Reference on EC 4.1.3.1 - isocitrate lyase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Robertson, E.F.; Reeves, H.C.
Purification and characterization of isocitrate lyase from Escherichia coli
Curr. Microbiol.
14
347-350
1987
Escherichia coli
-
Mackintosh, C.; Nimmo, H.G.
Purification and properties of Escherichia coli isocitrate lyase
Biochem. Soc. Trans.
14
320-321
1986
Escherichia coli
-
Hoyt, J.C.; Robertson, E.F.; Berlyn, K.A.; Reeves, H.C.
Escherichia coli isocitrate lyase: properties and comparisons
Biochim. Biophys. Acta
966
30-35
1988
Escherichia coli
Mackintosh, C.; Nimmo, H.G.
Purification and regulatory properties of isocitrate lyase from Escherichia coli ML308
Biochem. J.
250
25-31
1988
Escherichia coli
Uchida, M.; Ueda, M.; Matsuki, T.; Okada, H.; Tanaka, A.; Fukui, S.
Properties of isocitrate lyase from an alkane-utilizable yeast Candida tropicalis
Agric. Biol. Chem.
50
127-134
1986
Candida tropicalis
-
Tanaka, A.; Nabeshima, S.; Tokuda, M.; Fukui, S.
Partial purification of isocitrate lyase from Candida tropicalis and some kinetic properties of the enzyme
Agric. Biol. Chem.
41
795-801
1977
Candida tropicalis
-
Tsukamoto, C.; Ejiri, S.I.; Katsumata, T.
Purification and some properties of isocitrate lyase from the pollen of Pinus densiflora Sieb. et Zucc.
Agric. Biol. Chem.
50
409-416
1986
Pinus densiflora
-
Giachetti, E.; Pinzauti, G.; Bonaccorsi, R.; Vanni, P.
Isocitrate lyase from Pinus pinea. Characterization of its true substrate and the action of magnesium ions
Eur. J. Biochem.
172
85-91
1988
Pinus pinea
Pinzauti, G.; Giachetti, E.; Camici, G.; Manao, G.; Cappugi, G.; Vanni, P.
An isocitrate lyase of higher plants: analysis and comparison of some molecular properties
Arch. Biochem. Biophys.
244
85-93
1986
Pinus pinea
Takao, S.; Takahashi, T.; Tanida, M.; Takahashi, M.
Purification and some properties of isocitrate lyase from Paecilomyces varioti with high malic acid production
J. Ferment. Technol.
62
577-582
1984
Paecilomyces variotii
-
Jameel, S.; El-Gul, T.; McFadden, B.A.
Isolation and properties of watermelon isocitrate lyase
Phytochemistry
23
2753-2759
1984
Citrullus lanatus subsp. vulgaris
-
Schloss, J.V.; Cleland, W.W.
Inhibition of isocitrate lyase by 3-nitropropionate, a reaction-intermediate analogue
Biochemistry
21
4420-4427
1982
Vogesella indigofera
McFadden, B.A.; Howes, W.V.
Crystallization and some properties of isocitrate lyase from Pseudomonas indigofera
J. Biol. Chem.
238
1737-1742
1963
Vogesella indigofera
-
Shiio, I.; Shiio, T.; McFadden, B.A.
Isocitrate lyase from Pseudomonas indigofera. I. Preparation, amino acid composition and molecular weight
Biochim. Biophys. Acta
96
114-122
1965
Vogesella indigofera
Malhotra, O.P.; Srivastava, P.K.
Isolation and characterization of isocitrate lyase of castor endosperm
Arch. Biochem. Biophys.
214
164-171
1982
Ricinus communis
Vicenzini, M.T.; Nerozzi, F.; Vincieri, F.F.; Vanni, P.
Isolation and properties of isocitrate lyase from Lupinus seed
Phytochemistry
19
769-774
1980
Lupinus sp.
-
Vanni, P.; Vicenzini, M.T.; Nerozzi, F.M.; Sinha, S.P.
Studies on isocitrate lyase isolated from Lupinus cotyledons
Can. J. Biochem.
57
1131-1137
1979
Lupinus sp.
Frevert, J.; Kindl, H.
Plant microbody proteins. Purification and glycoprotein nature of glyoxysomal isocitrate lyase from cucumber cotyledons
Eur. J. Biochem.
92
35-43
1978
Cucumis sativus
Chell, R.M.; Sundaram, T.K.
Isolation and characterization of isocitrate lyase and malate synthase from Bacillus stearothermophilus
Biochem. Soc. Trans.
3
303-306
1975
Geobacillus stearothermophilus
Griffiths, M.W.; Sundaram, T.K.
Isocitrate lyase from a thermophilic Bacillus: effect of salts on enzyme activity
J. Bacteriol.
116
1160-1169
1973
Bacillus sp. (in: Bacteria)
Chell, R.M.; Sundaram, T.K.; Wilkinson, A.E.
Isolation and characterization of isocitrate lyase from a thermophilic Bacillus sp.
Biochem. J.
173
165-177
1978
Bacillus sp. (in: Bacteria)
Reiss, U.; Rothstein, M.
