2.3.1.226: carboxymethylproline synthase
This is an abbreviated version!
For detailed information about carboxymethylproline synthase, go to the full flat file.
Word Map on EC 2.3.1.226
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2.3.1.226
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crotonase
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functionalised
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methylmalonyl-coa
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carbapenams
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beta-lactams
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synthesis
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carboxylase
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biocatalysis
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cyclization
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synthases
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bicyclic
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malonyl-coenzyme
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acetyl-coa
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crotonyl-coa
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simplest
-
stereoselective
-
medicine
- 2.3.1.226
- crotonase
-
functionalised
- methylmalonyl-coa
-
carbapenams
- beta-lactams
- synthesis
- carboxylase
-
biocatalysis
-
cyclization
- synthases
-
bicyclic
-
malonyl-coenzyme
- acetyl-coa
- crotonyl-coa
-
simplest
-
stereoselective
- medicine
Reaction
Synonyms
CarB
ECTree
Advanced search results
Reference
Reference on EC 2.3.1.226 - carboxymethylproline synthase
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Batchelar, E.T.; Hamed, R.B.; Ducho, C.; Claridge, T.D.; Edelmann, M.J.; Kessler, B.; Schofield, C.J.
Thioester hydrolysis and C-C bond formation by carboxymethylproline synthase from the crotonase superfamily
Angew. Chem. Int. Ed. Engl.
47
9322-93225
2008
Pectobacterium carotovorum
Gerratana, B.; Arnett, S.O.; Stapon, A.; Townsend, C.A.
Carboxymethylproline synthase from Pectobacterium carotorova: a multifaceted member of the crotonase superfamily
Biochemistry
43
15936-15945
2004
Pectobacterium carotovorum
Hamed, R.B.; Mecinovic, J.; Ducho, C.; Claridge, T.D.; Schofield. C.J.
Carboxymethylproline synthase catalysed syntheses of functionalised N-heterocycles
Chem. Commun. (Camb. )
46
1413-1415
2010
Pectobacterium carotovorum
Sorensen, J.L.; Sleeman, M.C.; Schofield, C.J.
Synthesis of deuterium labelled L- and D-glutamate semialdehydes and their evaluation as substrates for carboxymethylproline synthase (CarB) - implications for carbapenem biosynthesis
Chem. Commun. (Camb. )
7
1155-1157
2005
Pectobacterium carotovorum
Sleeman, M.C.; Schofield, C.J.
Carboxymethylproline synthase (CarB), an unusual carbon-carbon bond-forming enzyme of the crotonase superfamily involved in carbapenem biosynthesis
J. Biol. Chem.
279
6730-6736
2004
Pectobacterium carotovorum
Sleeman, M.C.; Sorensen, J.L.; Batchelar, E.T.; McDonough, M.A.; Schofield, C.J.
Structural and mechanistic studies on carboxymethylproline synthase (CarB), a unique member of the crotonase superfamily catalyzing the first step in carbapenem biosynthesis
J. Biol. Chem.
280
34956-34965
2005
Pectobacterium carotovorum (Q9XB60)
McGowan, S.J.; Sebaihia, M.; Porter, L.E.; Stewart, G.S.; Williams, P.; Bycroft, B.W.; Salmond, G.P.
Analysis of bacterial carbapenem antibiotic production genes reveals a novel beta-lactam biosynthesis pathway
Mol. Microbiol.
22
415-426
1996
Pectobacterium carotovorum, Pectobacterium carotovorum GS101
Hamed, R.B.; Gomez-Castellanos, J.R.; Thalhammer, A.; Harding, D.; Ducho, C.; Claridge, T.D.; Schofield. C.J.
Stereoselective C-C bond formation catalysed by engineered carboxymethylproline synthases
Nat. Chem.
3
365-371
2011
Pectobacterium carotovorum
Hamed, R.B.; Gomez-Castellanos, J.R.; Froese, D.S.; Krysztofinska, E.; Yue, W.W.; Schofield, C.J.
Use of methylmalonyl-CoA epimerase in enhancing crotonase stereoselectivity
ChemBioChem
17
1-7
2015
Pectobacterium carotovorum (Q9XB60)
Hamed, R.B.; Gomez-Castellanos, J.R.; Henry, L.; Warhaut, S.; Claridge, T.D.W.; Schofield, C.J.
Biocatalytic production of bicyclic ?-lactams with three contiguous chiral centres using engineered crotonases
Commun. Chem.
2
7
2019
Pectobacterium carotovorum subsp. carotovorum (Q9XB60)
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