2.1.1.370: [histone H3]-lysine4 N-dimethyltransferase
This is an abbreviated version!
For detailed information about [histone H3]-lysine4 N-dimethyltransferase, go to the full flat file.
Reaction
2 S-adenosyl-L-methionine + = 2 S-adenosyl-L-homocysteine +
Synonyms
MEL, NSD3, PFM13, PRDM16, WHISTLE, WHSC1L1
ECTree
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Systematic Name
Systematic Name on EC 2.1.1.370 - [histone H3]-lysine4 N-dimethyltransferase
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S-adenosyl-L-methionine:[histone H3]-L-lysine4 N6-dimethyltransferase
This entry describes enzymes that successively methylate the L-lysine4 residue of histone H3 (H3K4) twice, ultimately generating a dimethylated form. These modifications influence the binding of chromatin-associated proteins. The human NSD3 protein also catalyses the activity of EC 2.1.1.hq, [histone H3]-lysine27 N-dimethyltransferase. cf. EC 2.1.1.364, [histone H3]-lysine4 N-methyltransferase, and EC 2.1.1.354, [histone H3]-lysine4 N-trimethyltransferase.