 7.4, temperature not specified in the publication
2.6
-
morphine 3-glucuronide formation, recombinant isozyme UGT1A8, pH 7.4, 37°C
2.7
-
enzyme from liver microsome, at pH 7.4, temperature not specified in the publication
3.2
-
morphine 3-glucuronide formation, recombinant isozyme UGT1A3, pH 7.4, 37°C
3.71
-
isozyme UGT2B7 in COS-1 cell microsomes, pH 7.8, 37°C, in presence with CYP3A4
7.3
-
membrane-bound recombinant isoform UGT1A10 from CHO cells, at pH 7.4 and 37°C
10.4
-
membrane-bound recombinant isoform UGT1A10 from HEK-293 cells, at pH 7.4 and 37°C
12.6
-
morphine 3-glucuronide formation, recombinant isozyme UGT1A10, pH 7.4, 37°C
18
-
morphine 3-glucuronide formation, recombinant isozyme UGT1A6, pH 7.4, 37°C
18.7
-
morphine 3-glucuronide formation, recombinant isozyme UGT1A1, pH 7.4, 37°C
37.4
-
morphine 3-glucuronide formation, recombinant isozyme UGT1A9, pH 7.4, 37°C
3.8
-
mutant P101H, pH 7.4, 37°C
4.6
-
wild-type, pH 7.4, 37°C
5
-
mutant R9C, pH 7.4, 37°C
5
-
mutant V15M, pH 7.4, 37°C
5.7
-
mutant T7P, pH 7.4, 37°C
5.7
-
mutant V18F, pH 7.4, 37°C
5.9
-
mutant P10L, pH 7.4, 37°C
6.2
-
mutant S290T, pH 7.4, 37°C
6.4
-
mutant P101L, pH 7.4, 37°C
7.2
-
mutant R144C, pH 7.4, 37°C
7.8
-
mutant S8P, pH 7.4, 37°C
8.3
-
mutant K234N, pH 7.4, 37°C
10
-
mutant N235T, pH 7.4, 37°C
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Purification and properties of codeinone reductase (NADPH) from Papaver somniferum cell cultures and differentiated plants
1995
Lenz, R.; Zenk, M.H.
Eur. J. Biochem.
233
132-139
-
Purification and properties of 1,2-dehydroreticuline reductase from Papaver somniferum seedlings
1992
De-Eknamkul, W.; Zenk, M.H.
Phytochemistry
31
813-821
-
Homogeneous 1,2-dehydroreticuline reductase from opium poppy plant
1991
De-Eknamkul, W.; Zenk, M.H.
Microb. Util. Renewable Resour.
7
87-98
Purification and characterization of guinea pig liver morphine 6-dehydrogenase
1985
Yamano, S; Kageura, E.; Ishida, T.; Toki, S.
J. Biol. Chem.
260
5259-5264
Guinea-pig liver morphine 6-dehydrogenase as a naloxone reductase
1986
Yamano, S.; Nishida, F; Toki, S.
Biochem. Pharmacol.
35
4321-4326
Microbial degradation of the morphine alkaloids: identification of morphinone as an intermediate in the metabolism of morphine by Pseudomonas putida M10
1990
Bruce, N.C.; Wilmot, C.J.; Jordan, K.N.; Trebilcock, A.E.; Stephens, L.D.G.; Lowe, Ch.R.
Arch. Microbiol.
154
465-470
-
Microbial degradation of the morphine alkaloids
1991
Bruce, N.C.; Wilmot, C.J.; Jordan, K.N.; Stephens, L.D.G.; Lowe, Ch.R.
Biochem. J.
274
875-880
Purification, characterization and partial primary structure of morphine 6-dehydrogenase from rabbit liver cytosol
1997
Yamano, S.; Ito, K.; Ogata, S.; Toki, S.
Arch. Biochem. Biophys.
341
81-88
In vivo and in vitro formation of morphinone from morphine in rat
1997
Yamano, S.; Takahashi, A.; Todaka, T.; Toki, S.
Xenobiotica
27
645-656
Purification and characterization of NAD-dependent morphine 6-dehydrogenase from hamster liver cytosol, a new member of the aldo-keto reductase superfamily
2000
Todaka, T.; Yamano, S.; Toki, S.
Arch. Biochem. Biophys.
374
189-197
Mechanistic studies of morphine dehydrogenase and stabilization against covalent inactivation
2000
Walker, E.H.; French, C.E.; Rathbone, D.A.; Bruce, N.C.
