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EC 2.4.1.101 Details
EC number
2.4.1.101
Accepted name
α-1,3-mannosyl-glycoprotein 2-β-N-acetylglucosaminyltransferase
Reaction
UDP-N-acetyl-α-D-glucosamine + Man5GlcNAc2-[protein] = UDP + Man5GlcNAc3-[protein]
Other name(s)
MGAT1 (gene name), N-acetylglucosaminyltransferase I, N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I, uridine diphosphoacetylglucosamine-α-1,3-mannosylglycoprotein β-1,2-N-acetylglucosaminyltransferase, UDP-N-acetylglucosaminyl:α-1,3-D-mannoside-β-1,2-N-acetylglucosaminyltransferase I, UDP-N-acetylglucosaminyl:α-3-D-mannoside β-1,2-N-acetylglucosaminyltransferase I, α-1,3-mannosyl-glycoprotein β-1,2-N-acetylglucosaminyltransferase, GnTI, GlcNAc-T I, UDP-N-acetyl-D-glucosamine:3-(α-D-mannosyl)-β-D-mannosyl-glycoprotein 2-β-N-acetyl-D-glucosaminyltransferase
Systematic name
UDP-N-acetyl-α-D-glucosamine:α-D-mannosyl-(1→3)-β-D-mannosyl-glycoprotein 2-β-N-acetyl-D-glucosaminyltransferase (configuration-inverting)
CAS registry number
102576-81-8
Comment
The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus. Its action is required before the other N-acetylglucosaminyltransferases involved in the process (GlcNAcT-II through VI) can act. While the natural substrate (produced by EC 3.2.1.113, mannosyl-oligosaccharide 1,2-α-mannosidase) is described here, the minimal substrate recognized by the enzyme is α-D-Man-(1→3)-β-D-Man-R.
History
created 1983, modified 2001 (EC 2.4.1.51 created 1972, part incorporated 1984), modified 2018
EC Tree
2.4.1.3 created 1961, deleted 1972
2.4.1.6 created 1961, deleted 1972
2.4.1.42 created 1972, deleted 1984
2.4.1.51 created 1972, deleted 1984
2.4.1.55 created 1972, deleted 1982
2.4.1.59 created 1972, deleted 1984
2.4.1.61 created 1972, deleted 1984
2.4.1.72 created 1972, deleted 1976
2.4.1.75 created 1976, deleted 2005
2.4.1.76 created 1976, deleted 1984
2.4.1.77 created 1976, deleted 1984
2.4.1.84 created 1976, deleted 1984
2.4.1.89 created 1976, deleted 1984
2.4.1.93 created 1976, deleted 2004
2.4.1.98 created 1980, deleted 1984
2.4.1.107 created 1983, deleted 1984
2.4.1.108 created 1983, deleted 1984
2.4.1.124 created 1984, deleted 2002
2.4.1.151 created 1984, deleted 2002
2.4.1.169 created 1989, deleted 2003
2.4.1.200 created 1992, deleted 2004
2.4.1.204 created 1992, deleted 2003
2.4.1.233 created 2004, deleted 2005