Isocitrate lyase from the free-living nematode, Tubatrix aceti: purification and properties
Biochemistry
13
1796-1800
1974
Turbatrix aceti
Johanson, R.A.; Hill, J.M.; McFadden, B.A.
Isocitrate lyase from Neurospora crassa. I. Purification, kinetic mechanism, and interaction with inhibitors
Biochim. Biophys. Acta
364
327-340
1974
Neurospora crassa, Vogesella indigofera
Giachetti, E.G.; Pinzauti, G.; Bonaccorsi, R.; Vincenzini, M.T.; Vanni, P.
Isocitrate lyase from higher plants
Phytochemistry
26
2439-2446
1987
Ricinus communis, Citrullus lanatus subsp. vulgaris, Cucumis sativus, Helianthus annuus, Linum usitatissimum, Lupinus sp., Pinus densiflora, Pinus pinea
-
Khan, F.R.; Sallemuddin, M.; Siddiqi, M; McFadden, B.A.
Purification and properties of isocitrate lyase from flax seedlings
Arch. Biochem. Biophys.
183
13-23
1977
Linum usitatissimum
Hoyt, J.C.; Johnson, K.E.; Reeves, H.C.
Purification and characterization of Acinetobacter calcoaceticus isocitrate lyase
J. Bacteriol.
173
6844-6848
1991
Acinetobacter calcoaceticus
DeLucas, J.R.Amor.C.; Diaz, M.; Turner, G.; Laborda, F.
Purification and properties of isocitrate lyase from Aspergillus nidulans, a model enzyme to study catabolite inactivation in filamentous fungi
Mycol. Res.
101
410-414
1997
Aspergillus nidulans
Langridge, S.J.; Baker, P.J.; DeLucas, J.R.; Sedelnikova, S.E.; Turner, G.; Rice, D.W.
Isocitrate lyase from Aspergillus nidulans: Crystallization and X-ray analysis of a glyoxylate cycle enzyme
Acta Crystallogr. Sect. D
53
488-490
1997
Aspergillus nidulans
Gainey, L.D.S.; Connerton, I.F.; Lewis, E.H.; Turner, G.; Balance, D.J.
Characterization of the glyoxysomal isocitrate lyase genes of Aspergillus nidulans (acuD) and Neurospora crassa (acu-3)
Curr. Genet.
21
43-47
1992
Aspergillus nidulans, Neurospora crassa
Atomi, H.; Ueda, M.; Hikida, M.; Hishida, T.; Teranbishi, Y.; Tanaka, A.
Peroxisomal isocitrate lyase of the n-alkane-assimilating yeast Candida tropicalis: gene analysis and characterization
J. Biochem.
107
262-266
1990
Candida tropicalis
Turley, R.B.; Choe, S.M.; Trelease, R.N.
Characterization of a cDNA clone encoding the complete amino acid sequence of cotton isocitrate lyase
Biochim. Biophys. Acta
1049
223-226
1990
Gossypium hirsutum (P17069), Gossypium hirsutum
Zarembinski, C.M.; Hoyt, J.C.; Reeves, H.C.
Properties of isocitrate lyase from Escherichia coli K12 grown on acetate or glycolate
Curr. Microbiol.
22
65-68
1991
Escherichia coli
-
Khan, A.S.; VanDriessche, E.; Kanarek, L.; Beeckmans, S.
The purification and physicochemical characterization of maize (Zea mays L.) isocitrate lyase
Arch. Biochem. Biophys.
297
9-18
1992
Zea mays
Tanaka, Y.; Yoshida, T.; Watanabe, K.; Izumi, Y.; Mitsunaga, T.
Characterization, gene cloning and expression of isocitrate lyase involved in the assimilation of one-carbon compounds in Hyphomicrobium methylovorum GM2
Eur. J. Biochem.
249
820-825
1997
Hyphomicrobium methylovorum
Hnes, I.; Simon, M.; Weber, H.
Characterization of isocitrate lyase from the yeast Yarrowia lipolytica
J. Basic Microbiol.
31
251-258
1991
Yarrowia lipolytica
-
Reynolds, S.J.; Smith, S.M.
The isocitrate lyase gene of cucumber: isolation, characterisation and expression in cotyledons following seed germination
Plant Mol. Biol.
27
487-497
1995
Cucumis sativus
Popov, V.N.; Igamberdiev, A.U.; Volvenkin, S.V.
Purification and characterization of isocitrate lyase and malate synthase from fasting rat liver
Biokhimiya
61
1898-1903
1996
Rattus norvegicus
Polanowski, A.J.; Obendorf, R.L.
Soybean isocitrate lyase: Purification, immunoassay and N-terminal sequence
Plant Physiol. Biochem.
29
119-129
1991
Glycine max
-
Nakamura, K.; Amano, Y.; Nakadate, M.; Kagami, M.
Purification and properties of isocitrate lyase from Candida brassicae E-17
J. Ferment. Bioeng.
67
153-157
1989
Candida brassicae
-
Mullen, R.T.; Gifford, D.J.
