Reference on EC 3.1.3.4 - phosphatidate phosphatase and Organism(s) Homo sapiens and UniProt Accession Q92539
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Roberts, R.; Sciorra, V.A.; Morris, A.J.
Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform
J. Biol. Chem.
273
22059-22067
1998
Homo sapiens
Balboa, M.A.; Balsinde, J.; Dennis, E.A.
Involvement of phosphatidate phosphohydrolase in arachidonic acid mobilization in human amniotic WISH cells
J. Biol. Chem.
273
7684-7690
1998
Homo sapiens
Kai, M.; Wada, I.; Imai, S.; Sakane, F.; Kanoh, H.
Cloning and characterization of two human isozymes of Mg2+-independent phosphatidic acid phosphatase
J. Biol. Chem.
272
24572-24578
1997
Homo sapiens
Taylor, G.S.; Ladd, A.; James, J.; Greene, B.; English, D.
Characterization of phosphatidic acid phosphohydrolase in neutrophil subcellular fractions
Biochim. Biophys. Acta
1175
219-224
1993
Homo sapiens
Day, C.P.; Burt, A.D.; Brown, A.S.M.; Bennett, M.K.; Farrell, D.J.; James, O.F.W.; Yeaman, S.J.
Plasma membrane form of phosphatidate phosphohydrolase: a possible role in signal transduction during liver fibrogenesis
Clin. Sci.
85
281-287
1993
Homo sapiens
English, D.; Martin, M.; Harvea, K.A.; Akard, L.P.; Allen, R.; Widlanski, T.S.; Garcia, J.G.; Siddiqui, R.A.
Characterization and purification of neutrophil ecto-phosphatidic acid phosphohydrolase
Biochem. J.
324
941-950
1997
Homo sapiens
-
Ishikawa, T.; Kai, M.; Wada, I.; Kanoh, H.
Cell surface activities of the human type 2b phosphatidic acid phosphatase
J. Biochem.
127
645-651
2000
Homo sapiens
Fuentes, L.; Perez, R.; Nieto, M.L.; Balsinde, J.; Balboa, M.A.
Bromoenol lactone promotes cell death by a mechanism involving phosphatidate phosphohydrolase-1 rather than calcium-independent phospholipase A2
J. Biol. Chem.
278
44683-44690
2003
Homo sapiens
Long, J.; Darroch, P.; Wan, K.F.; Kong, K.C.; Ktistakis, N.; Pyne, N.J.; Pyne, S.
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools
Biochem. J.
391
25-32
2005
Homo sapiens
Pyne, S.; Long, J.S.; Ktistakis, N.T.; Pyne, N.J.
Lipid phosphate phosphatases and lipid phosphate signalling
Biochem. Soc. Trans.
33
1370-1374
2005
Canis lupus familiaris, Homo sapiens, Mus musculus, Rattus norvegicus
Han, G.S.; Wu, W.I.; Carman, G.M.
The Saccharomyces cerevisiae lipin homologue is a Mg2+-dependent phosphatidate phosphatase enzyme
J. Biol. Chem.
281
9210-9218
2006
Saccharomyces cerevisiae, Homo sapiens
Brindley, D.N.
Lipid phosphate phosphatases and related proteins: signaling functions in development, cell division, and cancer
J. Cell. Biochem.
92
900-912
2004
Drosophila melanogaster, Mus musculus, Rattus norvegicus, Homo sapiens (Q6T4P5), Homo sapiens (Q7Z2D5), Homo sapiens (Q8TBJ4), Homo sapiens (Q96GM1)
Sun, L.; Gu, S.; Sun, Y.; Zheng, D.; Wu, Q.; Li, X.; Dai, J.; Ji, C.; Xie, Y.; Mao, Y.
Cloning and characterization of a novel human phosphatidic acid phosphatase type 2, PAP2d, with two different transcripts PAP2d_v1 and PAP2d_v2
Mol. Cell. Biochem.
272
91-96
2005
Homo sapiens, Homo sapiens (Q32ZL2)
Pyne, S.; Kong, K.C.; Darroch, P.I.
Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases
Semin. Cell Dev. Biol.
15
491-501
2004
Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Burgdorf, C.; Prey, A.; Richardt, G.; Kurz, T.
A HPLC-fluorescence detection method for determination of phosphatidic acid phosphohydrolase activity: application in human myocardium
Anal. Biochem.
