Literature summary for 3.1.3.4 extracted from

Mlinar, B.; Pfeifer, M.; Vrtacnik-Bokal, E.; Jensterle, M.; Marc, J.
Decreased lipin 1 beta expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome (2008), Eur. J. Endocrinol., 159, 833-839.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	visceral adipose tissue	Homo sapiens	-
subcutaneous adipose tissue	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
lipin 1beta	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	in polycystic ovary syndrome patients, lipin 1beta expression in subcutaneous and visceral adipose tissue depots is lower than in controls. In polycystic ovary syndrome patients, visceral adipose lipin 1beta expression correlates negatively with homeostasis model assessment-insulin resistance, body mass index and waist circumference. Subcutaneous lipin 1beta expression in polycystic ovary syndrome patients correlates negatively with body mass index, waist circumference and plasma triglycerides	down
Homo sapiens	expression of lipin 1beta in viscera adipose tissue does not correlate with PPARG, LPL, LIPE, adiponectin and SLC2A4 gene expression	additional information
Homo sapiens	subcutaneous lipin 1beta expression in polycystic ovary syndrome patients correlates positively with high density lipoprotein-cholesterol. Expression of lipin 1beta in subcutaneous adipose tissue correlates positively with PPARG, LPL, LIPE, adiponectin and SLC2A4 gene expression	up

General Information

General Information	Comment	Organism
physiological function	lipin 1beta appears to be involved in the pathogenesis of insulin resistance in polycystic ovary syndrome	Homo sapiens

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Release 2023.1 (January 2023)