Application | Comment | Organism |
---|---|---|
medicine | Nsd3 expression is increased in both acute myelogenous leukemia (AML) and acute lymphocytic leukemia (ALL) patients | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-adenosyl-L-methionine + [histone H3]-L-lysine4 | Homo sapiens | - |
S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine4 | - |
? | |
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine4 | Homo sapiens | - |
S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine4 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BZ95 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Nsd3 is specific for the histones H3K4 and H3K27 residues | Homo sapiens | ? | - |
- |
|
S-adenosyl-L-methionine + [histone H3]-L-lysine4 | - |
Homo sapiens | S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine4 | - |
? | |
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine4 | - |
Homo sapiens | S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine4 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NSD3 | - |
Homo sapiens |
WHISTLE | - |
Homo sapiens |
WHSC1L1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Nsd3 dimethylates H3K4 and additionally di-, and tri-methylates histones H3K27. Overexpression of Nsd3 represses transcription of the SV40 promoter | Homo sapiens |