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Literature summary for 2.5.1.39 extracted from

  • Forsman, U.; Sjoeberg, M.; Turunen, M.; Sindelar, P.J.
    4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures (2010), Nat. Chem. Biol., 6, 515-517.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-nitrobenzoate competitive enzyme inhibition, cell treatement with 4-nitrobenzoate leads to a decrease in coenzyme Q content, but 4-nitrobenzoate treatment has no apparent toxic effect on the cells and does not decrease Q concentration by inducing oxidative stress Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
Mus musculus 31966
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a polyprenyl diphosphate + 4-hydroxybenzoate Mus musculus
-
diphosphate + a 4-hydroxy-3-polyprenylbenzoate
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
gene COQ2
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Mus musculus
-
Swiss-3T3 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a polyprenyl diphosphate + 4-hydroxybenzoate
-
Mus musculus diphosphate + a 4-hydroxy-3-polyprenylbenzoate
-
?
a polyprenyl diphosphate + 4-hydroxybenzoate Coq2 is quite unspecific with regard to its substrates Mus musculus diphosphate + a 4-hydroxy-3-polyprenylbenzoate
-
?
geranyl diphosphate + 4-hydroxybenzoate
-
Mus musculus diphosphate + 3-geranyl-4-hydroxybenzoate
-
?

Synonyms

Synonyms Comment Organism
4-hydroxybenzoate:polyprenyl transferase
-
Mus musculus
COQ2
-
Mus musculus

General Information

General Information Comment Organism
physiological function Coq2 plays an important role in coenzyme Q metabolism Mus musculus