Isocitrate lyase from germinated loblolly pine megagametophytes: Enzyme purification and immunocharacterization
Plant Physiol. Biochem.
33
87-95
1995
Pinus taeda
-
Tahama, H.; Shinoyama, H.; Ando, A.; Fujh, T.
Purification and characterization of isocitrate lyase from Rhodopseudomonas sp. No. 7
Agric. Biol. Chem.
54
3177-3183
1990
Rhodopseudomonas sp.
-
Ko, Y.H.; McFadden, B.A.
The inhibition of isocitrate lyase from Escherichia coli by glyoxylate
Curr. Microbiol.
21
313-315
1990
Escherichia coli
-
Watanabe, S.; Takada, Y.; Fukunaga, N.
Purification and characterization of a cold-adapted isocitrate lyase and a malate synthase from Colwellia maris, a psychrophilic bacterium
Biosci. Biotechnol. Biochem.
65
1095-1103
2001
Colwellia maris
Britton, K.L.; Abeysinghe, I.S.B.; Baker, P.J.; Barynin, V.; Diehl, P.; Langridge, S.J.; McFadden, B.A.; Sedelnikova, S.E.; Stillman, T.J.; Weeradechapon, K.; Rice, D.W.
The structure and domain organization of Escherichia coli isocitrate lyase
Acta Crystallogr. Sect. D
D57
1209-1218
2001
Escherichia coli
Klinke, S.; Dauner, M.; Scott, G.; Kessler, B.; Witholt, B.
Inactivation of isocitrate lyase leads to increased production of medium-chain-length poly(3-hydroxyalkanoates) in Pseudomonas putida
Appl. Environ. Microbiol.
66
909-913
2000
Pseudomonas putida
Munir, E.; Hattori, T.; Shimada, M.
Purification and characterization of isocitrate lyase from the wood-destroying basidiomycete Fomitopsis palustris grown on glucose
Arch. Biochem. Biophys.
399
225-231
2002
Fomitopsis palustris
Soh, B.S.; Loke, P.; Sim, T.S.
Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585
Biochim. Biophys. Acta
1522
112-117
2001
Streptomyces clavuligerus (Q8RPZ0), Streptomyces clavuligerus, Streptomyces clavuligerus NRRL 3585 (Q8RPZ0)
Ranaldi, F.; Vanni, P.; Giachetti, E.
Enzyme catalysis in microgravity: steady-state kinetic analysis of the isocitrate lyase reaction
Biophys. Chem.
103
169-177
2003
Pinus pinea
Lopez, M.L.; Redruello, B.; Valdes, E.; Moreno, F.; Heinisch, J.J.; Rodicio, R.
Isocitrate lyase of the yeast Kluyveromyces lactis is subject to glucose repression but not to catabolite inactivation
Curr. Genet.
44
305-316
2004
Kluyveromyces lactis
Watanabe, S.; Yamaoka, N.; Fukunaga, N.; Takada, Y.
Purification and characterization of a cold-adapted isocitrate lyase and expression analysis of the cold-inducible isocitrate lyase gene from the psychrophilic bacterium Colwellia psychrerythraea
Extremophiles
6
397-405
2002
Colwellia maris
Rua, J.; Soler, J.; Busto, F.; de Arriaga, D.
Specific and reversible inactivation of Phycomyces blakesleeanus isocitrate lyase by ascorbate-iron: role of two redox-active cysteines
Fungal Genet. Biol.
35
223-234
2002
Phycomyces blakesleeanus
Honer Zu Bentrup, K.; Miczak, A.; Swenson, D.L.; Russell, D.G.
Characterization of activity and expression of isocitrate lyase in Mycobacterium avium and Mycobacterium tuberculosis
J. Bacteriol.
181
7161-7167
1999
Mycobacterium tuberculosis
Kelly, B.G.; Wall, D.M.; Boland, C.A.; Meijer, W.G.
Isocitrate lyase of the facultative intracellular pathogen Rhodococcus equi
Microbiology
148
793-798
2002
Rhodococcus equi
Runquist, M.; Kruger, N.J.
Control of gluconeogenesis by isocitrate lyase in endosperm of germinating castor bean seedlings
Plant J.
19
423-431
1999
Ricinus communis
Ranaldi, F.; Vanni, P.; Giachetti, E.
Multisite inhibition of Pinus pinea isocitrate lyase by phosphate
Plant Physiol.
124
1131-1138
2000
Pinus pinea
Britton, K.; Langridge, S.; Baker, P.J.; Weeradechapon, K.; Sedelnikova, S.E.; De Lucas, J.R.; Rice, D.W.; Turner, G.
The crystal structure and active site location of isocitrate lyase from the fungus Aspergillus nidulans
Structure
8
349-362
2000
Aspergillus nidulans
Nakazawa, M.; Minami, T.; Teramura, K.; Kumamoto, S.; Hanato, S.; Takenaka, S.; Ueda, M.; Inui, H.; Nakano, Y.; Miyatake, K.
