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Information on EC 2.5.1.39 - 4-hydroxybenzoate polyprenyltransferase

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IUBMB Comments
This enzyme, involved in the biosynthesis of ubiquinone, attaches a polyprenyl side chain to a 4-hydroxybenzoate ring, producing the first ubiquinone intermediate that is membrane bound. The number of isoprenoid subunits in the side chain varies in different species. The enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency [2,4,5].
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Word Map
The expected taxonomic range for this enzyme is: Archaea, Bacteria, Eukaryota
Synonyms
osppt1a, coq2p, 4-hydroxybenzoate octaprenyltransferase, nonaprenyl-4-hydroxybenzoate transferase, 4-hydroxybenzoate:polyprenyl transferase, p-hydroxybenzoate:polyprenyltransferase, para-hydroxybenzoate-polyprenyl transferase, 4-hydroxybenzoate transferase, p-hydroxybenzoate polyprenyltransferase, oh-benzoate polyprenyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a polyprenyl diphosphate + 4-hydroxybenzoate = diphosphate + a 4-hydroxy-3-polyprenylbenzoate
show the reaction diagram
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