Biochem. J.
345
687-692
-
Identification and purification of multiple forms of UDP-glucuronosyltransferase
1981
Burchell, B.
Rev. Biochem. Toxicol.
3
1-32
Purification of rat-liver microsomal UDP-glucuronyltransferase. Separation of two enzyme forms inducible by 3-methylcholanthrene or phenobarbital
1979
Bock, K.W.; Josting, D.; Lilienblum, W.; Pfeil, H.
Eur. J. Biochem.
98
19-26
Purification and immunochemical characterization of a low-pI form of UDP glucuronosyltransferase from mouse liver
1984
Mackenzie, P.I.; Hjelmeland, L.M.; Owens, I.S.
Arch. Biochem. Biophys.
231
487-497
4-Nitrophenol UDPglucuronyltransferase (rat liver)
1981
Burchell, B.; Weatherill, P.
Methods Enzymol.
77
169-177
Substrate specificity and properties of uridine diphosphate glucuronyltransferase purified to apparent homogeneity from phenobarbital-treated rat liver
1978
Burchell, B.
Biochem. J.
173
749-757
Isolation and purification of rat liver morphine UDP-glucuronosyltransferase
1986
Puig, J.F.; Tephly, T.R.
Mol. Pharmacol.
30
558-565
UDP-glucuronosyltransferases
1989
Burchell, B.; Coughtrie, M.W.H.
Pharmacol. Ther.
43
261-289
Glucuronidation of opioids, carboxylic acid-containing drugs, and hydroxylated xenobiotics catalyzed by expressed monkey UDP-glucuronosyltransferase 2B9 protein
1997
Green, M.D.; Belanger, G.; Hum, D.W.; Belanger, A.; Tephly, T.R.
Drug Metab. Dispos.
25
1389-1394
-
Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase
1999
Jedlitschky, G.; Cassidy, A.J.; Sales, M.; Pratt, N.; Burchell, B.
Biochem. J.
340
837-843
Structural and functional studies of UDP-Glucuronosyltransferases
1999
Radominska-Pandya, A.; Czernik, P.J.; Little, J.M.; Battaglia, E.; Mackenzie, P.I.
Drug Metab. Rev.
31
817-899
Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenac
2001
King, C.; Tang, W.; Ngui, J.; Tephly, T.; Braun, M.
Toxicol. Sci.
61
49-53
Human UDP-glucuronosyltransferase 2B7
2001
Radominska-Pandya, A.; Little, J.M.; Czernik, P.J.
Curr. Drug Metab.
2
283-298
Observation of an arsenic adduct in an acetyl esterase crystal structure
2003
Zhu, X.; Larsen, N.A.; Basran, A.; Bruce, N.C.; Wilson, I.A.
J. Biol. Chem.
278
2008-2014
Effects of morphine administration and its withdrawal on rat brain aminopeptidase activities
2003
Irazusta, J.; Larrinaga, G.; Agirregoitia, N.; Varona, A.; Casis, L.
Regul. Pept.
110
225-230
Isoform selectivity and kinetics of morphine 3- and 6-glucuronidation by human UDP-glucuronosyltransferases: Evidence for atypical glucuronidation kinetics by UGT2B7
2003
Stone, A.N.; MacKenzie, P.I.; Galetin, A.; Houston, B.J.; Miners, J.O.
Drug Metab. Dispos.
31
1086-1089
Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism
2003
Court, M.H.; Krishnaswamy, S.; Hao, Q.; Duan, S.X.; Patten, C.J.; Von Moltke, L.L.; Greenblatt, D.J.
Drug Metab. Dispos.
31
1125-1133
Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1
2003
Watanabe, Y.; Nakajima, M.; Ohashi, N.; Kume, T.; Yokoi, T.
Drug Metab. Dispos.
31
589-595
The effect of incubation conditions on the enzyme kinetics of UDP-glucuronosyltransferases
2003
Soars, M.G.; Ring, B.J.; Wrighton, S.A.
Drug Metab. Dispos.
31
762-767
Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4
2005
Takeda, S.; Ishii, Y.; Iwanaga, M.; Mackenzie, P.I.; Nagata, K.; Yamazoe, Y.; Oguri, K.; Yamada, H.
Mol. Pharmacol.
67
665-672
Studies of the inhibition of serum pseudocholinesterase activity in vitro by commonly used drugs
2005
Bailey, D.N.; Briggs, J.R.