Molecular characterization of a bifunctional glyoxylate cycle enzyme, malate synthase/isocitrate lyase, in Euglena gracilis
Comp. Biochem. Physiol. B
141
445-452
2005
Euglena gracilis (Q8LPA6), Euglena gracilis, Euglena gracilis SM-ZK (Q8LPA6)
Lu, Y.; Wu, Y.R.; Han, B.
Anaerobic induction of isocitrate lyase and malate synthase in submerged rice seedlings indicates the important metabolic role of the glyoxylate cycle
Acta Biochim. Biophys. Sin.
37
406-414
2005
Oryza sativa
Yanik, T.; Donaldson, R.P.
A protective association between catalase and isocitrate lyase in peroxisomes
Arch. Biochem. Biophys.
435
243-252
2005
Ricinus communis
Hamel, R.; Appanna, V.D.; Viswanatha, T.; Puiseux-Dao, S.
Overexpression of isocitrate lyase is an important strategy in the survival of Pseudomonas fluorescens exposed to aluminum
Biochem. Biophys. Res. Commun.
317
1189-1194
2004
Pseudomonas fluorescens, Pseudomonas fluorescens 13525
Lu, Z.; Feng, X.; Song, L.; Han, Y.; Kim, A.; Herzberg, O.; Woodson, W.R.; Martin, B.M.; Mariano, P.S.; Dunaway-Mariano, D.
Diversity of function in the isocitrate lyase enzyme superfamily: the Dianthus caryophyllus petal death protein cleaves alpha-keto and alpha-hydroxycarboxylic acids
Biochemistry
44
16365-16376
2005
Dianthus caryophyllus (Q05957), Dianthus caryophyllus
Eprintsev, A.T.; Shevchenko, M.Y.; Popov, V.N.
Purification and properties of isocitrate lyase from pupas of the butterfly Papilio machaon L
Biochemistry (Moscow)
69
376-380
2004
Papilio machaon
Wall, D.M.; Duffy, P.S.; Dupont, C.; Prescott, J.F.; Meijer, W.G.
Isocitrate lyase activity is required for virulence of the intracellular pathogen Rhodococcus equi
Infect. Immun.
73
6736-6741
2005
Rhodococcus equi (A0A3S5YB92)
Watanabe, S.; Takada, Y.
Amino acid residues involved in cold adaptation of isocitrate lyase from a psychrophilic bacterium, Colwellia maris
Microbiology
150
3393-3403
2004
Colwellia maris, Escherichia coli (P0A9G6), Escherichia coli
Munoz-Elias, E.J.; McKinney, J.D.
Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
Nat. Med.
11
638-644
2005
Mycobacterium tuberculosis
Prasad Maharjan, R.; Yu, P.L.; Seeto, S.; Ferenci, T.
The role of isocitrate lyase and the glyoxylate cycle in Escherichia coli growing under glucose limitation
Res. Microbiol.
156
178-183
2005
Escherichia coli
Sakai, S.; Nishide, T.; Munir, E.; Baba, K.; Inui, H.; Nakano, Y.; Hattori, T.; Shimada, M.
Subcellular localization of glyoxylate cycle key enzymes involved in oxalate biosynthesis of wood-destroying basidiomycete Fomitopsis palustris grown on glucose
Microbiology
152
1857-1866
2006
Fomitopsis palustris (Q58A52), Fomitopsis palustris, Fomitopsis palustris TYP-6137 (Q58A52)
Kim, Y.R.; Brinsmade, S.R.; Yang, Z.; Escalante-Semerena, J.; Fierer, J.
Mutation of phosphotransacetylase but not isocitrate lyase reduces the virulence of Salmonella enterica serovar Typhimurium in mice
Infect. Immun.
74
2498-2502
2006
Salmonella enterica
Yang, H.C.; Yu, J.; Oh, K.B.; Shin, D.S.; Cho, W.J.; Shin, J.; Kim, S.
Synthesis and evaluation of hydroquinone derivatives as inhibitors of isocitrate lyase
Arch. Pharm. Res.
30
955-961
2007
Candida albicans
Lee, H.S.; Lee, T.H.; Yang, S.H.; Shin, H.J.; Shin, J.; Oh, K.B.
Sesterterpene sulfates as isocitrate lyase inhibitors from tropical sponge Hippospongia sp.
Bioorg. Med. Chem. Lett.
17
2483-2486
2007
Pyricularia grisea
Abba, S.; Balestrini, R.; Benedetto, A.; Rottensteiner, H.; De Lucas, J.R.; Bonfante, P.
The role of the glyoxylate cycle in the symbiotic fungus Tuber borchii: expression analysis and subcellular localization
Curr. Genet.
52
159-170
2007
Tuber borchii
Bai, B.; Xie, J.; Yan, J.; Wang, H.; Hu, C.
A high throughput screening approach to identify isocitrate lyase inhibitors from traditional Chinese medicine sources
Drug Dev. Res.
67
818-823
2006
Mycobacterium tuberculosis
-
Sato, Y.; Watanabe, S.; Yamaoka, N.; Takada, Y.
