2.5.1.39: 4-hydroxybenzoate polyprenyltransferase This is an abbreviated version! For detailed information about 4-hydroxybenzoate polyprenyltransferase, go to the full flat file .
Word Map on EC 2.5.1.39
Reaction
a polyprenyl diphosphate +
4-hydroxybenzoate =
diphosphate +
a 4-hydroxy-3-polyprenylbenzoate
Synonyms 4-hydroxybenzoate octaprenyl transferase, 4-hydroxybenzoate octaprenyltransferase, 4-hydroxybenzoate polyprenyl diphosphate transferase, 4-hydroxybenzoate transferase, 4-hydroxybenzoate:polyprenyl transferase, 4-hydroxybenzoic acid oligoprenyltransferase, 4-para-hydroxybenzoate:polyprenyl transferase, 4-parahydroxybenzoate: polyprenyl transferase, 4HPT, COQ2, Coq2p, dimethylallyltransferase, p-hydroxybenzoate poly-, nonaprenyl-4-hydroxybenzoate transferase, NPHB transferase, OH-benzoate polyprenyltransferase, ORF3, OsPPT1a, p-hydroxybenzoate dimethylallyltransferase, p-hydroxybenzoate polyprenyltransferase, p-hydroxybenzoate:octaprenyltransferase, p-hydroxybenzoate:polyprenyl transferase, p-hydroxybenzoate:polyprenyltransferase, p-hydroxybenzoic acid-polyprenyl transferase, p-hydroxybenzoic-polyprenyl transferase, para-hydroxybenzoate-polyprenyl transferase, PHB-polyprenyltransferase, polyprenyl 4-hydroxybenzoate transferase, PPT, SmPPT, ubiA
ECTree
Localization
Localization on EC 2.5.1.39 - 4-hydroxybenzoate polyprenyltransferase
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low activity
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low activity
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Golgi III vesicles, high specific activity, associated with inner luminal surface of microsomal vesicles
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additional information
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at low levels: rough and smooth I microsomes, mitochondria, not: peroxisomes, cytosol
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the enzyme has nine transmembrane helices and an extramembrane cap domain that surround a large central cavity containing the active site. To facilitate the catalysis inside membranes, UbiA has an unusual active site that opens laterally to the lipid bilayer
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the enzyme has nine transmembrane helices and an extramembrane cap domain that surround a large central cavity containing the active site. To facilitate the catalysis inside membranes, UbiA has an unusual active site that opens laterally to the lipid bilayer
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membrane-bound protein
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the enzyme contains 6 transmembrane sequences
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smooth II microsome, high specific activity, associated with inner luminal surface of microsomal vesicles
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enzymatic activity is almost doubled in microsomes prepared from nodular tissues
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highest activity
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enzyme contains an N-terminal mitochondrial targeting sequence
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low activity
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activity mainly detected in mitochondria
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enzyme contains a mitochondrion targeting sequence
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mainly localized in the mitochondria
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low activity
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