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EC 2.4.1.65 Details
EC number
2.4.1.65
Accepted name
3-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase
Reaction
GDP-β-L-fucose + β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-R = GDP + β-D-galactosyl-(1→3)-[α-L-fucosyl-(1→4)]-N-acetyl-β-D-glucosaminyl-R
Other name(s)
(Lea)-dependent (α-3/4)-fucosyltransferase, α(1,3/1,4) fucosyltransferase III, α-(1→4)-L-fucosyltransferase, α-4-L-fucosyltransferase, β-acetylglucosaminylsaccharide fucosyltransferase, FucT-II, Lewis α-(1→3/4)-fucosyltransferase, Lewis blood group α-(1→3/4)-fucosyltransferase, Lewis(Le) blood group gene-dependent α-(1→3/4)-L-fucosyltransferase, blood group Lewis α-4-fucosyltransferase, blood-group substance Lea-dependent fucosyltransferase, guanosine diphosphofucose-β-acetylglucosaminylsaccharide 4-α-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-α-L-fucosyltransferase, guanosine diphosphofucose-glycoprotein 4-α-fucosyltransferase, 3-α-galactosyl-N-acetylglucosaminide 4-α-L-fucosyltransferase, GDP-β-L-fucose:3-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-α-L-fucosyltransferase, GDP-L-fucose:3-β-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-α-L-fucosyltransferase
Systematic name
GDP-β-L-fucose:β-D-galactosyl-(1→3)-N-acetyl-β-D-glucosaminyl-R 4I-α-L-fucosyltransferase (configuration-inverting)
CAS registry number
37277-69-3
Comment
This enzyme is the product of the Lewis blood group gene. Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. Although it is a 4-fucosyltransferase, it has a persistent 3-fucosyltransferase activity towards the glucose residue in free lactose. This enzyme fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3, unlike EC 2.4.1.152, 4-galactosyl-N-acetylglucosaminide 3-α-L-fucosyltransferase, which fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4. Enzymes catalysing the 4-α-fucosylation of the GlcNAc in β-D-Gal-(1→3)-β-GlcNAc sequences (with some activity also as 3-α-fucosyltransferases) are present in plants, where the function in vivo is the modification of N-glycans. In addition, the fucTa gene of Helicobacter strain UA948 encodes a fucosyltransferase with both 3-α- and 4-α-fucosyltransferase activities.
History
created 1972, modified 2001, modified twice 2002
EC Tree
2.4.1.3 created 1961, deleted 1972
2.4.1.6 created 1961, deleted 1972
2.4.1.42 created 1972, deleted 1984
2.4.1.51 created 1972, deleted 1984
2.4.1.55 created 1972, deleted 1982
2.4.1.59 created 1972, deleted 1984
2.4.1.61 created 1972, deleted 1984
2.4.1.72 created 1972, deleted 1976
2.4.1.75 created 1976, deleted 2005
2.4.1.76 created 1976, deleted 1984
2.4.1.77 created 1976, deleted 1984
2.4.1.84 created 1976, deleted 1984
2.4.1.89 created 1976, deleted 1984
2.4.1.93 created 1976, deleted 2004
2.4.1.98 created 1980, deleted 1984
2.4.1.107 created 1983, deleted 1984
2.4.1.108 created 1983, deleted 1984
2.4.1.124 created 1984, deleted 2002
2.4.1.151 created 1984, deleted 2002
2.4.1.169 created 1989, deleted 2003
2.4.1.200 created 1992, deleted 2004
2.4.1.204 created 1992, deleted 2003
2.4.1.233 created 2004, deleted 2005