Gene cloning of cold-adapted isocitrate lyase from a psychrophilic bacterium, Colwellia psychrerythraea, and analysis of amino acid residues involved in cold adaptation of this enzyme
Extremophiles
12
107-117
2008
Colwellia psychrerythraea (A8C5K8), Colwellia psychrerythraea, Colwellia psychrerythraea NRC 1004 (A8C5K8)
Uhrigshardt, H.; Walden, M.; John, H.; Petersen, A.; Anemller, S.
Evidence for an operative glyoxylate cycle in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius
FEBS Lett.
513
223-229
2002
Sulfolobus acidocaldarius
Diaz-Perez, A.L.; Roman-Doval, C.; Diaz-Perez, C.; Cervantes, C.; Sosa-Aguirre, C.R.; Lopez-Meza, J.E.; Campos-Garcia, J.
Identification of the aceA gene encoding isocitrate lyase required for the growth of Pseudomonas aeruginosa on acetate, acyclic terpenes and leucine
FEMS Microbiol. Lett.
269
309-316
2007
Pseudomonas aeruginosa (Q9I0K4), Pseudomonas aeruginosa
Ebel, F.; Schwienbacher, M.; Beyer, J.; Heesemann, J.; Brakhage, A.A.; Brock, M.
Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development
Fungal Genet. Biol.
43
476-489
2006
Aspergillus fumigatus, Aspergillus fumigatus ATCC 46645
Schoebel, F.; Ibrahim-Granet, O.; Ave, P.; Latge, J.P.; Brakhage, A.A.; Brock, M.
Aspergillus fumigatus does not require fatty acid metabolism via isocitrate lyase for development of invasive aspergillosis
Infect. Immun.
75
1237-1244
2007
Aspergillus fumigatus
Lee, H.S.; Lee, T.H.; Lee, J.H.; Chae, C.S.; Chung, S.C.; Shin, D.S.; Shin, J.; Oh, K.B.
Inhibition of the pathogenicity of Magnaporthe grisea by bromophenols, isocitrate lyase inhibitors, from the red alga Odonthalia corymbifera
J. Agric. Food Chem.
55
6923-6928
2007
Pyricularia grisea, Pyricularia grisea Guy 11
Ogawa, T.; Murakami, K.; Mori, H.; Ishii, N.; Tomita, M.; Yoshin, M.
Role of phosphoenolpyruvate in the NADP-isocitrate dehydrogenase and isocitrate lyase reaction in Escherichia coli
J. Bacteriol.
189
1176-1178
2007
Escherichia coli, Escherichia coli K-12 W3110
Ramirez-Trujillo, J.A.; Encarnacion, S.; Salazar, E.; de los Santos, A.G.; Dunn, M.F.; Emerich, D.W.; Calva, E.; Hernandez-Lucas, I.
Functional characterization of the Sinorhizobium meliloti acetate metabolism genes aceA, SMc00767, and glcB
J. Bacteriol.
189
5875-5884
2007
Sinorhizobium meliloti, Sinorhizobium meliloti Rm5000
Gould, T.A.; van de Langemheen, H.; Munoz-Elias, E.J.; McKinney, J.D.; Sacchettini, J.C.
Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis
Mol. Microbiol.
61
940-947
2006
Mycobacterium tuberculosis (P9WKK7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKK7)
Selmar, D.; Bytof, G.; Knopp, S.; Breitenstein, B.
Germination of coffee seeds and its significance for coffee quality
Plant Biol.
8
260-264
2006
Coffea arabica
Savvi, S.; Warner, D.F.; Kana, B.D.; McKinney, J.D.; Mizrahi, V.; Dawes, S.S.
Functional characterization of a vitamin B12-dependent methylmalonyl pathway in Mycobacterium tuberculosis: implications for propionate metabolism during growth on fatty acids
J. Bacteriol.
190
3886-3895
2008
Mycobacterium tuberculosis
Lee, H.S.; Yoon, K.M.; Han, Y.R.; Lee, K.J.; Chung, S.C.; Kim, T.I.; Lee, S.H.; Shin, J.; Oh, K.B.
5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp
Bioorg. Med. Chem. Lett.
19
1051-1053
2009
Candida albicans
Li, J.; Li, N.; Zhu, D.; Wan, L.; He, Y.; Yang, C.
Isocitrate lyase from Mycobacterium tuberculosis promotes survival of Mycobacterium smegmatis within macrophage by suppressing cell apoptosis
Chin. Med. J.
121
1114-1119
2008
Mycobacterium tuberculosis, Mycolicibacterium smegmatis, Mycolicibacterium smegmatis 1-2c, Mycobacterium tuberculosis H37Rv
Sanchez, N.S.; Arreguin, R.; Calahorra, M.; Pena, A.
Effects of salts on aerobic metabolism of Debaryomyces hansenii
FEMS Yeast Res.
8
1303-1312
2008
Debaryomyces hansenii, Debaryomyces hansenii Y7426
Thirach, S.; Cooper, C.R.; Vanittanakom, N.
