1.14.14.173: 2,4,6-trichlorophenol monooxygenase

This is an abbreviated version!
For detailed information about 2,4,6-trichlorophenol monooxygenase, go to the full flat file.

Reaction

Synonyms

2,4,6-TCP 4-monooxygenase, 2,4,6-TCP monooxygenase, 2,4,6-trichlorophenol 4-monooxygenase, 2,4,6-trichlorophenol-4-monooxygenase, TCP-4-monooxygenase, tcpA

ECTree

     1 Oxidoreductases

         1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

             1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor

                1.14.14.173 2,4,6-trichlorophenol monooxygenase

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Results	in table
1	Activating Compound
1	AA Sequence
3	Cloned(Commentary)
9	Cofactor
1	Crystallization (Commentary)
3	General Information
1	General Stability
9	Inhibitors
5	Metals/Ions
1	Molecular Weight [Da]
28	Natural Substrates/ Products (Substrates)
17	Organism
3	Pathway
1	pH Optimum
4	Purification (Commentary)
2	Reaction
13	Reference
4	Specific Activity [micromol/min/mg]
3	Storage Stability
70	Substrates and Products (Substrate)
10	Subunits
26	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Range [°C]

Systematic Name

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Systematic Name on EC 1.14.14.173 - 2,4,6-trichlorophenol monooxygenase

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SYSTEMATIC NAME

IUBMB Comments

2,4,6-trichlorophenol,FADH2:oxygen oxidoreductase (dechlorinating)

The enzyme, characterized from a number of bacterial species, participates in the degradation of 2,4,6-trichlorophenol, a compound that has been used for decades as a wood preservative. The enzyme is a multifunctional flavin-dependent monooxygenase that displaces two chlorine atoms by attacking two different positions in the substrate. Each reaction catalysed by the enzyme displaces a single chlorine and results in formation of a dione, which must be reduced by FADH2 before the monooxygenase could catalyse the second reaction. The large amount of FADH2 that is required is generated by a dedicated flavin reductase (TcpB). cf. EC 1.14.14.172, 3,5,6-trichloropyridin-2-ol monooxygenase.