3.1.6.14: N-acetylglucosamine-6-sulfatase
This is an abbreviated version!
For detailed information about N-acetylglucosamine-6-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.14
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3.1.6.14
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proteoglycans
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sulfatases
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6-o-sulfation
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sulf-2
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mucopolysaccharidosis
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arylsulfatase
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sanfilippo
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medicine
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hspgs
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trisulfated
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naglu
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hgsnat
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sulfamidase
- 3.1.6.14
- proteoglycans
-
sulfatases
-
6-o-sulfation
-
sulf-2
- mucopolysaccharidosis
- arylsulfatase
-
sanfilippo
- medicine
-
hspgs
-
trisulfated
- naglu
- hgsnat
-
sulfamidase
Reaction
Synonyms
2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase, 6-O-sulfatase, acetylglucosamine 6-sulfatase, chondroitinsulfatase, G6S, glucosamine 6-O-sulfatase, glucosamine-6-sulfatase, glucosamine-6-sulfate sulfatase, heparan sulfate 6-O-endosulfatase, heparan sulfate 6-O-endosulfatase1, heparin/heparan sulfate 6-O-sulfatase, HS 6-O-endosulfatase, HSGAG sulfatase, N-acetylglucosamine 6-sulfate sulfatase, N-acetylglucosamine-6-sulfatase, NG6S, O,N-disulfid O-sulfohydrolase, Sulf-1, sulfatase, acetylglucosamine 6-
ECTree
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Engineering
Engineering on EC 3.1.6.14 - N-acetylglucosamine-6-sulfatase
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D186A
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53% relative activity after 0.5 h and 92% relative activity after 5 h compared to the wild type enzyme
additional information
mutation of glutamine 390 to stop-codon causes Mucopolysaccharidosis type IIID
additional information
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mutation of glutamine 390 to stop-codon causes Mucopolysaccharidosis type IIID
additional information
silencing the expression of Sulf-1 by RNA interference restores the responses induced by FGF-1, which indicates that TNF-alpha-mediated induction of the sulfatase results in alterations of HS biological properties
additional information
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silencing the expression of Sulf-1 by RNA interference restores the responses induced by FGF-1, which indicates that TNF-alpha-mediated induction of the sulfatase results in alterations of HS biological properties