Molecular analysis of the Penicillium marneffei glyceraldehyde-3-phosphate dehydrogenase-encoding gene (gpdA) and differential expression of gpdA and the isocitrate lyase-encoding gene (acuD) upon internalization by murine macrophages
J. Med. Microbiol.
57
1322-1328
2008
Talaromyces marneffei, Talaromyces marneffei CBS 119456
Song, J.; Jeong, W.; Wang, N.; Lee, H.; Sim, C.J.; Oh, K.; Shin, J.
Scalarane Sesterterpenes from the Sponge Smenospongia sp
J. Nat. Prod.
71
1866-1871
2008
Candida albicans
Singh, R.; Lemire, J.; Mailloux, R.J.; Appanna, V.D.
A novel strategy involved anti-oxidative defense: the conversion of NADH into NADPH by a metabolic network
PLoS ONE
3
e2682
2008
Pseudomonas fluorescens
Kumar, R.; Bhakuni, V.
Mycobacterium tuberculosis isocitrate lyase (MtbIcl): role of divalent cations in modulation of functional and structural properties
Proteins
72
892-900
2008
Mycobacterium tuberculosis
Eprintsev, A.T.; Maslova, E.V.; Fedorin, D.N.; Popov, V.N.
Physicochemical and kinetic characteristics of isoforms of isocitrate lyase from corn
Biochemistry (Moscow)
74
528-532
2009
Zea mays
van Schaik, E.J.; Tom, M.; Woods, D.E.
Burkholderia pseudomallei isocitrate lyase is a persistence factor in pulmonary melioidosis: implications for the development of isocitrate lyase inhibitors as novel antimicrobials
Infect. Immun.
77
4275-4283
2009
Burkholderia pseudomallei
Bedhomme, M.; Zaffagnini, M.; Marchand, C.H.; Gao, X.H.; Moslonka-Lefebvre, M.; Michelet, L.; Decottignies, P.; Lemaire, S.D.
Regulation by glutathionylation of isocitrate lyase from Chlamydomonas reinhardtii
J. Biol. Chem.
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Chlamydomonas reinhardtii
Sriram, D.; Yogeeswari, P.; Senthilkumar, P.; Dewakar, S.; Rohit, N.; Debjani, B.; Bhat, P.; Veugopal, B.; Pavan, V.V.; Thimmappa, H.M.
Novel phthalazinyl derivatives: synthesis, antimycobacterial activities, and inhibition of Mycobacterium tuberculosis isocitrate lyase enzyme
Med. Chem.
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Mycobacterium tuberculosis
Meijer, S.; Otero, J.; Olivares, R.; Andersen, M.R.; Olsson, L.; Nielsen, J.
Overexpression of isocitrate lyase-glyoxylate bypass influence on metabolism in Aspergillus niger
Metab. Eng.
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Aspergillus niger, Aspergillus niger N402
Dunn, M.F.; Ramirez-Trujillo, J.A.; Hernandez-Lucas, I.
Major roles of isocitrate lyase and malate synthase in bacterial and fungal pathogenesis
Microbiology
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2009
Aspergillus fumigatus, Aspergillus nidulans, Candida albicans, Colletotrichum lagenaria, Rhodococcus equi, Cryptococcus neoformans, Escherichia coli, Leptosphaeria maculans, Pyricularia grisea, Mycobacterium tuberculosis, Mycobacterium avium, Yersinia pestis, Yersinia pseudotuberculosis, Pseudomonas aeruginosa, Sinorhizobium meliloti, Rhizobium tropici, Salmonella enterica subsp. enterica serovar Typhimurium, Yersinia enterocolitica, Paracoccidioides brasiliensis, Brucella suis, Talaromyces marneffei
Gengenbacher, M.; Rao, S.P.; Pethe, K.; Dick, T.
Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability
Microbiology
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2010
Mycobacterium tuberculosis (P9WKK7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKK7)
Eprintsev, A.; Dyachenko, E.; Lykova, T.; Kuen, C.; Popov, V.
Preparation and properties of isocitrate lyase isoforms from the cotyledons of Glycine max L
Appl. Biochem. Microbiol.
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Glycine max
Oh, K.B.; Jeon, H.B.; Han, Y.R.; Lee, Y.J.; Park, J.; Lee, S.H.; Yang, D.; Kwon, M.; Shin, J.; Lee, H.S.
Bromophenols as Candida albicans isocitrate lyase inhibitors
Bioorg. Med. Chem. Lett.
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2010
Candida albicans, Candida albicans ATCC 10231
Lee, Y.J.; Han, Y.R.; Park, W.; Nam, S.H.; Oh, K.B.; Lee, H.S.
Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase
Bioorg. Med. Chem. Lett.
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2010
Candida albicans
Chung, S.C.; Jang, K.H.; Park, J.; Ahn, C.H.; Shin, J.; Oh, K.B.
Sargachromanols as inhibitors of Na+/K+ ATPase and isocitrate lyase
Bioorg. Med. Chem. Lett.
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Candida albicans, Candida albicans ATCC 10231
Sriram, D.; Yogeeswari, P.; Methuku, S.; Vyas, D.R.; Senthilkumar, P.; Alvala, M.; Jeankumar, V.U.
Synthesis of various 3-nitropropionamides as Mycobacterium tuberculosis isocitrate lyase inhibitor
Bioorg. Med. Chem. Lett.
