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2.1.1.370: [histone H3]-lysine4 N-dimethyltransferase

This is an abbreviated version!
For detailed information about [histone H3]-lysine4 N-dimethyltransferase, go to the full flat file.

Reaction

2 S-adenosyl-L-methionine +

a [histone H3]-L-lysine4
= 2 S-adenosyl-L-homocysteine +
a [histone H3]-N6,N6-dimethyl-L-lysine4

Synonyms

MEL, NSD3, PFM13, PRDM16, WHISTLE, WHSC1L1

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.370 [histone H3]-lysine4 N-dimethyltransferase

Application

Application on EC 2.1.1.370 - [histone H3]-lysine4 N-dimethyltransferase

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APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
Nsd3 expression is increased in both acute myelogenous leukemia (AML) and acute lymphocytic leukemia (ALL) patients