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3.1.6.14: N-acetylglucosamine-6-sulfatase

This is an abbreviated version!
For detailed information about N-acetylglucosamine-6-sulfatase, go to the full flat file.

Word Map on EC 3.1.6.14

Reaction

D-GlcNAc-6-sulfate
+
H2O
=
D-GlcNAc
 +
sulfate

Synonyms

2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase, 6-O-sulfatase, acetylglucosamine 6-sulfatase, chondroitinsulfatase, G6S, glucosamine 6-O-sulfatase, glucosamine-6-sulfatase, glucosamine-6-sulfate sulfatase, heparan sulfate 6-O-endosulfatase, heparan sulfate 6-O-endosulfatase1, heparin/heparan sulfate 6-O-sulfatase, HS 6-O-endosulfatase, HSGAG sulfatase, N-acetylglucosamine 6-sulfate sulfatase, N-acetylglucosamine-6-sulfatase, NG6S, O,N-disulfid O-sulfohydrolase, Sulf-1, sulfatase, acetylglucosamine 6-

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.14 N-acetylglucosamine-6-sulfatase

Reference

topprint

Reference on EC 3.1.6.14 - N-acetylglucosamine-6-sulfatase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Freeman, C.; Clements, P.R.; Hopwood, J.J.
Human liver N-acetylglucosamine-6-sulphate sulphatase. Purification and characterization
Biochem. J.
246
347-354
1987
Homo sapiens
Manually annotated by BRENDA team
Freeman, C.; Hopwood, J.J.
Human liver N-acetylglucosamine-6-sulphate sulphatase. Catalytic properties
Biochem. J.
246
355-365
1987
Bos taurus, Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Basner, R.; Kresse, H.; von Figura, K.
N-Acetylglucosamine-6-sulfate sulfatase from human urine
J. Biol. Chem.
254
1151-1158
1979
Homo sapiens
Manually annotated by BRENDA team
Elliott, H.; Hopwood, J.J.
Detection of the Sanfilippo D syndrome by the use of a radiolabeled monosaccharide sulfate as the substrate for the estimation of N-acetylglucosamine-6-sulfate sulfatase
Anal. Biochem.
138
205-209
1984
Homo sapiens
Manually annotated by BRENDA team
Di Ferrante, N.
N-acetylglucosamine-6-sulfate sulfatase deficiency reconsidered
Science
210
448
1980
Homo sapiens
Manually annotated by BRENDA team
Kresse, H.; Fuchs, W.; Glossl, J.; Holtfrerich, D.; Gilberg, W.
Liberation of N-acetylglucosamine-6-sulfate by human beta-N-acetylhexosaminidase A
J. Biol. Chem.
256
12926-12932
1981
Homo sapiens
Manually annotated by BRENDA team
Kresse, H.; von Figura, K.; Klein, U.; Glossl, J.; Paschke, E.; Pohlmann, R.
Enzymic diagnosis of the genetic mucopolysaccharide storage disorders
Methods Enzymol.
83
559-572
1982
Homo sapiens
Manually annotated by BRENDA team
Freeman, C.; Hopwood, J.J.
Sanfilippo D syndrome: estimation of N-acetylglucosamine-6-sulfatase activity with a radiolabeled monosulfated disaccharide substrate
Anal. Biochem.
176
244-248
1989
Homo sapiens
Manually annotated by BRENDA team
Kresse, H.; Paschke, E.; von Figura, K.; Gilberg, W.; Fuchs, W.
Sanfilippo disease type D: deficiency of N-acetylglucosamine-6-sulfate sulfatase required for heparan sulfate degradation
Proc. Natl. Acad. Sci. USA
77
6822-6826
1980
Homo sapiens
Manually annotated by BRENDA team
Thompson, J.N.; Jones, M.Z.; Dawson, G.; Huffman, P.S.
N-Acetylglucosamine 6-sulphatase deficiency in a Nubian goat: a model of Sanfilippo syndrome type D (mucopolysaccharidosis IIID)
J. Inherit. Metab. Dis.
15
760-768
1992
Capra hircus
Manually annotated by BRENDA team
Robertson, D.A.; Freeman, C.; Morris, C.P.; Hopwood, J.J.
A cDNA clone for human glucosamine-6-sulphatase reveals differences between arylsulphatases and non-arylsulphatases
Biochem. J.
288
539-544