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Mycobacterium tuberculosis
Cruz, A.H.; Brock, M.; Zambuzzi-Carvalho, P.F.; Santos-Silva, L.K.; Troian, R.F.; Goes, A.M.; Soares, C.M.; Pereira, M.
Phosphorylation is the major mechanism regulating isocitrate lyase activity in Paracoccidioides brasiliensis yeast cells
FEBS J.
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Paracoccidioides brasiliensis (Q5YLB6), Paracoccidioides brasiliensis
Nunn, C.E.; Johnsen, U.; Schoenheit, P.; Fuhrer, T.; Sauer, U.; Hough, D.W.; Danson, M.J.
Metabolism of pentose sugars in the hyperthermophilic archaea Sulfolobus solfataricus and Sulfolobus acidocaldarius
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Saccharolobus solfataricus (Q97YI8), Saccharolobus solfataricus P2 (Q97YI8)
Nakazawa, M.; Nishimura, M.; Inoue, K.; Ueda, M.; Inui, H.; Nakano, Y.; Miyatake, K.
Characterization of a bifunctional glyoxylate cycle enzyme, malate synthase/isocitrate lyase, of Euglena gracilis
J. Eukaryot. Microbiol.
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Euglena gracilis (Q8LPA6), Euglena gracilis
Hagins, J.M.; Scoffield, J.A.; Suh, S.J.; Silo-Suh, L.
Influence of RpoN on isocitrate lyase activity in Pseudomonas aeruginosa
Microbiology
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Pseudomonas aeruginosa
Beste, D.; Bonde, B.; Hawkins, N.; Ward, J.; Beale, M.; Noack, S.; Nh, K.; Kruger, N.; Ratcliffe, R.; McFadden, J.
13C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation
PLoS Pathog.
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Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis, Mycobacterium tuberculosis H37Rv
Maeda, T.; Wachi, M.
3' Untranslated region-dependent degradation of the aceA mRNA, encoding the glyoxylate cycle enzyme isocitrate lyase, by RNase E/G in Corynebacterium glutamicum
Appl. Environ. Microbiol.
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Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 31831
Quartararo, C.E.; Hadi, T.; Cahill, S.M.; Blanchard, J.S.
Solvent isotope-induced equilibrium perturbation for isocitrate lyase
Biochemistry
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2013
Mycobacterium tuberculosis
Moynihan, M.M.; Murkin, A.S.
Cysteine is the general base that serves in catalysis by isocitrate lyase and in mechanism-based inhibition by 3-nitropropionate
Biochemistry
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2014
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37R
Ahn, C.H.; Won, T.H.; Kim, H.; Shin, J.; Oh, K.B.
Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp.
Bioorg. Med. Chem. Lett.
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Candida albicans (Q9P8Q7), Candida albicans
Tanaka, Y.; Hayashi, T.; Yamaoka, N.; Takada, Y.
Cloning and expression of the isocitrate lyase gene from a nitrogen-fixing bacterium, Azotobacter vinelandii, and functional analysis of the enzyme by site-directed mutagenesis
Biosci. Biotechnol. Biochem.
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Azotobacter vinelandii (A8C781), Azotobacter vinelandii, Azotobacter vinelandii IAM1078 (A8C781)
Kratky, M.; Vinsova, J.
Advances in mycobacterial isocitrate lyase targeting and inhibitors
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Mycobacterium tuberculosis
Kozic, J.; Novotna, E.; Volkova, M.; Stolarikova, J.; Trejtnar, F.; Wsol, V.; Vinsova, J.
Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2-hydroxybenzanilides, their thioxo analogues and benzoxazoles
Eur. J. Med. Chem.
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Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium kansasii, Mycobacterium kansasii My 235/80, Mycobacterium avium My 330/88, Mycobacterium kansasii 6509/96, Mycobacterium tuberculosis My 331/88
Serrano, J.A.; Camacho, M.; Bonete, M.J.
Operation of glyoxylate cycle in halophilic archaea: presence of malate synthase and isocitrate lyase in Haloferax volcanii
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Haloferax volcanii, Haloferax volcanii DSM 3757
Chung, J.C.; Rzhepishevska, O.; Ramstedt, M.; Welch, M.
Type III secretion system expression in oxygen-limited Pseudomonas aeruginosa cultures is stimulated by isocitrate lyase activity
Open biology
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Pseudomonas aeruginosa
Eoh, H.; Rhee, K.Y.
Methylcitrate cycle defines the bactericidal essentiality of isocitrate lyase for survival of Mycobacterium tuberculosis on fatty acids
Proc. Natl. Acad. Sci. USA
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Mycobacterium tuberculosis
Campos-Garcia, J.; Diaz-Perez, C.; Diaz-Perez, A.L.
Residues Asn214, Gln211, Glu219 and Gln221 contained in the subfamily 3 catalytic signature of the isocitrate lyase from Pseudomonas aeruginosa are involved in its catalytic and thermal properties
World J. Microbiol. Biotechnol.
