Application | Comment | Organism |
---|---|---|
additional information | fibroblasts that overexpress LPP1 enter S-phase at approximately the same time as vector control cells | Mus musculus |
additional information | fibroblasts that overexpress LPP3 enter S-phase at approximately the same time as vector control cells | Rattus norvegicus |
additional information | increasing LPP2 activity causes premature entry into S-phase, premature cyclin A expression and decreased rates of proliferation at high passage and accumulation in G2/M. Cells transduced with LPP2 activate the G2/M checkpoint and show characteristics of senescence at high passage | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
functional overexpression of GFP-tagged LPPs in rat2 fibroblasts, the transformed cells show reduced proliferation, overview | Homo sapiens |
rat2 fibroblasts transduced and overexpressed with LPP1 and mLPP1-GFP | Mus musculus |
rat2 fibroblasts transduced and overexpressed with LPP2, LPP2-GFP and mutant LPP2(R214K)-GFP | Homo sapiens |
rat2 fibroblasts transduced and overexpressed with LPP3-GFP or myc-LPP3 | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knock-down of LPPs in rat2 fibroblasts, phenotype, overview | Homo sapiens |
R214K | site-directed mutagenesis | Homo sapiens |
R214K | knock-down of endogenous LPP2 in fibroblasts delays cyclin A accumulation and entry into S-phase of the cell cycle. Cells overexpressing LPP2(R214K)-GFP show no significant change in LPP activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
siRNA | rat2 fibroblasts treated with siRNA for LPP2 show a ca. 60% decrease in mRNA for the targeted LPP | Homo sapiens | |
siRNA | rat2 fibroblasts treated with siRNA for LPP1 show about a 60% decrease in mRNA for the targeted LPP | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | wild-type and mutant | Homo sapiens | 5783 | - |
endosome | early stage, wild-type and mutant | Homo sapiens | 5768 | - |
membrane | - |
Homo sapiens | 16020 | - |
additional information | LLP2 is not localized in Golgi apparatus, mitochondria, nucleus, or nuclear membrane | Homo sapiens | - |
- |
additional information | not localized to the Golgi apparatus, mitochondria, nucleus, or nuclear membrane | Homo sapiens | - |
- |
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | wild-type and mutant | Homo sapiens | 5886 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
immunoprecipitation, band only visible at mRNA overexpression levels of 100fold or more | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | increasing LPP2 activity causes premature cyclin A expression and decreased LPP2 expression delays cyclin A expression, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
lyso-phosphatidic acid + H2O | - |
Mus musculus | monoacylglycerol + phosphate | - |
? | |
lyso-phosphatidic acid + H2O | - |
Homo sapiens | monoacylglycerol + phosphate | - |
? | |
lyso-phosphatidic acid + H2O | - |
Rattus norvegicus | monoacylglycerol + phosphate | - |
? | |
additional information | increasing LPP2 activity causes premature cyclin A expression and decreased LPP2 expression delays cyclin A expression, overview | Homo sapiens | ? | - |
? | |
phosphatidic acid + H2O | - |
Mus musculus | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Homo sapiens | diacylglycerol + phosphate | - |
? | |
phosphatidic acid + H2O | - |
Rattus norvegicus | diacylglycerol + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Mus musculus | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Homo sapiens | sphingosine + phosphate | - |
? | |
sphingosine 1-phosphate + H2O | - |
Rattus norvegicus | sphingosine + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lipid phosphate phosphatase-2 | - |
Homo sapiens |
LPP1 | - |
Mus musculus |
LPP2 | - |
Homo sapiens |
LPP3 | - |
Rattus norvegicus |