Am. J. Clin. Pathol.
124
226-228
Bioactivation of morphine in human liver: isolation and identification of morphinone, a toxic metabolite
2005
Todaka, T.; Ishida, T.; Kita, H.; Narimatsu, S.; Yamano, S.
Biol. Pharm. Bull.
28
1275-1280
Morphine glucuronosyltransferase activity in human liver microsomes is inhibited by a variety of drugs that are co-administered with morphine
2007
Hara, Y.; Nakajima, M.; Miyamoto, K.; Yokoi, T.
Drug Metab. Pharmacokinet.
22
103-112
Activity and expression of various isoforms of uridine diphosphate glucuronosyltransferase are differentially regulated during hepatic regeneration in rats
2005
Tian, H.; Ou, J.; Strom, S.C.; Venkataramanan, R.
Pharm. Res.
22
2007-2015
Finasteride, a 5alpha-reductase inhibitor, potentiates antinociceptive effects of morphine, prevents the development of morphine tolerance and attenuates abstinence behavior in the rat
2007
Verdi, J.; Ahmadiani, A.
Horm. Behav.
51
605-610
Long-term treatment with morphine increases the D-serine content in the rat brain by regulating the mRNA and protein expressions of serine racemase and D-amino acid oxidase
2008
Yoshikawa, M.; Shinomiya, T.; Takayasu, N.; Tsukamoto, H.; Kawaguchi, M.; Kobayashi, H.; Oka, T.; Hashimoto, A.
J. Pharmacol. Sci.
107
270-276
Recent advances in the in silico modelling of UDP glucuronosyltransferase substrates
2008
Sorich, M.J.; Smith, P.A.; Miners, J.O.; Mackenzie, P.I.; McKinnon, R.A.
Curr. Drug Metab.
9
60-69
The UDP-glucuronosyltransferase 2B7 isozyme is responsible for gemfibrozil glucuronidation in the human liver
2007
Mano, Y.; Usui, T.; Kamimura, H.
Drug Metab. Dispos.
35
2040-2044
Species differences in UDP-glucuronosyltransferase activities in mice and rats
2008
Shiratani, H.; Katoh, M.; Nakajima, M.; Yokoi, T.
Drug Metab. Dispos.
36
1745-1752
Contribution of UDP-glucuronosyltransferase 1A1 and 1A8 to morphine-6-glucuronidation and its kinetic properties
2008
Ohno, S.; Kawana, K.; Nakajin, S.
Drug Metab. Dispos.
36
688-694
Endogenous regulators of G protein signaling differentially modulate full and partial mu-opioid agonists at adenylyl cyclase as predicted by a collision coupling model
2008
Clark, M.J.; Linderman, J.J.; Traynor, J.R.
Mol. Pharmacol.
73
1538-1548
Effects of some analgesic anaesthetic drugs on human erythrocyte glutathione reductase: an in vitro study
2009
Senturk, M.; Irfan Kufrevioglu, O.; Ciftci, M.
J. Enzyme Inhib. Med. Chem.
24
420-424
Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the "switch" to opiate addiction
2008
Espinosa, V.P.; Liu, Y.; Ferrini, M.; Anghel, A.; Nie, Y.; Tripathi, P.V.; Porche, R.; Jansen, E.; Stuart, R.C.; Nillni, E.A.; Lutfy, K.; Friedman, T.C.
Neuroscience
156
788-799
Molecular cloning of the baboon UDP-glucuronosyltransferase 2B gene family and their activity in conjugating morphine
2010
Abildskov, K.; Weldy, P.; Garland, M.
Drug Metab. Dispos.
38
545-553
Mechanisms involved in phosphatidylinositol 3-kinase pathway mediated up-regulation of the mu opioid receptor in lymphocytes
2010
Liu, H.; Li, H.; Guo, L.; Li, M.; Li, C.; Wang, S.; Jiang, W.; Liu, X.; McNutt, M.A.; Li, G.
Biochem. Pharmacol.
79
516-523
5alpha-reductase 1 regulates spinal cord testosterone after morphine administration
2013
Sharif, A.; Shoae-Hassani, A.; Sharif, S.; Banafshe, H.R.; Mortazavi-Tabatabaei, S.A.; Verdi, J.
Neurol. Sci.
34
19-23
Hepatic microsomal UDP-glucuronosyltransferase (UGT) activities in the microminipig
2014
Higashi, E.; Ando, A.; Iwano, S.; Murayama, N.; Yamazaki, H.; Miyamoto, Y.
