2.1.1.370: [histone H3]-lysine4 N-dimethyltransferase
This is an abbreviated version!
For detailed information about [histone H3]-lysine4 N-dimethyltransferase, go to the full flat file.
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
MEL, NSD3, PFM13, PRDM16, WHISTLE, WHSC1L1
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.370 - [histone H3]-lysine4 N-dimethyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + a [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine4
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S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine4
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?
S-adenosyl-L-methionine + [histone H3]-L-lysine4
S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine4
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-
-
?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine4
S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine4
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?
?
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Nsd3 is specific for the histones H3K4 and H3K27 residues
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additional information
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PRDM16 is able to mono- and di-methylate H3K4 in nucleosomes. No tri-methylation of H3K4 or methylation of other lysine residues of H3 is detected
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