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EC 2.4.1.131 Details
EC number
2.4.1.131
Accepted name
GDP-Man:Man3GlcNAc2-PP-dolichol α-1,2-mannosyltransferase
Reaction
2 GDP-α-D-mannose + α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol = 2 GDP + α-D-Man-(1→2)-α-D-Man-(1→2)-α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol
Other name(s)
ALG11, ALG11 mannosyltransferase, LEW3 (gene name), At2G40190 (gene name), gmd3 (gene name), galactomannan deficiency protein 3, GDP-mannose:glycolipid 1,2-α-D-mannosyltransferase, glycolipid 2-α-mannosyltransferase, GDP-mannose:glycolipid 2-α-D-mannosyltransferase, GDP-Man:Man3GlcNAc2-PP-Dol α-1,2-mannosyltransferase, GDP-α-D-mannose:D-Man-α-(1→3)-[D-Man-α-(1→6)]-D-Man-β-(1→4)-D-GlcNAc-β-(1→4)-D-GlcNAc-diphosphodolichol 2-α-D-mannosyltransferase
Systematic name
GDP-α-D-mannose:α-D-Man-(1→3)-[α-D-Man-(1→6)]-β-D-Man-(1→4)-β-D-GlcNAc-(1→4)-α-D-GlcNAc-diphosphodolichol 2-α-D-mannosyltransferase (configuration-retaining)
CAS registry number
74506-43-7
Comment
The biosynthesis of asparagine-linked glycoproteins (N-linked protein glycosylation) utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway. ALG11 mannosyltransferase from Saccharomyces cerevisiae carries out two sequential steps in the formation of the lipid-linked core oligosaccharide, adding two mannose residues in α(1→2) linkages to the nascent oligosaccharide.
History
created 1984, modified 2011, modified 2012
EC Tree
2.4.1.3 created 1961, deleted 1972
2.4.1.6 created 1961, deleted 1972
2.4.1.42 created 1972, deleted 1984
2.4.1.51 created 1972, deleted 1984
2.4.1.55 created 1972, deleted 1982
2.4.1.59 created 1972, deleted 1984
2.4.1.61 created 1972, deleted 1984
2.4.1.72 created 1972, deleted 1976
2.4.1.75 created 1976, deleted 2005
2.4.1.76 created 1976, deleted 1984
2.4.1.77 created 1976, deleted 1984
2.4.1.84 created 1976, deleted 1984
2.4.1.89 created 1976, deleted 1984
2.4.1.93 created 1976, deleted 2004
2.4.1.98 created 1980, deleted 1984
2.4.1.107 created 1983, deleted 1984
2.4.1.108 created 1983, deleted 1984
2.4.1.124 created 1984, deleted 2002
2.4.1.151 created 1984, deleted 2002
2.4.1.169 created 1989, deleted 2003
2.4.1.200 created 1992, deleted 2004
2.4.1.204 created 1992, deleted 2003
2.4.1.233 created 2004, deleted 2005