1992
Homo sapiens
Manually annotated by BRENDA team
Freeman, C.; Hopwood, J.J.
Human glucosamine-6-sulphatase deficiency. Diagnostic enzymology towards heparin-derived trisaccharide substrates
Biochem. J.
282
605-614
1992
Homo sapiens
Manually annotated by BRENDA team
Shilatifard, A.; Cummings, R.D.
Purification and characterization of N-acetylglucosamine-6-sulfate sulfatase from bovine kidney: evidence for the presence of a novel endosulfatase activity
Biochemistry
33
4273-4282
1994
Bos taurus
Manually annotated by BRENDA team
Medeiros, M.G.; Ferreira, T.M.; Leite, E.L.; Toma, L.; Dietrich, C.P.; Nader, H.B.
New pathway of heparan sulphate degradation. Iduronate sulphatase and N-sulphoglucosamine 6-sulphatase act on the polymer chain prior to depolymerisation by a N-sulpho-glucosaminidase and glycuronidases in the mollusc Tagelus gibbus
Comp. Biochem. Physiol. B
119
539-547
1998
Tagelus gibbus
Manually annotated by BRENDA team
Sleat, D.E.; Kraus, S.R.; Sohar, I.; Lackland, H.; Lobel, P.
alpha-Glucosidase and N-acetylglucosamine-6-sulphatase are the major mannose-6-phosphate glycoproteins in human urine
Biochem. J.
324
33-39
1997
Homo sapiens
Manually annotated by BRENDA team
Litjens, T.; Bielicki, J.; Anson, D.S.; Friderici, K.; Jones, M.Z.; Hopwood, J.J.
Expression, purification and characterization of recombinant caprine N-acetylglucosamine-6-sulphatase
Biochem. J.
327
89-94
1997
Capra hircus
Manually annotated by BRENDA team
Wright, D.P.; Rosendale, D.I.; Robertson, A.M.
Prevotella enzymes involved in mucin oligosaccharide degradation and evidence for a small operon of genes expressed during growth on mucin
FEMS Microbiol. Lett.
190
73-79
2000
Prevotella sp., Prevotella sp. RS2
Manually annotated by BRENDA team
Beesley, C.E.; Burke, D.; Jackson, M.; Vellodi, A.; Winchester, B.G.; Young, E.P.
Sanfilippo syndrome type D: identification of the first mutation in the N-acetylglucosamine-6-sulphatase gene
J. Med. Genet.
40
192-194
2003
Homo sapiens
Manually annotated by BRENDA team
Xu, S.; Zhao, L.; Larsson, A.; Smeds, E.; Kusche-Gullberg, M.; Venge, P.
Purification of a 75 kDa protein from the organelle matrix of human neutrophils and identification as N-acetylglucosamine-6-sulphatase
Biochem. J.
387
841-847
2005
Homo sapiens
Manually annotated by BRENDA team
Jansen, A.C.; Cao, H.; Kaplan, P.; Silver, K.; Leonard, G.; De Meirleir, L.; Lissens, W.; Liebaers, I.; Veilleux, M.; Andermann, F.; Hegele, R.A.; Andermann, E.
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene
Arch. Neurol.
64
1629-1634
2007
Homo sapiens (P15586), Homo sapiens
Manually annotated by BRENDA team
Myette, J.R.; Soundararajan, V.; Shriver, Z.; Raman, R.; Sasisekharan, R.
Heparin/heparan sulfate 6-O-sulfatase from Flavobacterium heparinum: integrated structural and biochemical investigation of enzyme active site and substrate specificity
J. Biol. Chem.
284
35177-35188
2009
Pedobacter heparinus
Manually annotated by BRENDA team
Zhou, X.; Li, L.; Linhardt, R.J.; Liu, J.
Neutralizing the anticoagulant activity of ultra-low-molecular-weight heparins using N-acetylglucosamine 6-sulfatase
FEBS J.
280
2523-2532
2013
Homo sapiens
Manually annotated by BRENDA team
Sikora, A.-S.; Hellec, C.; Carpentier, M.; Martinez, P.; Delos, M.; Denys, A.; Allain, F.
Tumour-necrosis factor-alpha induces heparan sulfate 6-O-endosulfatase1 (Sulf-1) expression in fibroblasts
Int. J. Biochem. Cell Biol.
80
57-65
2016
Homo sapiens (P15586), Homo sapiens
Manually annotated by BRENDA team