1.7.1.14: nitric oxide reductase [NAD(P)+, nitrous oxide-forming]
This is an abbreviated version!
For detailed information about nitric oxide reductase [NAD(P)+, nitrous oxide-forming], go to the full flat file.
Word Map on EC 1.7.1.14
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1.7.1.14
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heme
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oxysporum
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fusarium
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n2o
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denitrifying
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nitrite
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denitrification
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ferric
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dissimilatory
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cylindrocarpon
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tonkinense
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histoplasma
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copper-containing
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capsulatum
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trichosporon
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cutaneum
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p450cam
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nitroxyl
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synthesis
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degradation
- 1.7.1.14
- heme
- oxysporum
- fusarium
- n2o
-
denitrifying
- nitrite
-
denitrification
-
ferric
-
dissimilatory
- cylindrocarpon
- tonkinense
-
histoplasma
-
copper-containing
- capsulatum
-
trichosporon
- cutaneum
-
p450cam
- nitroxyl
- synthesis
- degradation
Reaction
Synonyms
Anor, Cnor1, Cnor2, CYP55A1, CYP55A2, CYP55A3, CYP55A4, CYP55A5, CYP55B1, cytochrome P-450nor, cytochrome P450 55B1, cytochrome P450 NADH-NO reductase, cytochrome P450 nitric oxide reductase, cytochrome P450 NO reductase, cytochrome P450nor, Fnor, fungal nitric oxide reductase, NADPH-dependent cytochrome P450nor, NOR, Nor1, Nor1p, P450 nitric oxide reductase, P450nor, P450nor1, P450nor2, P450norA, P450norB, Tnor
ECTree
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Substrates Products
Substrates Products on EC 1.7.1.14 - nitric oxide reductase [NAD(P)+, nitrous oxide-forming]
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REACTION DIAGRAM
NO + N3-
N2O + ?
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the co-denitrification reaction does not require an electron donor such as NADH
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?
NO + NADP + H+
N2O + NADP+ + H2O
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isozyme P450Nor2 prefers NADPH to NADH
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?
NO + NH4+
N2O + ?
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the co-denitrification reaction does not require an electron donor such as NADH
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?
NO + NADH + H+
N2O + NAD+ + H2O
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isozyme Tnor utilizes both NADH and NADPH as electron donors
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-
?
NO + NADH + H+
N2O + NAD+ + H2O
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isozyme Cnor1 is specific to NADH, while isozyme Cnor2 can use both NADH and NADPH as electron donor
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-
?
NO + NADH + H+
N2O + NAD+ + H2O
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isozyme P450nor1 uses specifically NADH as electron donor, while isozyme P450Nor2 prefers NADPH to NADH
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-
?
NO + NADH + H+
N2O + NAD+ + H2O
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isozyme Fnor utilizes only NADH as electron donor
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?
NO + NADPH + H+
N2O + NADP+ + H2O
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isozyme Cnor2 can use both NADH and NADPH as electron donor
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?
?
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P450nor is a reductase without monooxygenase activity
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?
additional information
?
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P450nor is a reductase without monooxygenase activity
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?
additional information
?
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ammonium is not a direct substrate for P-450nor
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?
additional information
?
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P450nor is a reductase without monooxygenase activity
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?
additional information
?
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P450nor is a reductase without monooxygenase activity
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?
additional information
?
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the enzyme is peculiar in requiring only NADH and no electron transport system for the reduction of NO. NADPH is much less active as the cosubstrate
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?
additional information
?
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quantum chemical and combined quantum mechanics/molecular mechanics clearly favor a direct hydride transfer taking place between the NADH cofactor and NO, where the hydride is shifted to the N of NO. The barriers obtained for the syn, Pro-R conformation of NADH are lower and show significantly less variation than the barriers obtained in the case of anti conformation
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?
additional information
?
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the enzyme is peculiar in requiring only NADH and no electron transport system for the reduction of NO. NADPH is much less active as the cosubstrate
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?
additional information
?
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both oxygen and Nalpha display normal isotope effects during enzymatic NO reduction. Bulk nitrogen and Nbeta exhibit inverse isotope effects. The observed inverse isotope effect in delta15Nbeta is consistent with reversible binding of the first NO in the P450nor reaction mechanism
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?