374
291-297
2008
Homo sapiens, Rattus norvegicus
Ishida, T.; Iwai, A.; Hijikata, M.; Shimotohno, K.
The expression of phosphatidic acid phosphatase 2a, which hydrolyzes lipids to generate diacylglycerol, is regulated by p73, a member of the p53 family
Biochem. Biophys. Res. Commun.
353
74-79
2007
Homo sapiens
Mechtcheriakova, D.; Wlachos, A.; Sobanov, J.; Bornancin, F.; Zlabinger, G.; Baumruker, T.; Billich, A.
FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3
FEBS Lett.
581
3063-3068
2007
Homo sapiens, Mus musculus
Takeuchi, M.; Harigai, M.; Momohara, S.; Ball, E.; Abe, J.; Furuichi, K.; Kamatani, N.
Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase
Gene
399
174-180
2007
Homo sapiens (Q5VZY2), Homo sapiens (Q8NEB5)
Kai, M.; Sakane, F.; Jia, Y.; Imai, S.; Yasuda, S.; Kanoh, H.
Lipid phosphate phosphatases 1 and 3 are localized in distinct lipid rafts
J. Biochem.
140
677-686
2006
Homo sapiens
Grkovich, A.; Johnson, C.A.; Buczynski, M.W.; Dennis, E.A.
Lipopolysaccharide-induced cyclooxygenase-2 expression in human U937 macrophages is phosphatidic acid phosphohydrolase-1-dependent
J. Biol. Chem.
281
32978-32987
2006
Homo sapiens
Morris, K.E.; Schang, L.M.; Brindley, D.N.
Lipid phosphate phosphatase-2 activity regulates S-phase entry of the cell cycle in Rat2 fibroblasts
J. Biol. Chem.
281
9297-9306
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Sigal, Y.J.; Quintero, O.A.; Cheney, R.E.; Morris, A.J.
Cdc42 and ARP2/3-independent regulation of filopodia by an integral membrane lipid-phosphatase-related protein
J. Cell Sci.
120
340-352
2007
Homo sapiens (Q8TBJ4)
Albert, D.; Pergola, C.; Koeberle, A.; Dodt, G.; Steinhilber, D.; Werz, O.
The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes
J. Leukoc. Biol.
83
1019-1027
2008
Homo sapiens
McDermott, M.I.; Sigal, Y.J.; Crump, J.S.; Morris, A.J.
Enzymatic analysis of lipid phosphate phosphatases
Methods
39
169-179
2006
Homo sapiens, Mus musculus, Rattus norvegicus
Long, J.S.; Pyne, N.J.; Pyne, S.
Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function
Biochem. J.
411
371-377
2008
Cavia porcellus, Cricetulus griseus, Homo sapiens, Mus musculus
Theofilopoulos, S.; Lykidis, A.; Leondaritis, G.; Mangoura, D.
Novel function of the human presqualene diphosphate phosphatase as a type II phosphatidate phosphatase in phosphatidylcholine and triacylglyceride biosynthesis pathways
Biochim. Biophys. Acta
1781
731-742
2008
Homo sapiens
Grimsey, N.; Han, G.S.; OHara, L.; Rochford, J.J.; Carman, G.M.; Siniossoglou, S.
Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2
J. Biol. Chem.
283
29166-29174
2008
Mus musculus, Homo sapiens (Q14693)
Carman, G.M.; Han, G.
Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis
J. Biol. Chem.
284
2593-2597
2009
Saccharomyces cerevisiae, Homo sapiens, Mus musculus
Reue, K.; Brindley, D.N.
Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism
J. Lipid Res.
49
2493-2503
2008
Saccharomyces cerevisiae, Homo sapiens, Mus musculus, Rattus norvegicus
Ong, K.L.; Leung, R.Y.; Wong, L.Y.; Cherny, S.S.; Sham, P.C.; Lam, T.H.; Lam, K.S.; Cheung, B.M.
Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men
Am. J. Hypertens.
21
539-545
2008
Homo sapiens
Higashida, K.; Higuchi, M.; Terada, S.
Potential role of lipin-1 in exercise-induced mitochondrial biogenesis
Biochem. Biophys. Res. Commun.
374
587-591
2008
Homo sapiens, Rattus norvegicus
Brindley, D.N.; Pilquil, C.; Sariahmetoglu, M.; Reue, K.
Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases
Biochim. Biophys. Acta
1791
956-961
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Pyne, S.; Lee, S.C.; Long, J.; Pyne, N.J.
Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease
Cell. Signal.
21
14-21
2009
Drosophila melanogaster, Homo sapiens, Mus musculus
Mlinar, B.; Pfeifer, M.; Vrtacnik-Bokal, E.; Jensterle, M.; Marc, J.
Decreased lipin 1 beta expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome
Eur. J. Endocrinol.
159
833-839
2008
Homo sapiens
Ishimoto, K.; Nakamura, H.; Tachibana, K.; Yamasaki, D.; Ota, A.; Hirano, K.; Tanaka, T.; Hamakubo, T.; Sakai, J.; Kodama, T.; Doi, T.
Sterol-mediated regulation of human lipin 1 gene expression in hepatoblastoma cells
J. Biol. Chem.
284
22195-22205
2009
Homo sapiens
Donkor, J.; Zhang, P.; Wong, S.; OLoughlin, L.; Dewald, J.; Kok, B.P.; Brindley, D.N.; Reue, K.
A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2
J. Biol. Chem.
284
29968-29978
2009
Homo sapiens, Mus musculus, Mus musculus C57/BL6J
Zhang, P.; OLoughlin, L.; Brindley, D.N.; Reue, K.
Regulation of lipin-1 gene expression by glucocorticoids during adipogenesis
J. Lipid Res.
49
1519-1528
2008
Homo sapiens, Mus musculus
Reue, K.; Dwyer, J.R.
Lipin proteins and metabolic homeostasis
J. Lipid Res.
50 Suppl
S109-S114
2009
Homo sapiens, Mus musculus, Rattus norvegicus
Brindley, D.N.; Pilquil, C.
Lipid phosphate phosphatases and signaling
J. Lipid Res.
50 Suppl
S225-S230
2009
Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus
Humtsoe, J.O.; Liu, M.; Malik, A.B.; Wary, K.K.
Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures
Mol. Cell. Biol.
30
1593-1606
2010
Homo sapiens, Mus musculus
Bou Khalil, M.; Blais, A.; Figeys, D.; Yao, Z.
Lipin - The bridge between hepatic glycerolipid biosynthesis and lipoprotein metabolism
Biochim. Biophys. Acta
1801
1249-1259
2010
Homo sapiens, Mus musculus, Rattus norvegicus
Wang, H.; Zhang, J.; Qiu, W.; Han, G.S.; Carman, G.M.; Adeli, K.
Lipin-1gamma isoform is a novel lipid droplet-associated protein highly expressed in the brain
FEBS Lett.
585
1979-1984
2011
Homo sapiens
Chatterjee, I.; Humtsoe, J.O.; Kohler, E.E.; Sorio, C.; Wary, K.K.
Lipid phosphate phosphatase-3 regulates tumor growth via beta-catenin and Cyclin-D1 signaling
Mol. Cancer
10
51
2011
Homo sapiens
Kok, B.P.; Skene-Arnold, T.D.; Ling, J.; Benesch, M.G.; Dewald, J.; Harris, T.E.; Holmes, C.F.; Brindley, D.N.
Conserved residues in the N terminus of lipin-1 are required for binding to protein phosphatase-1c, nuclear translocation, and phosphatidate phosphatase activity
J. Biol. Chem.
289
10876-10886
2014
Homo sapiens (Q14693)
Busnelli, M.; Manzini, S.; Parolini, C.; Escalante-Alcalde, D.; Chiesa, G.
Lipid phosphate phosphatase 3 in vascular pathophysiology
Atherosclerosis
271
156-165
2018
Homo sapiens (O14495), Mus musculus (Q99JY8)
Touat-Hamici, Z.; Weidmann, H.; Blum, Y.; Proust, C.; Durand, H.; Iannacci, F.; Codoni, V.; Gaignard, P.; Therond, P.; Civelek, M.; Karabina, S.A.; Lusis, A.J.; Cambien, F.; Ninio, E.
Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function
Cardiovasc. Res.
112
702-713
2016
Homo sapiens (O14495), Homo sapiens
Mingorance, L.; Castro, V.; Avila-Perez, G.; Calvo, G.; Rodriguez, M.J.; Carrascosa, J.L.; Perez-Del-Pulgar, S.; Forns, X.; Gastaminza, P.
Host phosphatidic acid phosphatase lipin1 is rate limiting for functional hepatitis C virus replicase complex formation
PLoS Pathog.
14
e1007284
2018
Homo sapiens