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Pseudomonas aeruginosa (Q9I0K4), Pseudomonas aeruginosa
Ramirez-Trujillo, J.; Dunn, M.; Suarez-Rodriguez, R.; Hernandez-Lucas, I.
The Sinorhizobium meliloti glyoxylate cycle enzyme isocitrate lyase (AceA) is required for the utilization of poly-beta-hydroxybutyrate during carbon starvation
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Sinorhizobium meliloti
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Shukla, H.; Kumar, V.; Singh, A.K.; Singh, N.; Kashif, M.; Siddiqi, M.I.; Yasoda Krishnan, M.; Sohail Akhtar, M.
Insight into the structural flexibility and function of Mycobacterium tuberculosis isocitrate lyase
Biochimie
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2015
Mycobacterium tuberculosis (P9WKK7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKK7)
Lee, Y.V.; Wahab, H.A.; Choong, Y.S.
Potential inhibitors for isocitrate lyase of Mycobacterium tuberculosis and non-M. tuberculosis a summary
BioMed Res. Int.
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Acinetobacter calcoaceticus, Ricinus communis, Escherichia coli, Pyricularia grisea, Mycobacterium tuberculosis, Neurospora crassa, Vogesella indigofera, Candida albicans (Q9P8Q7)
Hayashi, T.; Matsuzaki, W.; Takada, Y.
Characterization of chimeric and mutated isocitrate lyases of a mesophilic nitrogen-fixing bacterium, Azotobacter vinelandii, and a psychrophilic bacterium, Colwellia maris
Biosci. Biotechnol. Biochem.
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Azotobacter vinelandii, Colwellia maris (Q93R40), Colwellia maris
Shukla, H.; Kumar, R.; Sonkar, A.; Mitra, K.; Akhtar, M.S.; Tripathi, T.
Salt-regulated reversible fibrillation of Mycobacterium tuberculosis isocitrate lyase Concurrent restoration of structure and activity
Int. J. Biol. Macromol.
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Mycobacterium tuberculosis
Jeon, J.M.; Lee, H.I.; Sadowsky, M.J.; Sugawara, M.; Chang, W.S.
Characterization of a functional role of the Bradyrhizobium japonicum isocitrate lyase in desiccation tolerance
Int. J. Mol. Sci.
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Bradyrhizobium japonicum, Bradyrhizobium japonicum USDA110
Lee, Y.V.; Choi, S.B.; Wahab, H.A.; Choong, Y.S.
Active site flexibility of Mycobacterium tuberculosis isocitrate lyase in dimer form
J. Chem. Inf. Model.
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Mycobacterium tuberculosis
Eprintsev, A.T.; Fedorin, D.N.; Salnikov, A.V.; Igamberdiev, A.U.
Expression and properties of the glyoxysomal and cytosolic forms of isocitrate lyase in Amaranthus caudatus L
J. Plant Physiol.
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Amaranthus caudatus
Famiani, F.; Paoletti, A.; Battistelli, A.; Moscatello, S.; Chen, Z.H.; Leegood, R.C.; Walker, R.P.
Phosphoenolpyruvate carboxykinase, pyruvate orthophosphate dikinase and isocitrate lyase in both tomato fruits and leaves, and in the flesh of peach and some other fruits
J. Plant Physiol.
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Capsicum annuum, Solanum lycopersicum
Park, Y.; Cho, Y.; Lee, Y.H.; Lee, Y.W.; Rhee, S.
Crystal structure and functional analysis of isocitrate lyases from Magnaporthe oryzae and Fusarium graminearum
J. Struct. Biol.
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Pyricularia oryzae (P0CT06), Pyricularia oryzae, Fusarium graminearum (Q4HYR2), Fusarium graminearum
Gruendel, M.; Knoop, H.; Steuer, R.
Activity and functional properties of the isocitrate lyase in the cyanobacterium Cyanothece sp. PCC 7424
Microbiology
163
731-744
2017
Gloeothece citriformis PCC 7424
Liu, J.; Wang, Q.L.; Chang, Q.; Han, L.N.; Pei, G.L.; Xue, Y.Q.; Jia, L.M.; Zhang, K.; Duan, Y.Y.; Kang, Z.S.
Isocitrate lyase is required for urediniospore germination of Puccinia striiformis f. sp. tritici
Mol. Biol. Rep.
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7797-7806
2014
Puccinia striiformis f. sp. tritici, Puccinia striiformis f. sp. tritici CYR32
Nandakumar, M.; Nathan, C.; Rhee, K.Y.
Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis
Nat. Commun.
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4306
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Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Park, S.; Lee, Y.; Won, H.; Oh, K.; Lee, H.
Indole alkaloids from tropical sponge Hyrtios sp. as isocitrate lyase inhibitors
Nat. Prod. Commun.
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683-685
2018
Candida albicans
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Shukla, H.; Shukla, R.; Sonkar, A.; Pandey, T.; Tripathi, T.
Distant Phe345 mutation compromises the stability and activity of Mycobacterium tuberculosis isocitrate lyase by modulating its structural flexibility
Sci. Rep.
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1058
2017
Mycobacterium tuberculosis (P9WKK7), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WKK7)
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