Biopharm. Drug Dispos.
35
313-320
Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies
2014
Chau, N.; Elliot, D.J.; Lewis, B.C.; Burns, K.; Johnston, M.R.; Mackenzie, P.I.; Miners, J.O.
J. Pharmacol. Exp. Ther.
349
126-137
-
A highly selective probe for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human microsomes: Isoform specificity, kinetic characterization, and applications
2015
Tian, X.; Wang, C.; Ge, G.; Ning, J.; Ai, C.; Hong, J.; Cai, Y.; Huo, X.; Hou, J.; Liu, K.; Sun, H.; Ma, X.
RSC Adv.
5
5924-5927
Characterization of rabbit morphine 6-dehydrogenase and two NAD+-dependent 3alpha(17beta)-hydroxysteroid dehydrogenases
2013
Endo, S.; Matsunaga, T.; Fujimoto, A.; Kumada, S.; Arai, Y.; Miura, Y.; Mikamo, H.; El-Kabbani, O.; Yamano, S.; Iinuma, M.; Hara, A.
Arch. Biochem. Biophys.
529
131-139
Characterization of hamster NAD+-dependent 3(17)beta-hydroxysteroid dehydrogenase belonging to the aldo-keto reductase 1C subfamily
2015
Endo, S.; Noda, M.; Ikari, A.; Tatematsu, K.; El-Kabbani, O.; Hara, A.; Kitade, Y.; Matsunaga, T.
J. Biochem.
158
425-434
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance A review of the past decade
2016
Chen, Z.; Shi, T.; Zhang, L.; Zhu, P.; Deng, M.; Huang, C.; Hu, T.; Jiang, L.; Li, J.
Cancer Lett.
370
153-164
Functional and molecular characterization of UDP-glucuronosyltransferase 2 family in cynomolgus macaques
2019
Uno, Y.; Takahira, R.; Murayama, N.; Onozeki, S.; Kawamura, S.; Uehara, S.; Ikenaka, Y.; Ishizuka, M.; Ikushiro, S.; Yamazaki, H.
Biochem. Pharmacol.
163
335-344
Oligomerization and catalytic parameters of human UDP-glucuronosyltransferase 1A10 expression and characterization of the recombinant protein
2018
Kim, K.; Zheng, F.; Zhan, C.G.
Drug Metab. Dispos.
46
1446-1452
Age-dependent hepatic UDP-glucuronosyltransferase gene expression and activity in children
2016
Neumann, E.; Mehboob, H.; Ramírez, J.; Mirkov, S.; Zhang, M.; Liu, W.
Front. Pharmacol.
7
437
Comprehensive Characterization of mouse UDP-glucuronosyltransferase (Ugt) belonging to the Ugt2b subfamily identification of Ugt2b36 as the predominant isoform involved in morphine glucuronidation
2017
Kurita, A.; Miyauchi, Y.; Ikushiro, S.; Mackenzie, P.I.; Yamada, H.; Ishii, Y.
J. Pharmacol. Exp. Ther.
361
199-208
Hypothesis Metabolic targeting of 5-aminolevulinate synthase by tryptophan and inhibitors of heme utilisation by tryptophan 2,3-dioxygenase as potential therapies of acute hepatic porphyrias
2019
Badawy, A.A.
Med. Hypotheses
131
109314
Effects of human SULT1A3/SULT1A4 genetic polymorphisms on the sulfation of acetaminophen and opioid drugs by the cytosolic sulfotransferase SULT1A3
2018
Bairam, A.F.; Rasool, M.I.; Alherz, F.A.; Abunnaja, M.S.; El Daibani, A.A.; Kurogi, K.; Liu, M.C.
Arch. Biochem. Biophys.
648
44-52
Morphine binds creatine kinase B and inhibits its activity
2018
Weinsanto, I.; Mouheiche, J.; Laux-Biehlmann, A.; Delalande, F.; Marquette, A.; Chavant, V.; Gabel, F.; Cianferani, S.; Charlet, A.; Parat, M.O.; Goumon, Y.
Front. Cell. Neurosci.
12
464
Codeinone reductase isoforms with differential stability, efficiency and product selectivity in opium poppy
2018
Dastmalchi, M.; Chang, L.; Torres, M.; Ng, K.; Facchini, P.
Plant J.
95
631-647
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