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Information on EC 2.4.1.152 - 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

for references in articles please use BRENDA:EC2.4.1.152
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IUBMB Comments
Normally acts on a glycoconjugate where R (see reaction) is a glycoprotein or glycolipid. This enzyme fucosylates on O-3 of an N-acetylglucosamine that carries a galactosyl group on O-4, unlike EC 2.4.1.65, 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase, which fucosylates on O-4 of an N-acetylglucosamine that carries a galactosyl group on O-3.
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Word Map
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
fuc-tv, alpha-3-fucosyltransferase, alpha-3-l-fucosyltransferase, alpha1,3 fuct-vii, fut vi, alpha1,3ft, alpha1,3-fuct, fucosyltransferase-vii, fucosyltransferase ix, fuctvii, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
GDP-beta-L-fucose + (1->4)-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + (1->4)-beta-D-galactosyl-[alpha-(1->3)-L-fucosyl]-N-acetyl-D-glucosaminyl-R
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i.e. Lewis X determinent
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